| Entry |
|
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| Name |
glucose 1-dehydrogenase;
D-glucose dehydrogenase (NAD(P)+);
hexose phosphate dehydrogenase |
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| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
 |
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| Sysname |
beta-D-glucose:NAD(P)+ 1-oxidoreductase |
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| Reaction(IUBMB) |
beta-D-glucose + NAD(P)+ = D-glucono-1,5-lactone + NAD(P)H + H+
[RN:R01520 R01521] |
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| Reaction(KEGG) |
R01520 R01521
 |
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| Substrate |
beta-D-glucose [CPD:C00221];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006] |
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| Product |
D-glucono-1,5-lactone [CPD:C00198];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080] |
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| Comment |
Also oxidizes D-xylose. |
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| Pathway |
PATH: ec00030 Pentose phosphate pathway |
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| Orthology |
KO: K00034 glucose 1-dehydrogenase |
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| Genes |
HSA: 9563(H6PD)
MCC: 710107
MMU: 100198(H6pd)
RNO: 298655(H6pd)
CFA: 489642(H6PD)
BTA: 541220(H6PD)
ECB: 100057646
MDO: 100009940
GGA: 428188(H6PD)
TGU: 100228049
DRE: 569348
NVE: NEMVE_v1g31531
ETA: ETA_30410(gdh)
PMR: PMI1532
PAE: PA3128
PAU: PA14_23650(ygfF)
PAP: PSPA7_2004
PST: PSPTO_2492
PSB: Psyr_2297
PSP: PSPPH_2879
PFL: PFL_4100
PFO: Pfl01_1840
PMY: Pmen_0069
AHA: AHA_1994
AFE: Lferr_1879
AFR: AFE_1857 AFE_2225
RSO: RSc2504
RPI: Rpic_2772
REU: Reut_B5464
BMA: BMA1859
BMV: BMASAVP1_A1103
BML: BMA10229_A0763
BMN: BMA10247_0386
BPS: BPSL1186
BPM: BURPS1710b_1408
BPL: BURPS1106A_1270
BPD: BURPS668_1263
BTE: BTH_I1035
BVI: Bcep1808_2360
BUR: Bcep18194_A5602
BCN: Bcen_1663
BCH: Bcen2424_2275
BCM: Bcenmc03_2298
BCJ: BCAL2369
BAM: Bamb_2313
BAC: BamMC406_2191
BMU: Bmul_1003
BMJ: BMULJ_02261(gdh)
BXE: Bxe_A3241 Bxe_B0443
BPH: Bphy_2032
BPY: Bphyt_1318
POL: Bpro_0239
AAV: Aave_0320
AJS: Ajs_0259 Ajs_3234
MPT: Mpe_A3527
MMS: mma_0691
TBD: Tbd_0924
MES: Meso_1253
BME: BMEI0861
BMS: BR1122
OAN: Oant_2512
BJA: bll7157 bll7185(gdh)
BRA: BRADO1396
BBT: BBta_6708
AZC: AZC_4194
MRD: Mrad2831_0925
RDE: RD1_3328
GOX: GOX2015
ACR: Acry_2603 Acry_3136
GDI: GDI_2625(gdh)
GDJ: Gdia_0840
BSU: BSU02830(ycdF) BSU03930(gdh)
BAN: BA4968(gdh)
BAR: GBAA4968(gdh)
BAA: BA_5386
BAT: BAS4612
BAH: BAMEG_4999(gdh)
BAI: BAA_4978(gdh)
BCE: BC3460 BC4715
BCA: BCE_4858(gdh)
BCZ: BCZK4466(gdh) pE33L466_0368(gdh)
BCR: BCAH187_A4852(gdh)
BCB: BCB4264_A4828(gdh)
BCU: BCAH820_4834(gdh)
BCG: BCG9842_B0408(gdh)
BCQ: BCQ_4529(gdh)
BCX: BCA_4839(gdh)
BCY: Bcer98_3132
BTK: BT9727_4448(gdh)
BTL: BALH_3120 BALH_4289(gdh)
BWE: BcerKBAB4_4547
BLI: BL01382(gdh) BL01687(ycdF)
BLD: BLi00341(ycdF) BLi02566(gdh)
BAY: RBAM_004180(gdh)
BPU: BPUM_2122(gdh)
OIH: OB3183
SAA: SAUSA300_2416
SEP: SE1830
SER: SERP1839(gdh)
SHA: SH0795
SSP: SSP0656
SCA: Sca_1743(gdh)
ESI: Exig_0211
MCL: MCCL_0186
LAC: LBA1098
LSL: LSL_0144(gdh)
LCA: LSEI_2180
LCB: LCABL_23550(gdh)
LRH: LGG_02189(gdh)
LRL: LC705_02185(gdh)
PPE: PEPE_0073
EFA: EF2382(gdh)
SCO: SCO1335(2SCG61.17c)
SMA: SAV_1922(gdh)
FRA: Francci3_2849
STP: Strop_0661
SUS: Acid_7577
CHU: CHU_1661(gdh)
RBA: RB10002(gcd) RB7294(gdh)
SYN: sll1709(gdh)
SYG: sync_1918
SYR: SynRCC307_1928(gdh)
SYX: SynWH7803_0725(gdh)
CYT: cce_0222
GVI: gll1114 gll1167
ANA: all3836
AVA: Ava_1863
HMA: rrnAC0011(ywfD1) rrnAC2741(ywfD2)
HWA: HQ1663A(gdh)
TAC: Ta0897
TVO: TVN1019
PTO: PTO0639 PTO1070
PHO: PH1809
PFU: PF1853
TKO: TK0673
RCI: RCIX1128(dhg)
HBU: Hbut_1375
SSO: SSO3003(dhg-1) SSO3042(dhg-2) SSO3204(dhg-3)
STO: ST1704
SAI: Saci_1079
MSE: Msed_1301
 |
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| Structures |
PDB: 1G6K 1GCO 1GEE 1RWB 1SPX 2B5V 2B5W 2CD9 2CDA 2CDB
2CDC 2VWG 2VWH 2VWP 2VWQ |
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Reference
Authors
Title
Journal
Organism
|
1 [PMID:810982]
Banauch D, Brummer W, Ebeling W, Metz H, Rindfrey H, Lang H, Leybold
K, Rick W, Staudinger HJ.
[A glucose dehydrogenase for the determination of glucose
concentrations in body fluids (author's transl)]
Z. Klin. Chem. Klin. Biochem. 13 (1975) 101-7.
Bacillus megaterium |
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Reference
Authors
Title
Journal
|
2
Brink, N.G.
Beef liver glucose dehydrogenase. 1. Purification and properties.
Acta Chem. Scand. 7 (1953) 1081-1089. |
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Reference
Authors
Title
Journal
|
3
Pauly, H.E. and Pfleiderer, G.
D-Glucose dehydrogenase from Bacillus megaterium M 1286:
purification, properties and structure.
Hoppe-Seyler's Z. Physiol. Chem. 356 (1976) 1613-1623. |
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Reference
Authors
Title
Journal
Organism
|
4 [PMID:12981017]
STRECKER HJ, KORKES S.
Glucose dehydrogenase.
J. Biol. Chem. 196 (1952) 769-84.
Bos taurus [GN:bta] |
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Reference
Authors
Title
Journal
Organism
|
5 [PMID:4392298]
Thompson RE, Carper WR.
Glucose dehydrogenase from pig liver. I. Isolation and purification.
Biochim. Biophys. Acta. 198 (1970) 397-406.
Sus scofa [GN:ssc] |
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| Other DBs |
ExplorEnz - The Enzyme Database: 1.1.1.47
IUBMB Enzyme Nomenclature: 1.1.1.47
ExPASy - ENZYME nomenclature database: 1.1.1.47
BRENDA, the Enzyme Database: 1.1.1.47
CAS: 9028-53-9 |
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