KEGG   ENZYME: 1.1.1.60Help
Entry
EC 1.1.1.60                 Enzyme                                 
Name 2-hydroxy-3-oxopropionate reductase;
tartronate semialdehyde reductase
Class Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname (R)-glycerate:NAD(P)+ oxidoreductase
Reaction(IUBMB) (R)-glycerate + NAD(P)+ = 2-hydroxy-3-oxopropanoate + NAD(P)H + H+
[RN:R01745 R01747]
Reaction(KEGG) R01745 R01747
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Substrate (R)-glycerate [CPD:C00258];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product 2-hydroxy-3-oxopropanoate [CPD:C01146];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Pathway PATH: ec00630  Glyoxylate and dicarboxylate metabolism
PATH: ec01100  Metabolic pathways
Orthology KO: K00042  2-hydroxy-3-oxopropionate reductase
Genes TCR: 505807.180 507017.40
LMA: LmjF30.0180
ECO: b0509(glxR) b3125(garR)
ECJ: JW0497(glxR) JW5526(garR)
ECD: ECDH10B_0465(glxR) ECDH10B_3298(garR)
EBW: BWG_0386(glxR) BWG_2831(garR)
ECE: Z0663(ybbQ) Z4477(garR)
ECS: ECs0570 ECs4003(garR)
ECF: ECH74115_0610 ECH74115_4437(garR)
ETW: ECSP_0584(glxR) ECSP_4096(garR)
ECG: E2348C_0443(glxR) E2348C_3411(garR)
ECC: c0624(ybbQ) c3880(garR)
ECI: UTI89_C0538(ybbQ) UTI89_C3556(garR)
ECP: ECP_0570 ECP_3215(garR)
ECV: APECO1_1505(ybbQ) APECO1_3302(garR)
ECW: EcE24377A_0546 EcE24377A_3603(garR)
ECX: EcHS_A0583 EcHS_A3314(garR)
ECM: EcSMS35_0552 EcSMS35_3420(garR) EcSMS35_4864(gcxR)
ECY: ECSE_0535 ECSE_3409(garR)
ECL: EcolC_0575(garR) EcolC_3113
ECK: EC55989_0524(glxR) EC55989_3543(garR)
ECQ: ECED1_0529(glxR) ECED1_3786(garR)
ECR: ECIAI1_0512(glxR) ECIAI1_3273(garR)
ECT: ECIAI39_3624(garR)
ECZ: ECS88_0508(glxR) ECS88_3513(garR)
EUM: ECUMN_0550(glxR) ECUMN_3607(garR)
ELF: LF82_0807(garR) LF82_0890(glxR)
EBL: B21_00464(glxR) B21_02941(garR)
EBD: ECBD_0617 ECBD_3148
EBR: ECB_00459(glxR) ECB_02990(garR)
EFE: EFER_4367(garR)
STY: STY0567(garR) STY3430(garR)
STT: t2341(garR) t3168(garR)
SPT: SPA2203 SPA3117(garR)
SEK: SSPA2047 SSPA2910(garR)
SPQ: SPAB_03044 SPAB_04054(garR)
SEI: SPC_0534(garR) SPC_3324(garR)
SEC: SC0559(glxR) SC3195(garR)
SEH: SeHA_C0627 SeHA_C3546(garR)
SEE: SNSL254_A0573 SNSL254_A3510(garR)
SEW: SeSA_A3441(garR)
SEA: SeAg_B0566 SeAg_B3438(garR)
SED: SeD_A0568 SeD_A3607(garR)
SEG: SG0531(glxR) SG3144(garR)
SET: SEN0500(glxR) SEN3088(garR)
SES: SARI_04369(garR)
STM: STM0519(glxR) STM3248(garR)
YPE: YPO3648
YPA: YPA_3661
YPN: YPN_3523
YPS: YPTB3582
SFL: SF3162(garR)
SFX: S3377(garR)
SFV: SFV_3165(garR)
SSN: SSON_3280(garR)
SBO: SBO_2990(garR)
SBC: SbBS512_E3233(garR)
SDY: SDY_3319(garR)
ECA: ECA0489 ECA3573(garR)
PCT: PC1_3393
SGL: SG0507
ENT: Ent638_3567(garR)
KPN: KPN_03537(garR)
KPE: KPK_0573(garR)
KPU: KP1_1363(glxR) KP1_4839(garR)
CKO: CKO_04522(garR)
DDA: Dd703_0845
DZE: Dd1591_0811
MSU: MS0692(garR)
ASU: Asuc_0552 Asuc_1858(garR)
VSP: VS_1248
PPR: PBPRA2273
PAE: PA1500
PAU: PA14_45020(glxR)
PAP: PSPA7_3831
PAG: PLES_39121
PPU: PP_4299(glxR)
PPF: Pput_1570
PPG: PputGB1_3864
PPW: PputW619_2310 PputW619_3624
PFL: PFL_1699
PFO: Pfl01_1596
PEN: PSEEN1670(glxR)
PMY: Pmen_2771
PSA: PST_3116(glxR)
ACB: A1S_1790
ABY: ABAYE1786
ABC: ACICU_01881
ABN: AB57_2118
ABB: ABBFA_001671
SON: SO_2771(garR)
SDN: Sden_2289
SFR: Sfri_1503
SAZ: Sama_1975
PHA: PSHAa1254
MAQ: Maqu_3742
PIN: Ping_2750(garR) Ping_3356
TGR: Tgr7_2984
HCH: HCH_00576
ABO: ABO_1232(yhaE)
RSO: RSc3283(glxR)
RPI: Rpic_2693 Rpic_3480 Rpic_4497
RPF: Rpic12D_3153
REU: Reut_A1500 Reut_A2701 Reut_A3293
REH: H16_A3600
RME: Rmet_1632 Rmet_3450
CTI: RALTA_A2478(garR) RALTA_A3054(glxR) RALTA_B0765(glxR)
BMA: BMAA0577(garR)
BML: BMA10229_0890(garR)
BMN: BMA10247_A1857(garR)
BPS: BPSL1450(glxR)
BPM: BURPS1710b_2426
BPL: BURPS1106A_2301 BURPS1106A_A1920(garR)
BPD: BURPS668_2261
BTE: BTH_I2171 BTH_II0977
BVI: Bcep1808_1804 Bcep1808_1879
BUR: Bcep18194_A5180 Bcep18194_A5264
BCN: Bcen_6125 Bcen_6199
BCH: Bcen2424_1880 Bcen2424_1953
BCM: Bcenmc03_1903 Bcenmc03_1977
BCJ: BCAL1951(glxR) BCAL2026
BAM: Bamb_1817 Bamb_1940
BAC: BamMC406_1789 BamMC406_1867
BMU: Bmul_1316 Bmul_1394
BMJ: BMULJ_01849(garR) BMULJ_01930(garR)
BXE: Bxe_A2462 Bxe_B0972 Bxe_C0957
BPH: Bphy_1286 Bphy_1622 Bphy_6215 Bphy_6528
BPY: Bphyt_1780 Bphyt_4859
PNU: Pnuc_0594 Pnuc_0958
BPA: BPP3639
BBR: BB2674 BB4074
BAV: BAV2903(glxR)
RFR: Rfer_0430 Rfer_3038
POL: Bpro_0394 Bpro_1712 Bpro_3102 Bpro_4563
PNA: Pnap_0274 Pnap_1600
VEI: Veis_1704
DAC: Daci_2119
MPT: Mpe_A0975 Mpe_A2972
HAR: HEAR0217 HEAR0334(glxR)
MMS: mma_0270(garR1) mma_0381(garR2)
LCH: Lcho_1123 Lcho_1133
NEU: NE0676
NET: Neut_1881
NMU: Nmul_A0172
EBA: ebA3883(tsaR)
AZO: azo3362(glxR1) azo3363(glxR2)
TMZ: Tmz1t_1297
TBD: Tbd_0081
APP: CAP2UW1_2635
GUR: Gura_0588 Gura_2805
GEM: GM21_0331
PPD: Ppro_2197
DVM: DvMF_2927(garR)
PUB: SAR11_0778(gnd)
MES: Meso_2516 Meso_4460
SME: SM_b20679(glxR) SMa0237
SMD: Smed_2487 Smed_4310 Smed_5561
ATU: Atu2737
ATC: AGR_C_4961
ARA: Arad_3557 Arad_9669
AVI: Avi_5035(garR) Avi_5720
RLE: RL2772 RL3773 RL3800
RLT: Rleg2_3094 Rleg2_4513
RLG: Rleg_3351 Rleg_3379
OAN: Oant_0460 Oant_3760
BJA: blr3168
BRA: BRADO6761(garR)
OCA: OCAR_6560
XAU: Xaut_2369 Xaut_2433
AZC: AZC_2610 AZC_3490
MRD: Mrad2831_1777
MET: M446_6206
MNO: Mnod_3089 Mnod_7094 Mnod_8654
SIL: SPO2560(garR)
RDE: RD1_0672(garR) RD1_0684(glxR)
DSH: Dshi_4221
SWI: Swit_3270
GBE: GbCGDNIH1_0961
ACR: Acry_1159 Acry_1592
BCA: BCE_2381(garR) BCE_4109
BCR: BCAH187_A2454
BCB: BCB4264_A2319
BCU: BCAH820_2372
BLD: BLi02105
CPF: CPF_0381(garR)
CDF: CD2813(garR)
CBT: CLH_1483
AMT: Amet_2959(garR)
DSY: DSY4169(garR)
DHD: Dhaf_1173
EEL: EUBELI_01262
MSM: MSMEG_5477
RHA: RHA1_ro02575 RHA1_ro03224 RHA1_ro04661
SCO: SCO6205(SC2G5.26c)
SMA: SAV_2025(garR)
ART: Arth_2453 Arth_3602 Arth_3690
AAU: AAur_2423 AAur_3507
KRH: KRH_00810
TFU: Tfu_1265
ACE: Acel_1045
SEN: SACE_1936 SACE_5376(glxR) SACE_6730
RXY: Rxyl_1714 Rxyl_2852
ABA: Acid345_1903
SUS: Acid_3982(garR)
SYW: SYNW2331
SYE: Syncc9902_2145
AVA: Ava_3206
TRO: trd_A0460
DGE: Dgeo_2614
HUT: Huta_0338
PTO: PTO1147
Taxonomy
Structures PDB: 1YB4  
Reference
  Authors
  Title

  Journal
  Organism
 1  [PMID:13900766]
GOTTO AM, KORNBERG HL.
The metabolism of C2 compounds in micro-organisms. 7. Preparation
and properties of crystalline tartronic semialdehyde reductase.
Biochem. J. 81 (1961) 273-84.
Pseudomonas ovalis
Other DBs ExplorEnz - The Enzyme Database: 1.1.1.60
IUBMB Enzyme Nomenclature: 1.1.1.60
ExPASy - ENZYME nomenclature database: 1.1.1.60
BRENDA, the Enzyme Database: 1.1.1.60
CAS: 9028-68-6
DBGET integrated database retrieval system