| Entry |
|
|---|
| Name |
testosterone 17beta-dehydrogenase (NADP+);
17-ketoreductase;
NADP-dependent testosterone-17beta-oxidoreductase;
testosterone 17beta-dehydrogenase (NADP) |
|---|
| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
17beta-hydroxysteroid:NADP+ 17-oxidoreductase |
|---|
| Reaction(IUBMB) |
testosterone + NADP+ = androst-4-ene-3,17-dione + NADPH + H+
[RN:R01838] |
|---|
| Reaction(KEGG) |
R01838
 |
|---|
| Substrate |
testosterone [CPD:C00535];
NADP+ [CPD:C00006] |
|---|
| Product |
androst-4-ene-3,17-dione [CPD:C00280];
NADPH [CPD:C00005];
H+ [CPD:C00080] |
|---|
| Comment |
Also oxidizes 3-hydroxyhexobarbital to 3-oxohexobarbital. |
|---|
| Pathway |
PATH: ec00140 Steroid hormone biosynthesis
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K10207 testosterone 17beta-dehydrogenase (NADP+) |
|---|
| Genes |
HSA: 3293(HSD17B3)
PTR: 742116(HSD17B3)
MCC: 709843(HSD17B3)
MMU: 15487(Hsd17b3)
RNO: 117182(Hsd17b3)
CFA: 606956(HSD17B3)
BTA: 616934(HSD17B3)
ECB: 100062795
DRE: 393335(hsd17b3)
TET: TTHERM_00706280
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:13696735]
ENDAHL GL, KOCHAKIAN CD, HAMM D.
Separation of a triphosphopyridine nucleotide-specific from a
diphosphopyridine nucleotide-specific 17 beta-hydroxy-(testosterone)
dehydrogenase of guinea pig liver.
J. Biol. Chem. 235 (1960) 2792-6.
Cavia porcellus |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:15436478]
SWEAT ML, SAMUELS LT, LUMRY R.
Preparation and characterization of the enzyme which converts
testosterone to androstenedione.
J. Biol. Chem. 185 (1950) 75-84.
Bos taurus [GN:bta] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:13781425]
VILLEE CA, SPENCER JM.
Some properties of the pyridine nucleotide-specific 17 beta-hydroxy
steroid dehydrogenases of guinea pig liver.
J. Biol. Chem. 235 (1960) 3615-9.
Cavia porcellus |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.1.1.64
IUBMB Enzyme Nomenclature: 1.1.1.64
ExPASy - ENZYME nomenclature database: 1.1.1.64
BRENDA, the Enzyme Database: 1.1.1.64
CAS: 9028-63-1 |
|---|
