KEGG   ENZYME: 1.1.1.43Help
Entry
EC 1.1.1.43                 Enzyme                                 

Name
phosphogluconate 2-dehydrogenase;
6-phosphogluconic dehydrogenase;
phosphogluconate dehydrogenase;
gluconate 6-phosphate dehydrogenase;
6-phosphogluconate dehydrogenase (NAD+);
2-keto-6-phosphogluconate reductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
6-phospho-D-gluconate:NAD(P)+ 2-oxidoreductase
Reaction(IUBMB)
6-phospho-D-gluconate + NAD(P)+ = 6-phospho-2-dehydro-D-gluconate + NAD(P)H + H+ [RN:R02032 R02034]
Reaction(KEGG)
Substrate
6-phospho-D-gluconate [CPD:C00345];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
6-phospho-2-dehydro-D-gluconate [CPD:C01218];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
History
EC 1.1.1.43 created 1961
Pathway
Pentose phosphate pathway
Glutathione metabolism
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K00032  
phosphogluconate 2-dehydrogenase
Genes
PAE: 
PAEV: 
PAEI: 
PAU: 
PAP: 
PAG: 
PAF: 
PNC: 
PDK: 
PSG: 
PRP: 
PAEP: 
PAER: 
PAEM: 
PAEL: 
PAES: 
PAEU: 
PAEG: 
PAEC: 
PAEO: 
PPU: 
PP_3376(kguD)
PPF: 
PPG: 
PPW: 
PPT: 
PPB: 
PPI: 
PPX: 
T1E_5148(tkrA)
PPUH: 
PPUT: 
PPUN: 
PP4_27660(kguD)
PPUD: 
PMOS: 
PPUU: 
PFL: 
PFL_2717(ghrB1)
PPRC: 
PFO: 
PFS: 
PFE: 
PFC: 
PFN: 
PPZ: 
PSTT: 
PBA: 
PBC: 
PSK: 
PMON: 
PMOT: 
PCH: 
PCP: 
AVN: 
AVL: 
AVD: 
CSA: 
HCS: 
REH: 
H16_B1813(kguD)
 » show all
Taxonomy
Reference
1  [PMID:13894458]
  Authors
FRAMPTON EW, WOOD WA.
  Title
Carbohydrate oxidation by Pseudomonas fluorescens VI. Conversion of 2-keto-6-phosphogluconate to pyruvate.
  Journal
J. Biol. Chem. 236 (1961) 2571-7.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9001-82-5

DBGET integrated database retrieval system