| Entry |
|
|---|
| Name |
dimethylmalate dehydrogenase;
beta,beta-dimethylmalate dehydrogenase |
|---|
| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
(R)-3,3-dimethylmalate:NAD+ oxidoreductase (decarboxylating) |
|---|
| Reaction(IUBMB) |
(R)-3,3-dimethylmalate + NAD+ = 3-methyl-2-oxobutanoate + CO2 + NADH
[RN:R01211] |
|---|
| Reaction(KEGG) |
R01211
 |
|---|
| Substrate |
(R)-3,3-dimethylmalate [CPD:C01088];
NAD+ [CPD:C00003] |
|---|
| Product |
3-methyl-2-oxobutanoate [CPD:C00141];
CO2 [CPD:C00011];
NADH [CPD:C00004] |
|---|
| Cofactor |
NH3 [CPD:C00014];
Manganese [CPD:C00034];
Cobalt ion [CPD:C00175];
Potassium [CPD:C00238];
NH4+ [CPD:C01342] |
|---|
| Comment |
Requires K+ or NH4+ and Mn2+ or Co2+; also acts on (R)-malate. |
|---|
| Pathway |
PATH: ec00770 Pantothenate and CoA biosynthesis |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:4287371]
Magee PT, Snell EE.
The bacterial degradation of pantothenic acid. IV. Enzymatic
conversion of aldopantoate to alpha-ketoisovalerate.
Biochemistry. 5 (1966) 409-16.
Pseudomonas sp. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.1.1.84
IUBMB Enzyme Nomenclature: 1.1.1.84
ExPASy - ENZYME nomenclature database: 1.1.1.84
BRENDA, the Enzyme Database: 1.1.1.84
CAS: 37250-21-8 |
|---|
