KEGG   ENZYME: 1.1.1.45Help
Entry
EC 1.1.1.45                 Enzyme                                 
Name L-gulonate 3-dehydrogenase;
L-3-aldonate dehydrogenase;
L-3-aldonic dehydrogenase;
L-gulonic acid dehydrogenase;
L-beta-hydroxyacid dehydrogenase;
L-beta-hydroxy-acid-NAD+-oxidoreductase;
L-3-hydroxyacid dehydrogenase
Class Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname L-gulonate:NAD+ 3-oxidoreductase
Reaction(IUBMB) L-gulonate + NAD+ = 3-dehydro-L-gulonate + NADH + H+ [RN:R02640]
Reaction(KEGG) R02640
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Substrate L-gulonate [CPD:C00800];
NAD+ [CPD:C00003]
Product 3-dehydro-L-gulonate [CPD:C00618];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment Also oxidizes other L-3-hydroxyacids.
Pathway PATH: ec00040  Pentose and glucuronate interconversions
PATH: ec01100  Metabolic pathways
Orthology KO: K13247  L-gulonate 3-dehydrogenase
Genes HSA: 51084(CRYL1)
PTR: 452458(CRYL1)
MCC: 703988(CRYL1)
MMU: 68631(Cryl1)
RNO: 290277(Cryl1)
CFA: 486050(CRYL1)
BTA: 281725(CRYL1)
SSC: 396914(CRY)
ECB: 100054141
OAA: 100089465
GGA: 418953(CRYL1)
TGU: 100232047
XLA: 100036971
XTR: 100145620
DRE: 751596(cryl1)
BFO: BRAFLDRAFT_116612
CIN: 100176260
SPU: 589657
DME: Dmel_CG10131 Dmel_CG9914
DPO: Dpse_GA10097 Dpse_GA23040
DAN: Dana_GF11336 Dana_GF19071
DER: Dere_GG19334 Dere_GG20470
DPE: Dper_GL11451 Dper_GL21343
DSE: Dsec_GM13412 Dsec_GM21560
DSI: Dsim_GD11066
DYA: Dyak_GE11007 Dyak_GE13601
DGR: Dgri_GH12278 Dgri_GH22921
DMO: Dmoj_GI10976 Dmoj_GI18410
AAG: AaeL_AAEL008006
CQU: CpipJ_CPIJ019115
AME: 406119(Cryl1)
NVI: 100116345
TCA: 656318
API: 100160442
ISC: IscW_ISCW024631
CEL: Y71F9B.9
CBR: CBG04121
NVE: NEMVE_v1g168735
HMG: 100202070
MBR: MONBRDRAFT_2035
Taxonomy
Structures PDB: 2DPO  3A97  
Reference
  Authors
  Title
  Journal
 1
Dworsky, P. and Hoffmann-Ostenhof, O.
L-3-Aldonic acid dehydrogenase from Schwanniomyces occidentalis.
Acta Biochim. Pol. 11 (1964) 269-277.
Reference
  Authors
  Title


  Journal
 2
Smiley, J.D. and Ashwell, G.
Purification and properties of beta-L-hydroxy acid dehydrogenase.
II. Isolation of beta-keto-L-gluconic acid, an intermediate in
L-xylulose biosynthesis.
J. Biol. Chem. 236 (1961) 357-364.
Other DBs ExplorEnz - The Enzyme Database: 1.1.1.45
IUBMB Enzyme Nomenclature: 1.1.1.45
ExPASy - ENZYME nomenclature database: 1.1.1.45
BRENDA, the Enzyme Database: 1.1.1.45
CAS: 9028-51-7
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