KEGG   ENZYME: 1.1.1.62Help
Entry
EC 1.1.1.62                 Enzyme                                 

Name
17beta-estradiol 17-dehydrogenase;
20alpha-hydroxysteroid dehydrogenase;
17beta,20alpha-hydroxysteroid dehydrogenase;
17beta-estradiol dehydrogenase;
estradiol dehydrogenase;
estrogen 17-oxidoreductase;
17beta-HSD;
HSD17B7
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
17beta-estradiol:NAD(P)+ 17-oxidoreductase
Reaction(IUBMB)
17beta-estradiol + NAD(P)+ = estrone + NAD(P)H + H+ [RN:R02352 R02353]
Reaction(KEGG)
Substrate
17beta-estradiol;
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
estrone [CPD:C00468];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme oxidizes or reduces the hydroxy/keto group on C17 of estrogens and androgens in mammals and regulates the biological potency of these steroids. The mammalian enzyme is bifunctional and also catalyses EC 1.1.1.270, 3beta-hydroxysteroid 3-dehydrogenase [3]. The enzyme also acts on (S)-20-hydroxypregn-4-en-3-one and related compounds, oxidizing the (S)-20-group, but unlike EC 1.1.1.149, 20alpha-hydroxysteroid dehydrogenase, it is Si-specific with respect to NAD(P)+.
History
EC 1.1.1.62 created 1965, modified 1983, modified 1986, modified 2012
Pathway
Steroid hormone biosynthesis
Metabolic pathways
Orthology
K00044  
17beta-estradiol 17-dehydrogenase
K10251  
17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase
K13368  
17beta-estradiol 17-dehydrogenase / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
K13369  
17beta-estradiol 17-dehydrogenase / all-trans-retinol dehydrogenase (NAD+) / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
K13370  
17beta-estradiol 17-dehydrogenase / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
K13373  
17beta-estradiol 17-dehydrogenase / 3beta-hydroxysteroid 3-dehydrogenase
Genes
HSA: 
3292(HSD17B1) 3294(HSD17B2) 51144(HSD17B12) 51478(HSD17B7) 7923(HSD17B8) 8630(HSD17B6)
PTR: 
100614183 454269(HSD17B2) 454689(HSD17B1) 466046 741010(HSD17B12) 746685(HSD17B8) 747814(HSD17B7)
PPS: 
100971612(HSD17B12) 100983435(HSD17B2) 100984876 100985156(HSD17B7) 100993294(HSD17B8) 100994126 100996145(HSD17B6)
GGO: 
101125069 101126579(HSD17B12) 101131453(HSD17B2) 101137638 101139911 101143846(HSD17B8) 101153072(HSD17B6)
PON: 
100439025(HSD17B12) 100446761(HSD17B7) 100456547(HSD17B2) 100456666 100458219(HSD17B6) 100461538(HSD17B8)
MCC: 
710392(HSD17B1) 713549(HSD17B6) 714282 718119(HSD17B8) 720399
MCF: 
101867269(HSD17B12) 101926544 102119721(HSD17B2) 102122077(HSD17B1) 102127673(HSD17B7) 102134563(HSD17B8)
MMU: 
14979(H2-Ke6) 15485(Hsd17b1) 15486(Hsd17b2) 15490(Hsd17b7) 27400(Hsd17b6) 56348(Hsd17b12)
RNO: 
100362350 25322(Hsd17b1) 286964(Hsd17b6) 29540(Hsd17b7) 361802(Hsd17b8) 79243(Hsd17b2) 84013(Hsd17b12)
CGE: 
100750866(Hsd17b1) 100751291(Hsd17b12) 100751897(Hsd17b2) 100762147(Hsd17b6) 100766230(Hsd17b8) 100767580(Hsd17b7)
HGL: 
101699287(Hsd17b6) 101712707(Hsd17b7) 101717552(Hsd17b12) 101719685(Hsd17b2) 101720493(Hsd17b1) 101726130(Hsd17b8)
TUP: 
102473205(HSD17B7) 102481564(HSD17B2) 102482283(HSD17B1) 102485005(HSD17B6) 102494154(HSD17B8) 102495234(HSD17B12)
CFA: 
475939(HSD17B12) 481118(HSD17B6) 489690(HSD17B2) 607570(HSD17B1) 607895(HSD17B8) 609364(HSD17B7)
AML: 
FCA: 
101082595(HSD17B12) 101083482(HSD17B7) 101085592(HSD17B2) 101086309(HSD17B8) 101088341(HSD17B6) 101091417(HSD17B1)
PTG: 
102958819(HSD17B2) 102958840(HSD17B1) 102963001(HSD17B12) 102968316(HSD17B7) 102968797(HSD17B8) 102971783(HSD17B6)
BTA: 
353107(HSD17B1) 505212(HSD17B7) 515710(HSD17B2) 532422(HSD17B8) 533086(HSD17B6) 785989(HSD17B1) 789567(HSD17B12)
BOM: 
102266348(HSD17B7) 102274407(HSD17B12) 102278627 102278674(HSD17B2) 102281071(HSD17B1) 102283510(HSD17B6) 102286352(HSD17B8)
PHD: 
102315709 102316552(HSD17B7) 102323155 102327736(HSD17B1) 102332625(HSD17B6) 102336871(HSD17B2) 102340413(HSD17B8) 102344762
CHX: 
102169696 102179058(HSD17B7) 102182621(HSD17B2) 102182909(HSD17B1) 102185066(HSD17B6) 102186887(HSD17B12) 102189913(HSD17B8)
SSC: 
100147712(HSD17B1) 100154372(HSD17B8) 100155418(HSD17B7) 100312972(HSD17B12) 100312973(HSD17B2) 100620470(HSD17B6)
CFR: 
102504651(HSD17B8) 102508382 102512546(HSD17B7) 102514993(HSD17B2) 102515430(HSD17B12) 102523786(HSD17B1)
BACU: 
102998439(HSD17B12) 103006419(HSD17B8) 103008169(HSD17B6) 103014202(HSD17B2) 103014331(HSD17B7) 103017434 103019221
LVE: 
103068441(HSD17B12) 103070082(HSD17B1) 103070446(HSD17B2) 103076064(HSD17B6) 103084050(HSD17B7) 103088201(HSD17B8)
ECB: 
100036556(HSD17B1) 100050075(HSD17B12) 100052840(HSD17B6) 100059061(HSD17B7) 100061414(HSD17B8) 100146214(HSD17B2)
MYB: 
102251181(HSD17B7) 102252900(HSD17B8) 102256830(HSD17B1) 102260774(HSD17B2) 102263627(HSD17B12)
MYD: 
102751454(HSD17B2) 102763053(HSD17B1) 102766664(HSD17B8) 102766960(HSD17B12) 102767046(HSD17B7)
PALE: 
102882881(HSD17B2) 102883634(HSD17B6) 102889386(HSD17B12) 102889883(HSD17B8) 102892079(HSD17B7) 102898145(HSD17B1)
MDO: 
100011776(HSD17B1) 100013277(HSD17B12) 100016071(HSD17B7) 100025234(HSD17B8) 100031815
SHR: 
OAA: 
100076931(HSD17B2) 100079057(HSD17B12)
GGA: 
395641(HSD17B1) 415807(HSD17B2) 424367(HSD17B7) 769787(HSD17B12)
MGP: 
TGU: 
100222823(HSD17B7) 100223843(HSD17B12) 100228039(HSD17B2) 100231423
FAB: 
101807632 101810836(HSD17B1) 101810951(HSD17B2) 101818521(HSD17B7)
PHI: 
102100450(HSD17B1) 102103079(HSD17B2) 102106801(HSD17B12) 102107312(HSD17B7)
APLA: 
101792379(HSD17B2) 101799136(HSD17B7) 101803586(HSD17B12)
FPG: 
101915382(HSD17B2) 101917180(HSD17B12) 101919410(HSD17B7)
FCH: 
102048922(HSD17B2) 102056639(HSD17B12) 102059217(HSD17B7)
CLV: 
102085015(HSD17B12) 102095570(HSD17B2) 102097738(HSD17B7)
ASN: 
AMJ: 
102559362(HSD17B12) 102564718(HSD17B1) 102565865(HSD17B7) 102567845 102568488(HSD17B8) 102571332 102572659 102574309(HSD17B2)
PSS: 
CMY: 
102929636(HSD17B8) 102938030(HSD17B12) 102939820 102941631(HSD17B2) 102942502(HSD17B1) 102944543(HSD17B6) 102944731(HSD17B7)
ACS: 
PBI: 
103049647(HSD17B12) 103058540(HSD17B2) 103063132(HSD17B7) 103063622
XLA: 
379747(hsd17b12-b) 398882(rdh16) 495218(hsd17b12-a) 734717(hsd17b7)
XTR: 
100127828 100135184(rdh16) 100489679 100497002(hsd17b2) 548963(hsd17b7) 549425(hsd17b8) 549988(hsd17b12)
DRE: 
100332819 322626(hsd17b12b) 327417(hsd17b12a) 402842(hsd17b1) 449537(hsd17b2) 64815(hsd17b8) 768185(hsd17b7)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102348492(HSD17B7) 102348665 102360275(HSD17B2) 102361445(HSD17B8) 102362094 102364827(HSD17B1)
CMK: 
103174968(hsd17b12) 103180036(hsd17b7) 103191276
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AAG: 
CQU: 
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CBR: 
CBG18334(Cbr-dhs-11)
LOA: 
TSP: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
ATH: 
AT1G67730(KCR1)
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
MTR: 
CAM: 
FVE: 
PPER: 
CSV: 
RCU: 
POP: 
POPTR_0008s18190g(POPTRDRAFT_565101) POPTR_0010s06220g(POPTRDRAFT_821856) POPTR_0010s06230g(POPTRDRAFT_769035) POPTR_0010s06240g(POPTRDRAFT_565949)
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os04t0116600-01(Os04g0116600) Os04t0483500-01(Os04g0483500) Os06t0298700-00(Os06g0298700) Os06t0300200-00(Os06g0300200)
OBR: 
BDI: 
SBI: 
SORBI_01g035200(SORBIDRAFT_01g035200) SORBI_01g047620(SORBIDRAFT_01g047620) SORBI_04g025020(SORBIDRAFT_04g025020) SORBI_06g020580(SORBIDRAFT_06g020580) SORBI_06g020600(SORBIDRAFT_06g020600) SORBI_10g010930(SORBIDRAFT_10g010930) SORBI_10g010960(SORBIDRAFT_10g010960) SORBI_10g010990(SORBIDRAFT_10g010990) SORBI_10g011020(SORBIDRAFT_10g011020)
ZMA: 
542359(gl8)
SITA: 
ATR: 
s00049p00175350(AMTR_s00049p00175350) s00049p00175530(AMTR_s00049p00175530) s00049p00175800(AMTR_s00049p00175800)
SMO: 
PPP: 
CSL: 
CVR: 
CME: 
GSL: 
CCP: 
SCE: 
YBR159W(IFA38)
AGO: 
ERC: 
KLA: 
LTH: 
PPA: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0B02360(NCAS0B02360)
NDI: 
NDAI_0C05330(NDAI0C05330)
TPF: 
TPHA_0L01460(TPHA0L01460)
TBL: 
TBLA_0H03430(TBLA0H03430)
TDL: 
TDEL_0B01260(TDEL0B01260)
KAF: 
KAFR_0E03020(KAFR0E03020)
DHA: 
PIC: 
PGU: 
LEL: 
SPAA: 
CAL: 
CTP: 
CDU: 
COT: 
CTEN: 
YLI: 
CLU: 
NCR: 
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
TMN: 
FGR: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
VAL: 
ELA: 
SSL: 
BFU: 
MBE: 
ANI: 
AFM: 
AOR: 
AOR_1_900014(AO090026000492)
ANG: 
ANI_1_488024(An02g03570)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
PBL: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
BZE: 
ZTR: 
PFJ: 
BCOM: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
PPL: 
LBC: 
MPR: 
CCI: 
SCM: 
UMA: 
MGL: 
PGR: 
EIN: 
NCE: 
MBR: 
DDI: 
DPP: 
DFA: 
EHI: 
EHI_165070(127.t00009)
EDI: 
PCB: 
PVX: 
PCY: 
TGO: 
PTI: 
TPS: 
PIF: 
EHX: 
GTT: 
TCR: 
LMA: 
LIF: 
LDO: 
LMI: 
LBZ: 
NGR: 
GLA: 
 » show all
Taxonomy
Reference
1  [PMID:4314937]
  Authors
Kautsky MP, Hagerman DD.
  Title
17 Beta-estradiol dehydrogenase of ovine ovaries.
  Journal
J. Biol. Chem. 245 (1970) 1978-84.
  Organism
Ovis aries
Reference
2  [PMID:14413943]
  Authors
LANGER LJ, ALEXANDER JA, ENGEL LL.
  Title
Human placental estradiol-17 beta dehydrogenase. II. Kinetics and substrate specificities.
  Journal
J. Biol. Chem. 234 (1959) 2609-14.
  Organism
Homo sapiens
Reference
3  [PMID:12829805]
  Authors
Marijanovic Z, Laubner D, Moller G, Gege C, Husen B, Adamski J, Breitling R
  Title
Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis.
  Journal
Mol. Endocrinol. 17 (2003) 1715-25.
  Organism
Homo sapiens
  Sequence
[hsa:51478]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9028-61-9

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