KEGG   ENZYME: 1.1.1.43Help
Entry
EC 1.1.1.43                 Enzyme                                 
Name
phosphogluconate 2-dehydrogenase;
6-phosphogluconic dehydrogenase;
phosphogluconate dehydrogenase;
gluconate 6-phosphate dehydrogenase;
6-phosphogluconate dehydrogenase (NAD+);
2-keto-6-phosphogluconate reductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
6-phospho-D-gluconate:NAD(P)+ 2-oxidoreductase
Reaction(IUBMB)
6-phospho-D-gluconate + NAD(P)+ = 6-phospho-2-dehydro-D-gluconate + NAD(P)H + H+ [RN:R02032 R02034]
Reaction(KEGG)
Substrate
6-phospho-D-gluconate [CPD:C00345];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
6-phospho-2-dehydro-D-gluconate [CPD:C01218];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Pathway
Pentose phosphate pathway
Glutathione metabolism
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K00032  
phosphogluconate 2-dehydrogenase
Genes
PAE: 
PAU: 
PAP: 
PAG: 
PAF: 
PNC: 
PDK: 
PPU: 
PP_3376(kguD)
PPF: 
PPG: 
PPW: 
PputW619_2571
PPT: 
PPS_2854
PPB: 
PPUBIRD1_2404
PPI: 
YSA_11138
PPX: 
T1E_5148(tkrA)
PFL: 
PFL_2717(ghrB1)
PFO: 
Pfl01_2904
PFS: 
PFLU2712
PFE: 
PSF113_3674(kguD)
PFC: 
PflA506_2981(ghrB1)
PBA: 
PSEBR_a3251
AVN: 
Avin_26910(kguD)
REH: 
H16_B1813(kguD)
 » show all
Taxonomy
Reference
1  [PMID:13894458]
  Authors
FRAMPTON EW, WOOD WA.
  Title
Carbohydrate oxidation by Pseudomonas fluorescens VI. Conversion of 2-keto-6-phosphogluconate to pyruvate.
  Journal
J. Biol. Chem. 236 (1961) 2571-7.
  Organism
Pseudomonas fluorescens
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9001-82-5
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