| Entry |
|
|---|
| Name |
3alpha-hydroxysteroid dehydrogenase (B-specific);
hydroxyprostaglandin dehydrogenase;
3alpha-hydroxysteroid oxidoreductase;
sterognost 3alpha |
|---|
| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
3alpha-hydroxysteroid:NAD(P)+ oxidoreductase (B-specific) |
|---|
| Reaction(IUBMB) |
androsterone + NAD(P)+ = 5alpha-androstane-3,17-dione + NAD(P)H + H+
[RN:R02476 R02477] |
|---|
| Reaction(KEGG) |
R02476 R02477;
(other) R04309 R04310 R04818 R04819 R04824 R04825 R04829 R04830
R04832 R04833 R04835 R04836 R04837 R04838 R04842 R04843 R04845
R04846 R08963
 |
|---|
| Substrate |
androsterone [CPD:C00523];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006] |
|---|
| Product |
5alpha-androstane-3,17-dione [CPD:C00674];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080] |
|---|
| Comment |
Also acts on other 3alpha-hydroxysteroids and on 9-, 11- and
15-hydroxyprostaglandin. B-specific with respect to NAD+ or NADP+. |
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| Pathway |
PATH: ec00120 Primary bile acid biosynthesis
PATH: ec00140 Steroid hormone biosynthesis
PATH: ec01100 Metabolic pathways |
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| Orthology |
KO: K00037 3-alpha-hydroxysteroid dehydrogenase |
|---|
| Genes |
HSA: 1109(AKR1C4)
XFA: XF2269
XFT: PD1305
XCC: XCC0353(drb0080)
XCB: XC_0365
XCA: xccb100_0379
XCV: XCV0366
XAC: XAC0353(drb0080)
PSB: Psyr_2733
PSP: PSPPH_2428
PHA: PSHAa2145(hsdA)
RSO: RS05193(RSp0230)
REH: H16_B0673
POL: Bpro_0129
MLO: mll7199
RLE: pRL120488
SAL: Sala_0895
MPA: MAP0698
MAV: MAV_5096
MSM: MSMEG_4862
MVA: Mvan_2008 Mvan_4241
MGI: Mflv_2405 Mflv_4338
MMC: Mmcs_3782
MKM: Mkms_3855
MJL: Mjls_3786
ART: Arth_1724
 |
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| Structures |
PDB: 1AFS 1FJH 1FK8 1LWI 1RAL 2DKN 2FVL |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:14406805]
JARABAK J, TALALAY P.
Stereospecificity of hydrogen transfer by pyridine nucleotide-linked
hydroxysteroid dehydrogenases.
J. Biol. Chem. 235 (1960) 2147-51.
Pseudomonas testosteroni |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:13405910]
KOCHAKIAN CD, CARROLL BR, UHRI B.
Comparisons of the oxidation of C19-hydroxysteroids by guinea pig
liver homogenates.
J. Biol. Chem. 224 (1957) 811-8.
Cavia porcellus |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:13295221]
MARCUS PI, TALALAY P.
Induction and purification of alpha- and beta-hydroxysteroid
dehydrogenases.
J. Biol. Chem. 218 (1956) 661-74.
Pseudomonas testosteroni |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:3479982]
Penning TM, Sharp RB.
Prostaglandin dehydrogenase activity of purified rat liver 3
alpha-hydroxysteroid dehydrogenase.
Biochem. Biophys. Res. Commun. 148 (1987) 646-52.
Rattus norvegicus [GN:rno] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.1.1.50
IUBMB Enzyme Nomenclature: 1.1.1.50
ExPASy - ENZYME nomenclature database: 1.1.1.50
BRENDA, the Enzyme Database: 1.1.1.50
CAS: 9028-56-2 |
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