KEGG   ENZYME: 1.1.1.8Help
Entry
EC 1.1.1.8                  Enzyme                                 

Name
glycerol-3-phosphate dehydrogenase (NAD+);
alpha-glycerol phosphate dehydrogenase (NAD+);
alpha-glycerophosphate dehydrogenase (NAD+);
glycerol 1-phosphate dehydrogenase;
glycerol phosphate dehydrogenase (NAD+);
glycerophosphate dehydrogenase (NAD+);
hydroglycerophosphate dehydrogenase;
L-alpha-glycerol phosphate dehydrogenase;
L-alpha-glycerophosphate dehydrogenase;
L-glycerol phosphate dehydrogenase;
L-glycerophosphate dehydrogenase (ambiguous);
NAD+-alpha-glycerophosphate dehydrogenase;
NAD+-dependent glycerol phosphate dehydrogenase;
NAD+-dependent glycerol-3-phosphate dehydrogenase;
NAD+-L-glycerol-3-phosphate dehydrogenase;
NAD+-linked glycerol 3-phosphate dehydrogenase;
NADH-dihydroxyacetone phosphate reductase;
glycerol-3-phosphate dehydrogenase (NAD+);
L-glycerol-3-phosphate dehydrogenase (ambiguous)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
sn-glycerol-3-phosphate:NAD+ 2-oxidoreductase
Reaction(IUBMB)
sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+ [RN:R00842]
Reaction(KEGG)
Substrate
sn-glycerol 3-phosphate [CPD:C00093];
NAD+ [CPD:C00003]
Product
glycerone phosphate [CPD:C00111];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Also acts on propane-1,2-diol phosphate and glycerone sulfate (but with a much lower affinity).
History
EC 1.1.1.8 created 1961, modified 2005
Pathway
Glycerophospholipid metabolism
Orthology
K00006  
glycerol-3-phosphate dehydrogenase (NAD+)
Genes
HSA: 
23171(GPD1L) 2819(GPD1)
PTR: 
741054(GPD1)
PPS: 
100981359(GPD1) 100983363(GPD1L)
GGO: 
101131184(GPD1) 101153797(GPD1L)
PON: 
100172201(GPD1) 100173675(GPD1L)
MCC: 
MCF: 
MMU: 
14555(Gpd1) 333433(Gpd1l)
RNO: 
363159(Gpd1l) 60666(Gpd1)
CGE: 
100772179(Gpd1) 100773663(Gpd1l)
HGL: 
101702723(Gpd1) 101707148(Gpd1l)
TUP: 
102482961(GPD1) 102497326(GPD1L)
CFA: 
485626(GPD1L) 607942(GPD1)
AML: 
FCA: 
101086577(GPD1) 101093135(GPD1L)
PTG: 
102953262(GPD1L) 102961238(GPD1)
BTA: 
514456(GPD1L) 525042(GPD1)
BOM: 
PHD: 
CHX: 
OAS: 
101104692(GPD1L) 101119894(GPD1)
SSC: 
100153250(GPD1) 100624347(GPD1L)
CFR: 
BACU: 
LVE: 
ECB: 
100052204(GPD1) 100057124(GPD1L)
MYB: 
102243576(GPD1L) 102257341(GPD1)
MYD: 
102754955(GPD1) 102768327(GPD1L)
PALE: 
102880604(GPD1) 102882609(GPD1L)
MDO: 
SHR: 
OAA: 
100077586(GPD1L) 100085954(GPD1)
GGA: 
420664(GPD1L) 424263(GPD1) 426881
MGP: 
APLA: 
TGU: 
FAB: 
PHI: 
FPG: 
FCH: 
CLV: 
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
PBI: 
XLA: 
379962(gpd1l) 399227(gpd1) 444456
XTR: 
394623(gpd1l) 448519(gpd1)
DRE: 
325181(gpd1b) 406615(gpd1c) 449663(gpd1l) 550404(gpd1a)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
NVI: 
TCA: 
BMOR: 
692517(G3pdh-1)
API: 
PHU: 
ISC: 
CEL: 
CELE_F47G4.3(gpdh-1) CELE_K11H3.1(gpdh-2)
CBR: 
CBG09958(Cbr-gpdh-2) CBG18871(Cbr-gpdh-1)
BMY: 
LOA: 
TSP: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
ATH: 
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
MTR: 
CAM: 
FVE: 
PPER: 
PMUM: 
MDM: 
CSV: 
CMO: 
RCU: 
POP: 
POPTR_0017s10710g(POPTRDRAFT_908191)
VVI: 
SLY: 
SOT: 
DOSA: 
Os01t0971600-01(Os01g0971600)
OBR: 
BDI: 
SBI: 
SORBI_03g047310(SORBIDRAFT_03g047310)
ZMA: 
SITA: 
ATR: 
s00049p00131690(AMTR_s00049p00131690)
SMO: 
PPP: 
CRE: 
VCN: 
CSL: 
CVR: 
CME: 
GSL: 
CCP: 
SCE: 
YDL022W(GPD1) YOL059W(GPD2)
AGO: 
ERC: 
KLA: 
LTH: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0C03620(NCAS0C03620) NCAS_0I02050(NCAS0I02050)
NDI: 
NDAI_0A06640(NDAI0A06640) NDAI_0G02970(NDAI0G02970)
TPF: 
TPHA_0H00810(TPHA0H00810) TPHA_0P00620(TPHA0P00620)
TBL: 
TBLA_0B01610(TBLA0B01610) TBLA_0F00800(TBLA0F00800)
TDL: 
TDEL_0D04540(TDEL0D04540)
KAF: 
KAFR_0C01000(KAFR0C01000) KAFR_0F02240(KAFR0F02240)
PPA: 
DHA: 
PIC: 
PGU: 
SPAA: 
LEL: 
CAL: 
CaO19.1756(GPD1) CaO19.691(GPD2) CaO19.8310(GPD2) CaO19.9325(GPD1)
CTP: 
COT: 
CDU: 
CTEN: 
YLI: 
CLU: 
NCR: 
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
TMN: 
FGR: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
VAL: 
ELA: 
SSL: 
BFU: 
MBE: 
ANI: 
AFM: 
AOR: 
AOR_1_1486054(AO090011000879) AOR_1_1546174(AO090005000883)
ANG: 
ANI_1_1768134(An15g07390) ANI_1_786014(An01g06110)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
PBL: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
BCOM: 
NPA: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
TMS: 
MPR: 
MRR: 
SCM: 
UMA: 
PFP: 
MGL: 
MLR: 
WSE: 
WALSEDRAFT_33541(GPD1/GPD2)
ECU: 
EIN: 
EHE: 
NCE: 
ACAN: 
PFA: 
PFD: 
PFH: 
PYO: 
PCB: 
PBE: 
PKN: 
PVX: 
PCY: 
TAN: 
TPV: 
BBO: 
BBOV_IV004480(23.m06005)
BEQ: 
CPV: 
CHO: 
TGO: 
PTI: 
TPS: 
PIF: 
EHX: 
GTT: 
TBR: 
Tb927.8.3530(Tb08.28L1.740)
LMA: 
LIF: 
LDO: 
LMI: 
LBZ: 
TVA: 
 » show all
Taxonomy
Reference
1
  Authors
Baranowski, T.
  Title
alpha-Glycerophosphate dehydrogenase.
  Journal
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 85-96.
Reference
2  [PMID:4307630]
  Authors
Brosemer RW, Kuhn RW.
  Title
Comparative structural properties of honeybee and rabbit alpha-glycerophosphate dehydrogenases.
  Journal
Biochemistry. 8 (1969) 2095-105.
Reference
3  [PMID:4340553]
  Authors
O'Brien SJ, MacIntyre RJ.
  Title
The  -glycerophosphate cycle in Drosophila melanogaster. I. Biochemical and developmental aspects.
  Journal
Biochem. Genet. 7 (1972) 141-61.
Reference
4  [PMID:4200180]
  Authors
Warkentin DL, Fondy TP.
  Title
Isolation and characterization of cytoplasmic L-glycerol-3-phosphate dehydrogenase from rabbit-renal-adipose tissue and its comparison with the skeletal-muscle enzyme.
  Journal
Eur. J. Biochem. 36 (1973) 97-109.
Reference
5  [PMID:1499720]
  Authors
Albertyn J, van Tonder A, Prior BA.
  Title
Purification and characterization of glycerol-3-phosphate dehydrogenase of Saccharomyces cerevisiae.
  Journal
FEBS. Lett. 308 (1992) 130-2.
Reference
6  [PMID:7671141]
  Authors
Koekemoer TC, Litthauer D, Oelofsen W.
  Title
Isolation and characterization of adipose tissue glycerol-3-phosphate dehydrogenase.
  Journal
Int. J. Biochem. Cell. Biol. 27 (1995) 625-32.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9075-65-4

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