KEGG   ENZYME: 1.1.1.38Help
Entry
EC 1.1.1.38                 Enzyme                                 
Name malate dehydrogenase (oxaloacetate-decarboxylating);
'malic' enzyme;
pyruvic-malic carboxylase;
NAD+-specific malic enzyme;
NAD+-malic enzyme;
NAD+-linked malic enzyme
Class Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname (S)-malate:NAD+ oxidoreductase (oxaloacetate-decarboxylating)
Reaction(IUBMB) (S)-malate + NAD+ = pyruvate + CO2 + NADH [RN:R00214]
Reaction(KEGG) R00214;
(other) R00217
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Substrate (S)-malate [CPD:C00149];
NAD+ [CPD:C00003]
Product pyruvate [CPD:C00022];
CO2 [CPD:C00011];
NADH [CPD:C00004]
Comment Also decarboxylates added oxaloacetate.
Pathway PATH: ec00620  Pyruvate metabolism
PATH: ec01061  Biosynthesis of phenylpropanoids
PATH: ec01062  Biosynthesis of terpenoids and steroids
PATH: ec01066  Biosynthesis of alkaloids derived from terpenoid and
               polyketide
Orthology KO: K00027  malate dehydrogenase (oxaloacetate-decarboxylating)
Genes HSA: 4200(ME2)
PTR: 455422(ME2)
MCC: 711129(ME2)
MMU: 107029(Me2)
RNO: 307270(Me2)
CFA: 476198(ME2)
BTA: 507817(ME2)
ECB: 100069637
MDO: 100010878
OAA: 100078022
TGU: 100221226
XLA: 398584(me2)
XTR: 548395(me2)
DRE: 445233(me2)
POP: POPTR_561733
SCE: YKL029C(MAE1)
AGO: AGOS_AGL068W
KLA: KLLA0E18722g
LTH: KLTH0D06732g
PIC: PICST_89732(MAE1)
PPA: PAS_chr3_0181
VPO: Kpol_348p7
LEL: LELG_04771
ZRO: ZYRO0B01914g
CTP: CTRG_02875
CDU: CD36_61770
CGR: CAGL0L02035g
YLI: YALI0E18634g
SPO: SPCC794.12c(mae2)
NCR: NCU02906
PAN: PODANSg09257
MGR: MGG_08562
FGR: FG00805.1
ANI: AN6933.2
AFM: AFUA_7G02420
AOR: AO090038000621
ANG: An12g00160
AFV: AFLA_071570
PCS: Pc21g20250
NFI: NFIA_115160
CIM: CIMG_00874
SSL: SS1G_12079
BFU: BC1G_13155
CNE: CNF03780
CNB: CNBF1040 CNBH2110
LBC: LACBIDRAFT_188199 LACBIDRAFT_240874 LACBIDRAFT_255095
     LACBIDRAFT_297458
MGL: MGL_2702
EHI: EHI_044970
EDI: EDI_245690
TET: TTHERM_00569410
PTM: GSPATT00016144001
TBR: Tb11.02.3120 Tb11.02.3130
TCR: 505183.20 505183.30 508647.270 508647.280
LMA: LmjF24.0770
LIF: LinJ24.0420 LinJ24.0430
LBZ: LbrM24_V2.0780 LbrM24_V2.0790
GLA: GL50803_14285
TVA: TVAG_009460 TVAG_241160 TVAG_412220
ECO: b1479(maeA)
ECJ: JW5238(sfcA)
ECD: ECDH10B_1610(maeA)
EBW: BWG_1300(maeA)
ECE: Z2231(sfcA)
ECS: ECs2083
ECF: ECH74115_2091(sfcA)
ETW: ECSP_1963(sfcA)
ECG: E2348C_1613(maeA)
ECC: c1912(sfcA)
ECI: UTI89_C1697(sfcA)
ECP: ECP_1481
ECV: APECO1_615(sfcA)
ECW: EcE24377A_1661(sfcA)
ECX: EcHS_A1564(sfcA)
ECM: EcSMS35_1695(sfcA)
ECY: ECSE_1568
ECL: EcolC_2178
ECK: EC55989_1611(sfcA)
ECQ: ECED1_1632(sfcA)
ECR: ECIAI1_1483(sfcA)
ECT: ECIAI39_1743(sfcA)
ECZ: ECS88_1573(sfcA)
EUM: ECUMN_1734(sfcA)
ELF: LF82_1254(maeA)
EBL: B21_01449(sfcA)
EBD: ECBD_2160
EBR: ECB_01437(sfcA)
EOH: ECO103_1608(sfcA)
EOI: ECO111_1869(sfcA)
EOJ: ECO26_2077(sfcA)
EFE: EFER_1496(sfcA)
STY: STY1494(sfcA)
STT: t1481(sfcA)
SPT: SPA1302(sfcA)
SEK: SSPA1210
SPQ: SPAB_01733
SEI: SPC_2172(sfcA)
SEC: SC1567(sfcA)
SEH: SeHA_C1743
SEE: SNSL254_A1680
SEW: SeSA_A1682
SEA: SeAg_B1599
SED: SeD_A1777
SEG: SG1561(sfcA)
SET: SEN1489(sfcA)
SES: SARI_01403
STM: STM1566(sfcA)
YPE: YPO1511(sfcA)
YPK: y2658(sfcA)
YPM: YP_1401(sfcA1)
YPA: YPA_0806
YPN: YPN_2468
YPP: YPDSF_1463
YPS: YPTB1526(sfcA)
YPI: YpsIP31758_2463
YPY: YPK_2562
YPB: YPTS_1636
YEN: YE2794(maeA)
SFL: SF1746(sfcA)
SFX: S1879(sfcA)
SFV: SFV_1742(sfcA)
SSN: SSON_1645(sfcA)
SBO: SBO_1578(sfcA)
SBC: SbBS512_E1742(sfcA)
ECA: ECA2831(sfcA)
PCT: PC1_1494
PWA: Pecwa_2971
ETA: ETA_12950(sfcA)
PLU: plu1546(maeA)
PAY: PAU_02896(sfcA)
SGL: SG0967
ENT: Ent638_2047
ESA: ESA_02975
CTU: Ctu_08890(sfcA)
KPN: KPN_01847(sfcA)
KPE: KPK_1916 KPK_2508(sfcA)
KPU: KP1_2910(sfcA)
CKO: CKO_01517
SPE: Spro_1567
PMR: PMI0642(sfcA)
EIC: NT01EI_1281
ETR: ETAE_1161
HDE: HDEF_1806(sfcA)
DDA: Dd703_2451
DDC: Dd586_2497
DZE: Dd1591_2546
AAT: D11S_1980
VCH: VC1188
VCO: VC0395_A0809(sfcA)
VCM: VCM66_1143(sfcA)
VCJ: VCD_003155
VVU: VV1_2801
VVY: VV1464 VV2242
VPA: VP1258
VHA: VIBHAR_02034
VSP: VS_1202
VEX: VEA_003737
VFI: VF_1558(maeA)
VFM: VFMJ11_1654
VSA: VSAL_I1274(sfcA)
PPR: PBPRA1997 PBPRB1354
PAE: PA3471
PAU: PA14_19190(sfcA)
PAP: PSPA7_1656
PAG: PLES_15411
PST: PSPTO_3924(sfcA)
PSB: Psyr_1561
PSP: PSPPH_1545
CJA: CJA_1688(sfcA1)
PAR: Psyc_1387
PCR: Pcryo_0982
ACI: ACIAD0166(sfcA)
ACB: A1S_0140
ABY: ABAYE3731(sfcA)
ABC: ACICU_00164
ABN: AB57_0179
ABB: ABBFA_003379(sfcA)
SON: SO_3855(sfcA)
SDN: Sden_0736
SFR: Sfri_0833
SAZ: Sama_2621
SBL: Sbal_0676
SBM: Shew185_3634
SBN: Sbal195_3757
SBP: Sbal223_3566
SLO: Shew_2962
SPC: Sputcn32_0784
SSE: Ssed_3518
SPL: Spea_3186
SHE: Shewmr4_3188
SHM: Shewmr7_0778
SHN: Shewana3_0750
SHW: Sputw3181_3391
SHL: Shal_3267
SWD: Swoo_0902
SWP: swp_3875
ILO: IL0598(sfcA)
CPS: CPS_4262(sfcA)
PHA: PSHAa1565(sfcA)
PAT: Patl_0724
AMC: MADE_00517
PIN: Ping_0537
CBU: CBU_0823(sfcA)
CBS: COXBURSA331_A1127(sfcA)
CBD: CBUD_0888(sfcA)
CBG: CbuG_1178(sfcA)
CBC: CbuK_0691(sfcA)
LPN: lpg0651 lpg1280(sfcA) lpg2971(maeA)
LPF: lpl1243(sfcA) lpl2901
LPP: lpp1243(sfcA) lpp3043
LPC: LPC_0705(sfcA) LPC_2643(mao2) LPC_3286(maeA)
MCA: MCA1836(sfcA)
FTU: FTT_0917(maeA)
FTF: FTF0917(maeA)
FTW: FTW_1262
FTL: FTL_0438
FTH: FTH_0430(maeA)
FTA: FTA_0460
FTM: FTM_0505(maeA)
FTN: FTN_0443(maeA)
FPH: Fphi_0394
CSA: Csal_2963
AHA: AHA_1243 AHA_1278 AHA_3059
ASA: ASA_1233(sfcA) ASA_1264(maeA)
TAU: Tola_0213
RMA: Rmag_0819
KKO: Kkor_2441
NMA: NMA0870
NME: NMB0671(sfcA)
NMC: NMC0620(maeA)
NGO: NGO0240
NGK: NGK_0374
BPD: BURPS668_0794
HHE: HH1094
CJE: Cj1287c
ABU: Abu_1076(maeA)
GSU: GSU2308(scfA)
DDS: Ddes_1534
BBA: Bd2834(sfcA)
DPS: DP2203
DAT: HRM2_13730(mae)
SCL: sce5603(maeB1)
SAT: SYN_00517
MET: M446_1242
ZMO: ZMO1955
ZMN: Za10_1214
GBE: GbCGDNIH1_2016
BSU: BSU23550(mleA) BSU29220(ytsJ) BSU29880(malS) BSU37050(ywkA)
BHA: BH0399 BH3168
BAN: BA0579 BA1801(ykwA) BA3145 BA4848
BAR: GBAA0579 GBAA1801(ykwA) GBAA3145 GBAA4848
BAA: BA_1159 BA_2306 BA_5271
BAT: BAS0548 BAS1668 BAS2923 BAS4497
BAH: BAMEG_1466 BAMEG_2791(malS) BAMEG_4007 BAMEG_4879
BAI: BAA_0662 BAA_1871(malS) BAA_3192 BAA_4859
BCE: BC0580 BC1741 BC4604
BCA: BCE_0642 BCE_1873(ykwA) BCE_4734
BCZ: BCZK0492(sfcA) BCZK1615
BCR: BCAH187_A1922(malS) BCAH187_A4729
BCB: BCB4264_A0617 BCB4264_A1812(malS) BCB4264_A3134 BCB4264_A4713
BCU: BCAH820_0635 BCAH820_1848(malS) BCAH820_4718
BCG: BCG9842_B0524 BCG9842_B3529(malS) BCG9842_B4722
BCQ: BCQ_0645(sfcA) BCQ_1813(ykwA) BCQ_4407(mdh)
BCX: BCA_0610 BCA_1808(malS) BCA_4713
BCY: Bcer98_0499 Bcer98_3287
BTK: BT9727_0490(sfcA) BT9727_1650
BTL: BALH_0520(sfcA) BALH_1583(ykwA)
BWE: BcerKBAB4_0493 BcerKBAB4_1666 BcerKBAB4_4433
BLI: BL00044(malS) BL00406(ytsJ) BL00922(mleA) BL03976(maeA)
BLD: BLi03071(ytsJ) BLi03139(malS) BLi03953(ywkA) BLi04137(mleA)
BCL: ABC0918 ABC2723
BAY: RBAM_021680(mleA) RBAM_026270(ytsJ) RBAM_026990(malS)
     RBAM_034210(ywkA)
BPU: BPUM_2635(malS) BPUM_3348(ywkA)
OIH: OB2176 OB3218
GKA: GK1440 GK1534
GTN: GTNG_1301 GTNG_1385
GWC: GWCH70_1376 GWCH70_1912
GYM: GYMC10_0780
GYC: GYMC61_2232 GYMC61_2371
AFL: Aflv_0495 Aflv_2045
SAU: SA1524
SAV: SAV1702
SAW: SAHV_1688
SAM: MW1645
SAR: SAR0824 SAR1780
SAS: SAS1629
SAB: SAB0723 SAB1560c
SAJ: SaurJH9_1758
SAH: SaurJH1_1792
SAD: SAAV_1711
SEP: SE1377
SER: SERP1265
SHA: SH1223
SSP: SSP1065
SCA: Sca_1307
LMO: lmo1915
LMF: LMOf2365_1944(sfcA)
LMH: LMHCC_0641
LMC: Lm4b_01932
LIN: lin2029
LWE: lwe1934(malS)
LSP: Bsph_2148
BBE: BBR47_13780(ytsJ)
PJD: Pjdr2_5002
AAC: Aaci_0140 Aaci_2141
LLA: L121483(mleS) L3227(mae)
LLK: LLKF_0928(mleS)
LLM: llmg_1638(mleS)
SPZ: M5005_Spy_0833
SPM: spyM18_1072
SPA: M6_Spy0831
SPB: M28_Spy0810
SOZ: Spy49_0864
SAG: SAG1919
SAN: gbs1906
SAK: SAK_1878
SMU: SMU.137(mleS)
SSA: SSA_0297(mleS)
SGO: SGO_0372
SUB: SUB0825
SDS: SDEG_0873
LPL: lp_1105(mae) lp_1118(mleS)
LPJ: JDM1_0911(mae) JDM1_0922(mleS)
LAC: LBA1075
LSA: LSA0441(mleS)
LSL: LSL_1313
LBR: LVIS_2203
LCA: LSEI_0740
LCB: LCABL_08060(mleS) LCABL_30690(mae)
LRE: Lreu_1532
LRF: LAR_1441
LRH: LGG_00726(mleS) LGG_02875
LRL: LC705_00719(mleS) LC705_02859(mae)
PPE: PEPE_1617
EFA: EF3316
OOE: OEOE_0418 OEOE_1564
LME: LEUM_1005
LCI: LCK_00106 LCK_00751(mleS)
CAC: CAC1589(malS) CAC1596(malS)
CPE: CPE1151
CPR: CPR_0140
CTC: CTC00356 CTC02463
CNO: NT01CX_2051
CTH: Cthe_0344
CDF: CD1005
CDC: CD196_0878
CDL: CDR20291_0858
CBO: CBO0210 CBO0246
CBA: CLB_0251 CLB_0289
CBH: CLC_0266 CLC_0304
CBY: CLM_0260
CBL: CLK_3389
CBK: CLL_A3577
CBB: CLD_0518 CLD_0565
CBI: CLJ_B0258
CBT: CLH_3371
CBF: CLI_0275 CLI_0318
CBE: Cbei_4008 Cbei_5075
CKR: CKR_2124
CPY: Cphy_0409
CCE: Ccel_0138
AMT: Amet_1304 Amet_2965 Amet_3229
STH: STH1319 STH2534
VPR: Vpar_0439
ATE: Athe_1062
DSY: DSY1923
DHD: Dhaf_0902 Dhaf_3085
DRM: Dred_2955
PTH: PTH_2899(sfcA)
FMA: FMG_0499
APR: Apre_0229
EEL: EUBELI_01448
ERE: EUBREC_1483
TTE: TTE2332(sfcA)
TEX: Teth514_0830
TPD: Teth39_0337
MTA: Moth_0401
ADG: Adeg_0169
CSC: Csac_2059
CPO: COPRO5265_0583
NTH: Nther_2399
HOR: Hore_10070
POY: PAM721(sfcA)
AYW: AYWB_051(sfcA)
PML: ATP_00450(sfcA)
PAL: PAa_0769(sfcA)
MTU: Rv2332(mez)
MTC: MT2394(sfcA)
MRA: MRA_2352(mez)
MTF: TBFG_12356
MTB: TBMG_01646(TBMG_01646.1)
MBO: Mb2360(mez)
MBB: BCG_2354(mez)
MBT: JTY_2348(mez)
MPA: MAP2540c
MAV: MAV_1381
MSM: MSMEG_5055
MUL: MUL_1467(mez) MUL_4503(mez_1)
MVA: Mvan_4481
MGI: Mflv_2214
MAB: MAB_1384
MMC: Mmcs_3977
MKM: Mkms_4051
MJL: Mjls_3991
MMI: MMAR_3643(mez) MMAR_4197(mez_1)
CGT: cgR_2895
CEF: CE2839(malE)
CKP: ckrop_0541(mez)
NFA: nfa47090
RHA: RHA1_ro00492 RHA1_ro02571 RHA1_ro06000 RHA1_ro08928
     RHA1_ro11316
RER: RER_41320
ROP: ROP_22960 ROP_33750 ROP_60600
GBR: Gbro_0588
SCO: SCO2951(SCE59.10c) SCO5261(2SC7G11.23)
SMA: SAV_1514(malS1) SAV_2981 SAV_3870(malS2) SAV_5126
SGR: SGR_2236 SGR_4581
ART: Arth_3432 Arth_3994
AAU: AAur_3406 AAur_3836
ACH: Achl_3211 Achl_3773
RSA: RSal33209_2445
BCV: Bcav_3529
BFA: Bfae_08210 Bfae_20210
KSE: Ksed_00620 Ksed_10480
PAC: PPA0313 PPA0888
NCA: Noca_0113 Noca_1727 Noca_2034
TFU: Tfu_0562 Tfu_2390
TCU: Tcur_3684 Tcur_3884
SRO: Sros_1706 Sros_8298
FRA: Francci3_3751
FRE: Franean1_0980
FAL: FRAAL5985
ACE: Acel_1647
NML: Namu_0264 Namu_1419 Namu_4139
SEN: SACE_0563 SACE_6415
SVI: Svir_30630 Svir_34210
AMI: Amir_0465 Amir_6279
STP: Strop_1448 Strop_3695
SAQ: Sare_1406 Sare_4075
CAI: Caci_1467 Caci_4404 Caci_7700
RXY: Rxyl_1110
AFO: Afer_0622 Afer_1947
SHI: Shel_05030
APV: Apar_1191
TDE: TDE2446
ACA: ACP_2736
SUS: Acid_2954
SRU: SRU_1786
AAS: Aasi_0353
LBA: Lebu_1156
STR: Sterm_1956
RBA: RB307
EMI: Emin_0296
RSD: TGRD_287
TAI: Taci_0215
SYN: slr0721(me)
SYC: syc0256_c
SYF: Synpcc7942_1297
SYP: SYNPCC7002_A0448
CYA: CYA_0662
CYB: CYB_0613
TEL: tll1440
MAR: MAE_07860
CYT: cce_3246
CYP: PCC8801_2893
CYC: PCC7424_1195
CYN: Cyan7425_0554
CYH: Cyan8802_3203
GVI: gll2149
ANA: alr4596
NPU: Npun_F1023
AVA: Ava_2458
TER: Tery_3983
AMR: AM1_3904
CPH: Cpha266_1271
CLI: Clim_1316
PLT: Plut_0896
PPH: Ppha_1089
CTS: Ctha_2660
RRS: RoseRS_2286 RoseRS_3704
RCA: Rcas_2490 Rcas_3529
CAU: Caur_1614
CAG: Cagg_3355
CHL: Chy400_1751
DRA: DR_2583 DR_A0276
DGE: Dgeo_2154
DDR: Deide_20160
TTH: TTC0144
TTJ: TTHA0520
TMA: TM0542
TPT: Tpet_0379
TLE: Tlet_0836
TRQ: TRQ2_0395
TNA: CTN_0126
TNP: Tnap_0322
FNO: Fnod_0471
PMO: Pmob_0949
KOL: Kole_0487
DTH: DICTH_0823
DTU: Dtur_0967
TYE: THEYE_A0769
MAC: MA1735
MBA: Mbar_A3045
MMA: MM_2632
MTP: Mthe_0409
MHU: Mhun_0147
MPL: Mpal_0242
AFU: AF1727(mae)
TAC: Ta0456m
TVO: TVN0768
PTO: PTO0957
PAB: PAB1792(mae)
PFU: PF1026
TKO: TK1963
TGA: TGAM_0399(maeB)
TSI: TSIB_0123
APE: APE_0392
HBU: Hbut_0153
SSO: SSO2869
STO: ST0114 ST0278
SAI: Saci_2154
SIS: LS215_2611
SIA: M1425_2439
SIM: M1627_2515
SID: M164_2444
SIY: YG5714_2590
SIN: YN1551_0317
PAI: PAE1688
PIS: Pisl_1691
PCL: Pcal_0564
PAS: Pars_2233
CMA: Cmaq_0373
KCR: Kcr_0950
Taxonomy
Structures PDB: 1GZ3  1LLQ  1O0S  1PJL  1WW8  2DVM  
Reference
  Authors
  Title

  Journal
  Organism
 1  [PMID:14917678]
KAUFMAN S, KORKES S, DEL CAMPILLO A.
Biosynthesis of dicarboxylic acids by carbon dioxide fixation. V.
Further study of the "malic" enzyme of Lactobacillus arabinosus.
J. Biol. Chem. 192 (1951) 301-12.
Lactobacillus arabinosus
Other DBs ExplorEnz - The Enzyme Database: 1.1.1.38
IUBMB Enzyme Nomenclature: 1.1.1.38
ExPASy - ENZYME nomenclature database: 1.1.1.38
BRENDA, the Enzyme Database: 1.1.1.38
CAS: 9080-52-8
DBGET integrated database retrieval system