| Entry |
|
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| Name |
testosterone 17beta-dehydrogenase;
17-ketoreductase;
17beta-HSD |
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| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
 |
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| Sysname |
17beta-hydroxysteroid:NAD+ 17-oxidoreductase |
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| Reaction(IUBMB) |
testosterone + NAD+ = androst-4-ene-3,17-dione + NADH + H+
[RN:R01836] |
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| Reaction(KEGG) |
R01836
 |
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| Substrate |
testosterone [CPD:C00535];
NAD+ [CPD:C00003] |
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| Product |
androst-4-ene-3,17-dione [CPD:C00280];
NADH [CPD:C00004];
H+ [CPD:C00080] |
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| Pathway |
PATH: ec00140 Steroid hormone biosynthesis
PATH: ec01100 Metabolic pathways |
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| Orthology |
KO: K13368 estradiol 17beta-dehydrogenase / testosterone
17beta-dehydrogenase
KO: K13369 estradiol 17beta-dehydrogenase / testosterone
17beta-dehydrogenase / retinol dehydrogenase
KO: K13370 estradiol 17beta-dehydrogenase / testosterone
17beta-dehydrogenase / |
|---|
| Genes |
HSA: 3294(HSD17B2) 7923(HSD17B8) 8630(HSD17B6)
PTR: 454269(HSD17B2) 746685(HSD17B8)
MCC: 713549 714282 718119(HSD17B8)
MMU: 14979(H2-Ke6) 15486(Hsd17b2) 27400(Hsd17b6)
RNO: 286964(Hsd17b6) 361802(Hsd17b8) 79243(Hsd17b2)
CFA: 481118(HSD17B6) 489690(HSD17B2) 607895(HSD17B8)
BTA: 515710(HSD17B2) 532422(HSD17B8) 533086(HSD17B6)
SSC: 100154372(SBAB-279G2.1)
ECB: 100052840 100061414 100146214
MDO: 100025234 100031815
OAA: 100076931
GGA: 415807(HSD17B2)
TGU: 100228039
XTR: 549425(hsd17b8)
DRE: 64815(hsd17b8)
 |
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Reference
Authors
Title
Journal
Organism
|
1 [PMID:13696735]
ENDAHL GL, KOCHAKIAN CD, HAMM D.
Separation of a triphosphopyridine nucleotide-specific from a
diphosphopyridine nucleotide-specific 17 beta-hydroxy-(testosterone)
dehydrogenase of guinea pig liver.
J. Biol. Chem. 235 (1960) 2792-6.
Cavia porcellus |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:15436478]
SWEAT ML, SAMUELS LT, LUMRY R.
Preparation and characterization of the enzyme which converts
testosterone to androstenedione.
J. Biol. Chem. 185 (1950) 75-84.
Bos taurus [GN:bta] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:13781425]
VILLEE CA, SPENCER JM.
Some properties of the pyridine nucleotide-specific 17 beta-hydroxy
steroid dehydrogenases of guinea pig liver.
J. Biol. Chem. 235 (1960) 3615-9.
Cavia porcellus |
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| Other DBs |
ExplorEnz - The Enzyme Database: 1.1.1.63
IUBMB Enzyme Nomenclature: 1.1.1.63
ExPASy - ENZYME nomenclature database: 1.1.1.63
BRENDA, the Enzyme Database: 1.1.1.63
CAS: 9028-62-0 |
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