KEGG   ENZYME: 1.1.1.64Help
Entry
EC 1.1.1.64                 Enzyme                                 

Name
testosterone 17beta-dehydrogenase (NADP+);
17-ketoreductase;
NADP-dependent testosterone-17beta-oxidoreductase;
testosterone 17beta-dehydrogenase (NADP)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
17beta-hydroxysteroid:NADP+ 17-oxidoreductase
Reaction(IUBMB)
testosterone + NADP+ = androstenedione + NADPH + H+ [RN:R01838]
Reaction(KEGG)
Substrate
testosterone [CPD:C00535];
NADP+ [CPD:C00006]
Product
androstenedione [CPD:C00280];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Also oxidizes 3-hydroxyhexobarbital to 3-oxohexobarbital.
History
EC 1.1.1.64 created 1965
Pathway
Steroid hormone biosynthesis
Metabolic pathways
Orthology
K10207  
testosterone 17beta-dehydrogenase (NADP+)
Genes
HSA: 
3293(HSD17B3)
PTR: 
742116(HSD17B3)
PPS: 
100972788(HSD17B3)
GGO: 
101137034(HSD17B3)
PON: 
100433175(HSD17B3)
NLE: 
100584015(HSD17B3)
MCC: 
709843(HSD17B3)
MCF: 
102126699(HSD17B3)
RRO: 
104658189(HSD17B3)
CJC: 
100414334(HSD17B3)
MMU: 
15487(Hsd17b3)
RNO: 
117182(Hsd17b3)
CGE: 
100767644(Hsd17b3)
NGI: 
103751616(Hsd17b3)
HGL: 
101712135(Hsd17b3)
OCU: 
100346075(HSD17B3)
TUP: 
102477731(HSD17B3)
CFA: 
100856708(HSD17B3)
AML: 
100468038(HSD17B3)
UMR: 
103682216(HSD17B3)
FCA: 
101085324(HSD17B3)
PTG: 
102972770(HSD17B3)
BTA: 
616934(HSD17B3)
BOM: 
102284785(HSD17B3)
PHD: 
102341291(HSD17B3)
CHX: 
102188501(HSD17B3)
OAS: 
101111157(HSD17B3)
SSC: 
100513224(HSD17B3)
CFR: 
102514822(HSD17B3)
BACU: 
103006772(HSD17B3)
LVE: 
103087691(HSD17B3)
ECB: 
100062795(HSD17B3)
MYB: 
102256012(HSD17B3)
MYD: 
102755784(HSD17B3)
PALE: 
102883847(HSD17B3)
MDO: 
100014335(HSD17B3)
SHR: 
100935109(HSD17B3)
GGA: 
427474(HSD17B3)
CJO: 
107306280(HSD17B3)
APLA: 
101797428(HSD17B3)
GFR: 
106631948(HSD17B3)
FAB: 
107604273(HSD17B3)
FPG: 
101920192(HSD17B3)
FCH: 
102057185(HSD17B3)
CLV: 
102098536(HSD17B3)
AAM: 
ASN: 
102387576(HSD17B3)
AMJ: 
102576225(HSD17B3)
PSS: 
102451036(HSD17B3)
CMY: 
102936343(HSD17B3)
ACS: 
100561157(hsd17b3)
PBI: 
103062335(HSD17B3)
GJA: 
107111659(HSD17B3)
XTR: 
101730254(hsd17b3)
DRE: 
393335(hsd17b3)
TRU: 
101070933(hsd17b3)
MZE: 
101468772(hsd17b3)
OLA: 
100125485(hsd17b3)
XMA: 
102216624(hsd17b3)
LCM: 
102364217(HSD17B3)
CMK: 
103182831(hsd17b3)
 » show all
Taxonomy
Reference
1  [PMID:13696735]
  Authors
ENDAHL GL, KOCHAKIAN CD, HAMM D.
  Title
Separation of a triphosphopyridine nucleotide-specific from a diphosphopyridine nucleotide-specific 17 beta-hydroxy-(testosterone) dehydrogenase of guinea pig liver.
  Journal
J. Biol. Chem. 235 (1960) 2792-6.
Reference
2  [PMID:15436478]
  Authors
SWEAT ML, SAMUELS LT, LUMRY R.
  Title
Preparation and characterization of the enzyme which converts testosterone to androstenedione.
  Journal
J. Biol. Chem. 185 (1950) 75-84.
Reference
3  [PMID:13781425]
  Authors
VILLEE CA, SPENCER JM.
  Title
Some properties of the pyridine nucleotide-specific 17 beta-hydroxy steroid dehydrogenases of guinea pig liver.
  Journal
J. Biol. Chem. 235 (1960) 3615-9.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9028-63-1

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