KEGG ENZYME: 1.1.1.50

ENZYME: 1.1.1.50

Entry

EC 1.1.1.50 Enzyme

Name

3alpha-hydroxysteroid 3-dehydrogenase (B-specific);
hydroxyprostaglandin dehydrogenase;
3alpha-hydroxysteroid oxidoreductase;
sterognost 3alpha;
3alpha-hydroxysteroid dehydrogenase (B-specific)

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

3alpha-hydroxysteroid:NAD(P)+ 3-oxidoreductase (B-specific)

Reaction(IUBMB)

a 3alpha-hydroxysteroid + NAD(P)+ = a 3-oxosteroid + NAD(P)H + H+ [RN:R02476 R02477]

Reaction(KEGG)

R02476 R02477;
(other) R04309 R04310 R04818 R04819 R04824 R04825 R04829 R04830 R04832 R04833 R04835 R04836 R04837 R04838 R04842 R04843 R04845 R04846 R08963

Substrate

3alpha-hydroxysteroid [CPD:C03072];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]

Product

3-oxosteroid [CPD:C01876];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

The enzyme acts on androsterone and other 3alpha-hydroxysteroids and on 9-, 11- and 15-hydroxyprostaglandin. B-specific with respect to NAD+ or NADP+. cf. EC 1.1.1.213, 3alpha-hydroxysteroid 3-dehydrogenase (A-specific).

Pathway

ec00120	Primary bile acid biosynthesis
ec00140	Steroid hormone biosynthesis
ec01100	Metabolic pathways

Orthology

K00037

3-alpha-hydroxysteroid dehydrogenase

Genes

HSA:	1109(AKR1C4)
PTR:	450274(AKR1C4)

Reference

1 [PMID:14406805]

Authors

JARABAK J, TALALAY P.

Title

Stereospecificity of hydrogen transfer by pyridine nucleotide-linked hydroxysteroid dehydrogenases.

Journal

J. Biol. Chem. 235 (1960) 2147-51.

Organism

Pseudomonas testosteroni

Reference

2 [PMID:13405910]

Authors

KOCHAKIAN CD, CARROLL BR, UHRI B.

Title

Comparisons of the oxidation of C19-hydroxysteroids by guinea pig liver homogenates.

Journal

J. Biol. Chem. 224 (1957) 811-8.

Organism

Cavia porcellus

Reference

3 [PMID:13295221]

Authors

MARCUS PI, TALALAY P.

Title

Induction and purification of alpha- and beta-hydroxysteroid dehydrogenases.

Journal

J. Biol. Chem. 218 (1956) 661-74.

Organism

Pseudomonas testosteroni

Reference

4 [PMID:3479982]

Authors

Penning TM, Sharp RB.

Title

Prostaglandin dehydrogenase activity of purified rat liver 3 alpha-hydroxysteroid dehydrogenase.

Journal

Biochem. Biophys. Res. Commun. 148 (1987) 646-52.

Organism

Rattus norvegicus [GN:rno]

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.50

IUBMB Enzyme Nomenclature:

1.1.1.50

ExPASy - ENZYME nomenclature database:

1.1.1.50

BRENDA, the Enzyme Database:

1.1.1.50

CAS:

9028-56-2

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (11)   
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Chemical substance (29)   
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Genome (1)   
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Gene (3)   
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Protein sequence (198)   
   UniProt (67)   
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DNA sequence (144)   
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