| Entry |
|
|---|
| Name |
3-isopropylmalate dehydrogenase;
beta-isopropylmalic enzyme;
beta-isopropylmalate dehydrogenase;
threo-Ds-3-isopropylmalate dehydrogenase;
3-carboxy-2-hydroxy-4-methylpentanoate:NAD+ oxidoreductase |
|---|
| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
(2R,3S)-3-isopropylmalate:NAD+ oxidoreductase |
|---|
| Reaction(IUBMB) |
(1) (1a) (2R,3S)-3-isopropylmalate + NAD+ =
(2S)-2-isopropyl-3-oxosuccinate + NADH + H+ [RN:R04426];
(2) (1b) (2S)-2-isopropyl-3-oxosuccinate = 4-methyl-2-oxopentanoate
+ CO2 (spontaneous) |
|---|
| Reaction(KEGG) |
R04426;
(other) R00994
 |
|---|
| Substrate |
(2R,3S)-3-isopropylmalate [CPD:C04411];
NAD+ [CPD:C00003];
(2S)-2-isopropyl-3-oxosuccinate [CPD:C04236] |
|---|
| Product |
(2S)-2-isopropyl-3-oxosuccinate [CPD:C04236];
NADH [CPD:C00004];
H+ [CPD:C00080];
4-methyl-2-oxopentanoate [CPD:C00233];
CO2 [CPD:C00011] |
|---|
| Comment |
The product decarboxylates spontaneously to yield
4-methyl-2-oxopentanoate. |
|---|
| Pathway |
PATH: ec00290 Valine, leucine and isoleucine biosynthesis
PATH: ec01065 Biosynthesis of alkaloids derived from histidine and
purine
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00052 3-isopropylmalate dehydrogenase |
|---|
| Genes |
ATH: AT1G31180 AT1G80560
POP: POPTR_1067569
RCU: RCOM_0011000
VVI: 100259968(GSVIVT00026591001)
OSA: 4333613(Os03g0655700)
SBI: SORBI_06g033720(SORBIDRAFT_06g033720)
ZMA: 100283376 100284589(cl362_2b)
PPP: PHYPADRAFT_115152
CRE: CHLREDRAFT_195906(LEU3b|LEU3a)
OLU: OSTLU_29616
CME: CMM229C
SCE: YCL018W(LEU2)
AGO: AGOS_AAL012C
KLA: KLLA0D04906g
LTH: KLTH0H12188g
DHA: DEHA0G11946g
PIC: PICST_68561(LEU2)
PPA: PAS_chr3_0039
VPO: Kpol_1048p63
LEL: LELG_05559
ZRO: ZYRO0E04796g
CAL: CaO19_7080(CaJ7_0053)
CTP: CTRG_04924
CDU: CD36_70610(LEU2)
CGR: CAGL0H03795g
SPO: SPBC1A4.02c(leu1)
NCR: NCU06232
PAN: PODANSg5277
MGR: MGG_05223 MGG_09813
FGR: FG06675.1 FG10671.1
ANI: AN0912.2
AFM: AFUA_1G15780 AFUA_6G13590
AOR: AO090005001122
ANG: An01g14130(leu2A)
AFV: AFLA_009040 AFLA_083640
PCS: Pc16g13350 Pc22g00840
NFI: NFIA_009550 NFIA_059550
CIM: CIMG_03106 CIMG_08476
URE: UREG_02552 UREG_02851
SSL: SS1G_07102
BFU: BC1G_14880
CNE: CNA04310
CNB: CNBA4140
LBC: LACBIDRAFT_231016
MPR: MPER_02541
UMA: UM01245.1
MGL: MGL_0905
PTI: PHATRDRAFT_20934(IPMDH)
TPS: THAPSDRAFT_268875
ECO: b0073(leuB)
ECJ: JW5807(leuB)
EBW: BWG_0069(leuB)
ECE: Z0082(leuB)
ECS: ECs0077
ECF: ECH74115_0080(leuB)
ETW: ECSP_0077(leuB)
ECG: E2348C_0078(leuB)
ECC: c0090(leuB)
ECI: UTI89_C0080(leuB)
ECP: ECP_0075
ECV: APECO1_1910(leuB)
ECW: EcE24377A_0076(leuB)
ECX: EcHS_A0078(leuB)
ECM: EcSMS35_0078(leuB)
ECY: ECSE_0073
ECL: EcolC_3584
ECK: EC55989_0071(leuB)
ECQ: ECED1_0073(leuB)
ECR: ECIAI1_0074(leuB)
ECT: ECIAI39_0078(leuB)
ECZ: ECS88_0078(leuB)
EUM: ECUMN_0075(leuB)
ELF: LF82_1179(leuB)
EBL: B21_00074(leuB)
EBD: ECBD_3543
EBR: ECB_00075(leuB)
EOH: ECO103_0075(leuB)
EOI: ECO111_0076(leuB)
EOJ: ECO26_0076(leuB)
EFE: EFER_0095(leuB)
STY: STY0131(leuB)
STT: t0116(leuB)
SPT: SPA0114(leuB)
SEK: SSPA0110
SPQ: SPAB_00142
SEI: SPC_0121(leuB)
SEC: SC0108(leuB)
SEH: SeHA_C0123(leuB)
SEE: SNSL254_A0124(leuB)
SEW: SeSA_A0128(leuB)
SEA: SeAg_B0128(leuB)
SED: SeD_A0121(leuB)
SEG: SG0114(leuB)
SET: SEN0113(leuB)
SES: SARI_02890
STM: STM0112(leuB)
YPE: YPO0532(leuB)
YPK: y3646(leuB)
YPM: YP_3650(leuB2)
YPA: YPA_3565
YPN: YPN_0402
YPG: YpAngola_A2937(leuB)
YPP: YPDSF_3107
YPS: YPTB0671(leuB)
YPI: YpsIP31758_3406(leuB)
YPY: YPK_3536
YPB: YPTS_0697
YEN: YE0653(leuB)
SFL: SF0068(leuB)
SFX: S0070(leuB)
SFV: SFV_0065(leuB)
SSN: SSON_0080(leuB)
SBO: SBO_0060(leuB)
SBC: SbBS512_E0067(leuB)
SDY: SDY_0100(leuB)
ECA: ECA3832(leuB)
PCT: PC1_3608
PWA: Pecwa_3796
ETA: ETA_07410(leuB)
PLU: plu3674(leuB)
PAY: PAU_01096(leuB)
BUC: BUpL05(leuB)
BAB: bbp496(leuB)
BCC: pLeuBCc_003(leuB)
SGL: SG0436
ENT: Ent638_0621
ESA: ESA_03265
CTU: Ctu_07060(leuB)
KPN: KPN_00079(leuB)
KPE: KPK_4663(leuB)
KPU: KP1_0895(leuB)
CKO: CKO_03305
SPE: Spro_0744
PMR: PMI2085(leuB)
EIC: NT01EI_0719
ETR: ETAE_0620(leuB)
BFL: Bfl132(leuB)
BPN: BPEN_136(leuB)
DDA: Dd703_0631
DDC: Dd586_3548
DZE: Dd1591_0593
HIN: HI0987(leuB)
HIT: NTHI1161(leuB)
HIP: CGSHiEE_07030
HAP: HAPS_0030(leuB)
HSO: HS_0391(leuB)
HSM: HSM_0716
PMU: PM1961(leuB)
MSU: MS0598(leuB)
APL: APL_0432(leuB)
APJ: APJL_0458(leuB)
APA: APP7_0507
ASU: Asuc_1908
AAP: NT05HA_1565
XFA: XF2372
XFT: PD1397(leuB)
XFM: Xfasm12_1539
XFN: XfasM23_1483
XCC: XCC3328(leuB)
XCB: XC_0836
XCA: xccb100_0869(leuB)
XCV: XCV3584(leuB)
XAC: XAC3456(leuB)
XOO: XOO0940(leuB)
XOM: XOO_0860
XOP: PXO_02610(leuB)
SML: Smlt3921(leuB)
SMT: Smal_3336
VCH: VC2491
VCO: VC0395_A2066(leuB)
VCM: VCM66_2413(leuB)
VCJ: VCD_001865
VVU: VV1_0655
VVY: VV0486
VPA: VP0344
VHA: VIBHAR_00816
VSP: VS_0379
VEX: VEA_001657
VFI: VF_0294(leuB)
VFM: VFMJ11_0282(leuB)
VSA: VSAL_I0376(leuB)
PPR: PBPRA0418
PAE: PA3118(leuB)
PAU: PA14_23790(leuB)
PAP: PSPA7_2015(leuB)
PAG: PLES_19411(leuB)
PPU: PP_1988(leuB)
PPF: Pput_3771
PPG: PputGB1_1519
PPW: PputW619_1551
PST: PSPTO_2175(leuB)
PSB: Psyr_1985
PSP: PSPPH_1954(leuB) PSPPH_2159
PFL: PFL_2066(leuB)
PFO: Pfl01_1892
PFS: PFLU4193
PEN: PSEEN1652(leuB)
PMY: Pmen_2721
PSA: PST_1774(leuB)
CJA: CJA_1746(leuB)
AVN: Avin_34260(leuB)
PAR: Psyc_1410(leuB)
PCR: Pcryo_1571
PRW: PsycPRwf_1934
ACI: ACIAD0469(leuB)
ACB: A1S_0420
ABM: ABSDF3095(leuB)
ABY: ABAYE3357(leuB)
ABC: ACICU_00428
ABN: AB57_0497(leuB)
ABB: ABBFA_003116(leuB)
SON: SO_4235(leuB)
SDN: Sden_0335
SFR: Sfri_3819
SAZ: Sama_0336
SBL: Sbal_0387
SBM: Shew185_0386
SBN: Sbal195_0398
SBP: Sbal223_0412
SLO: Shew_3471
SPC: Sputcn32_0472
SSE: Ssed_0394
SPL: Spea_3827
SHE: Shewmr4_3587
SHM: Shewmr7_0369
SHN: Shewana3_3760
SHW: Sputw3181_0375
SHL: Shal_0439
SWD: Swoo_4549
SWP: swp_2214
CPS: CPS_4209(leuB)
PHA: PSHAa2893(leuB)
PAT: Patl_3269
SDE: Sde_2084
MAQ: Maqu_1563 Maqu_2209
AMC: MADE_03086
PIN: Ping_2229
TTU: TERTU_2500(leuB)
MCA: MCA2063(leuB)
FTL: FTL_1887
FTN: FTN_0059(leuB)
FPH: Fphi_0772
TCX: Tcr_0797
NOC: Noc_1014
AEH: Mlg_0489 Mlg_1230 Mlg_2362
HHA: Hhal_0829 Hhal_1810
TGR: Tgr7_1247
HNA: Hneap_1716
HCH: HCH_02430(leuB)
CSA: Csal_2451
ABO: ABO_1467(leuB)
MMW: Mmwyl1_2093
AHA: AHA_0881(leuB)
ASA: ASA_3410(leuB)
TAU: Tola_0681
AFE: Lferr_1732
AFR: AFE_2075(leuB)
CRP: CRP_082
RMA: Rmag_0099
VOK: COSY_0103(leuB)
KKO: Kkor_0977
NMA: NMA1456(leuB)
NME: NMB1031(leuB)
NMC: NMC1182(leuB)
NMN: NMCC_1164(leuB)
NMI: NMO_1097(leuB)
NGO: NGO0674
NGK: NGK_1232
CVI: CV_2778(leuB)
LHK: LHK_01242(leuB)
RSO: RSc1988(leuB1) RSp0329(leuB2)
RPI: Rpic_2143
RPF: Rpic12D_1819
REU: Reut_A2311
REH: H16_A2133(leuB2) H16_A2619(leuB3)
RME: Rmet_2472
CTI: RALTA_A2118(leuB)
BMA: BMAA1726(leuB)
BMV: BMASAVP1_1643(leuB)
BML: BMA10229_1852(leuB)
BMN: BMA10247_A0523(leuB)
BPS: BPSS1705(leuB)
BPM: BURPS1710b_A0775(leuB)
BPL: BURPS1106A_A2313(leuB)
BPD: BURPS668_A2451(leuB)
BTE: BTH_II0674(leuB)
BVI: Bcep1808_4457
BUR: Bcep18194_B2131
BCN: Bcen_4415
BCH: Bcen2424_3952
BCM: Bcenmc03_3576
BCJ: BCAM0985(leuB)
BAM: Bamb_3343
BAC: BamMC406_3847
BMU: Bmul_4627
BMJ: BMULJ_03884(leuB)
BXE: Bxe_B2887
BPH: Bphy_4369
BPY: Bphyt_6847
BGL: bglu_2g08360
PNU: Pnuc_0767
PNE: Pnec_1054
BPE: BP1483(leuB)
BPA: BPP1944(leuB)
BBR: BB1014(leuB) BB2132(leuB)
BPT: Bpet3035(leuB)
BAV: BAV2268(leuB)
RFR: Rfer_1793
POL: Bpro_3610
PNA: Pnap_3041
AAV: Aave_1221
AJS: Ajs_3233
VEI: Veis_1047 Veis_1349
DAC: Daci_5238
DIA: Dtpsy_2586
VAP: Vapar_1420 Vapar_6279
CTT: CtCNB1_1005
MPT: Mpe_A2162
HAR: HEAR1217(leuB)
MMS: mma_2169(leuB)
LCH: Lcho_1677
NEU: NE0688(leuB)
NET: Neut_1147
NMU: Nmul_A1918
EBA: ebA4760(leuB)
AZO: azo1041(leuB)
DAR: Daro_0864 Daro_3775
TBD: Tbd_1920
MFA: Mfla_1703
MMB: Mmol_0974
MEI: Msip34_1551
APP: CAP2UW1_0184 CAP2UW1_1223
HHE: HH1134(leuB)
WSU: WS1813
TDN: Suden_1101
CJE: Cj1718c(leuB)
CJR: CJE1888(leuB)
CJJ: CJJ81176_0016(leuB)
CJU: C8J_1624(leuB)
CJD: JJD26997_2095(leuB)
CFF: CFF8240_1020(leuB)
CCV: CCV52592_1365(leuB)
CHA: CHAB381_1264(leuB)
CCO: CCC13826_0036(leuB)
ABU: Abu_1013(leuB)
SDL: Sdel_1516
NIS: NIS_0727(leuB)
SUN: SUN_1705(leuB)
NAM: NAMH_1248(leuB)
GSU: GSU2879(leuB)
GME: Gmet_0602
GUR: Gura_1045
GLO: Glov_0348
GBM: Gbem_0908
GEO: Geob_3653
GEM: GM21_3353
PCA: Pcar_1904(leuB)
PPD: Ppro_0045
DVU: DVU2985(leuB)
DVL: Dvul_0387
DVM: DvMF_1794
DDE: Dde_3222
DDS: Ddes_0509
DMA: DMR_16010(leuB)
DSA: Desal_1585
DBA: Dbac_1740
DRT: Dret_1100
DPS: DP1284
DOL: Dole_2219
DAL: Dalk_1240
DAT: HRM2_04430(leuB)
ADE: Adeh_2070
ACP: A2cp1_1886
AFW: Anae109_1754
ANK: AnaeK_1807
MXA: MXAN_1283
SCL: sce3735(leuB1) sce8151(leuB3)
HOH: Hoch_6339
SAT: SYN_00088
SFU: Sfum_2989 Sfum_3031
PUB: SAR11_0250(leuB)
MLO: mll4399
MES: Meso_3381
PLA: Plav_1425
SME: SMc04405(leuB)
SMD: Smed_3178
ATU: Atu2791(leuB)
ATC: AGR_C_5067
ARA: Arad_4909(leuB)
AVI: Avi_4359(leuB)
RET: RHE_CH04093(leuB) RHE_PF00339(ypf00171)
REC: RHECIAT_CH0004383(leuB)
RLE: RL4707(leuB)
RLT: Rleg2_3900
RLG: Rleg_4224
RHI: NGR_c06160 NGR_c25920 NGR_c33180(leuB)
BME: BMEII0404
BMI: BMEA_B0869(leuB)
BMF: BAB2_0346
BMB: BruAb2_0342(leuB)
BMC: BAbS19_II03270
BMS: BRA0890(leuB)
BMT: BSUIS_B0882(leuB)
BOV: BOV_A0834(leuB)
BCS: BCAN_B0908(leuB)
BMR: BMI_II884(leuB)
OAN: Oant_3287
BJA: bll0414(leuB) bll0504(leuB) bll6321(leuB) blr2741 blr2781
BRA: BRADO0353(leuB) BRADO2458
BBT: BBta_0340(leuB) BBta_2804
RPA: RPA0227(leuB)
RPB: RPB_0335
RPC: RPC_0240
RPD: RPD_0490
RPE: RPE_0480
RPT: Rpal_0226
NWI: Nwi_2795
NHA: Nham_3595
OCA: OCAR_4283(leuB)
XAU: Xaut_2589
AZC: AZC_0304
MEX: Mext_2524
MEA: Mex_1p2491(leuB)
MDI: METDI3254(leuB)
MRD: Mrad2831_2669
MET: M446_6646
MPO: Mpop_2452
MCH: Mchl_2747
MNO: Mnod_2259 Mnod_7390
BID: Bind_1182
MSL: Msil_3510
CCR: CC_0193
CCS: CCNA_00193(leuB)
CAK: Caul_0213
PZU: PHZ_c0104(leuB)
SIL: SPO0210(leuB)
SIT: TM1040_3762
RSP: RSP_0859(leuB)
RSH: Rsph17029_2518
RSQ: Rsph17025_0162
RSK: RSKD131_2230
JAN: Jann_0128
RDE: RD1_0228(leuB) RD1_3789(leuB)
PDE: Pden_0440
DSH: Dshi_0081(imdH) Dshi_3393(leuB)
MMR: Mmar10_0283
HNE: HNE_0056(leuB)
HBA: Hbal_2302
ZMO: ZMO0677
ZMN: Za10_0589
NAR: Saro_2662
SAL: Sala_1085
SWI: Swit_4494
ELI: ELI_08335
GOX: GOX0191
GBE: GbCGDNIH1_1678
ACR: Acry_1270 Acry_2147
GDI: GDI_3085(leuB)
GDJ: Gdia_3282
APT: APA01_17110
RRU: Rru_A1191
RCE: RC1_3962(leuB)
MAG: amb4069
MGM: Mmc1_1781
BSU: BSU28270(leuB)
BHA: BH3057(leuB)
BAN: BA1421(leuB)
BAR: GBAA1421(leuB)
BAA: BA_1941
BAT: BAS1312
BAH: BAMEG_3174(leuB)
BAI: BAA_1488(leuB)
BCE: BC1401
BCA: BCE_1521(leuB)
BCZ: BCZK1286(leuB)
BCR: BCAH187_A1560(leuB)
BCB: BCB4264_A1454(leuB)
BCU: BCAH820_1492(leuB)
BCG: BCG9842_B3890(leuB)
BCQ: BCQ_1474(leuB)
BCX: BCA_1456(leuB)
BCY: Bcer98_1124
BTK: BT9727_1285(leuB)
BTL: BALH_1256(leuB)
BWE: BcerKBAB4_1323
BLI: BL00612(leuB)
BLD: BLi02957(leuB)
BCL: ABC0628 ABC2641(leuB)
BAY: RBAM_025330(leuB)
BPU: BPUM_2468(leuB)
OIH: OB2619(leuB)
GKA: GK2657
GTN: GTNG_2586
GWC: GWCH70_2592
GYM: GYMC10_5136
GYC: GYMC61_0860
AFL: Aflv_0595(leuB)
SAU: SA1863(leuB)
SAV: SAV2058(leuB)
SAW: SAHV_2043(leuB)
SAM: MW1982(leuB)
SAR: SAR2145(leuB)
SAS: SAS1963
SAC: SACOL2047(leuB)
SAB: SAB1943(leuB)
SAA: SAUSA300_2011(leuB)
SAX: USA300HOU_2053(leuB)
SAO: SAOUHSC_02286
SAJ: SaurJH9_2095
SAH: SaurJH1_2132
SAE: NWMN_1964(leuB)
SAD: SAAV_2106(leuB)
SEP: SE1659
SER: SERP1670(leuB)
SHA: SH0975(leuB)
SSP: SSP0820
SCA: Sca_1564(leuB)
LMO: lmo1988(leuB)
LMF: LMOf2365_2011(leuB)
LMH: LMHCC_0572(leuB)
LMC: Lm4b_02000(leuB)
LIN: lin2095
LWE: lwe2007(leuB)
LSP: Bsph_3385
BBE: BBR47_16220(leuB)
PJD: Pjdr2_1307
AAC: Aaci_2226
LLA: L0074(leuB)
LLK: LLKF_1261(leuB)
LLC: LACR_1320
SPD: SPD_1115(leuB)
SPR: spr1135(leuB)
SPW: SPCG_1046
SPX: SPG_1149
SNE: SPN23F_11520(leuB)
SPV: SPH_1373(leuB)
SNM: SP70585_1320(leuB)
SJJ: SPJ_1171(leuB)
SPP: SPP_1295(leuB)
SNT: SPT_0971(leuB)
SMU: SMU.1383(leuB)
STC: str1202(leuB)
STL: stu1202(leuB)
STE: STER_1170
SSA: SSA_0977(leuB)
SSU: SSU05_1948
SSV: SSU98_1953
SSB: SSUBM407_1810(leuB)
SSI: SSU1740(leuB)
SSS: SSUSC84_1762(leuB)
SGO: SGO_0907(leuB)
LFE: LAF_0965
LME: LEUM_2031
LCI: LCK_01491(leuB)
CAC: CAC3171(leuB)
CTH: Cthe_2209
CDF: CD0992(leuB)
CDC: CD196_0865(leuB)
CDL: CDR20291_0845(leuB)
CBK: CLL_A0324(leuB)
CBT: CLH_0305(leuB)
CBE: Cbei_0216
CKL: CKL_2157(leuB)
CKR: CKR_1892
CPY: Cphy_3358
CCE: Ccel_0128
AMT: Amet_3455
STH: STH3035
SWO: Swol_2140
VPR: Vpar_0097
ATE: Athe_2099
DSY: DSY1371 DSY3587
DHD: Dhaf_2487
DRM: Dred_0288
PTH: PTH_0534(leuB)
DAU: Daud_1279
HMO: HM1_1518(leuB)
EEL: EUBELI_00761
ERE: EUBREC_1878
TTE: TTE0019(leuB)
TEX: Teth514_0017
TPD: Teth39_0018
CHY: CHY_0524(leuB)
MTA: Moth_2252
ADG: Adeg_1962
CSC: Csac_1333
HOR: Hore_10890
MTU: Rv2995c(leuB)
MTC: MT3073(leuB)
MRA: MRA_3024(leuB)
MTF: TBFG_13010
MTB: TBMG_00975(TBMG_00975.1)
MBO: Mb3019c(leuB)
MBB: BCG_3016c(leuB)
MBT: JTY_3011(leuB)
MLE: ML1691(leuB)
MLB: MLBr_01691(leuB)
MPA: MAP3032c(leuB)
MAV: MAV_3845(leuB)
MSM: MSMEG_2379(leuB) MSMEG_3285
MUL: MUL_1953(leuB)
MVA: Mvan_2129
MGI: Mflv_4233
MAB: MAB_3303c
MMC: Mmcs_1911 Mmcs_2572
MKM: Mkms_1957 Mkms_2617
MJL: Mjls_1891 Mjls_2611
MMI: MMAR_1716(leuB)
CGL: NCgl1237(cgl1286)
CGB: cg1453(leuB)
CGT: cgR_1364
CEF: CE1383(leuB)
CDI: DIP1105(leuB)
CJK: jk1288(leuB)
CUR: cur_0764 cur_1141
CAR: cauri_1136(leuB)
CKP: ckrop_1234
NFA: nfa18790 nfa42200(leuB)
RHA: RHA1_ro00322(leuB1) RHA1_ro00984(leuB2) RHA1_ro04803
RHA1_ro06490(leuB3) RHA1_ro08803
RER: RER_24010(leuB) RER_33170
ROP: ROP_07140 ROP_65430(leuB)
GBR: Gbro_2885 Gbro_3224
SCO: SCO5522(leuB)
SMA: SAV_2718(leuB)
SGR: SGR_1983
LXX: Lxx13130(leuB)
CMI: CMM_1104(leuB)
CMS: CMS_1424(leuB)
ART: Arth_2530
AAU: AAur_2498(leuB)
ACH: Achl_2268
RSA: RSal33209_1060
KRH: KRH_10250(leuB)
MLU: Mlut_08590
BCV: Bcav_1417
BFA: Bfae_18770
JDE: Jden_1704
XCE: Xcel_2383
NCA: Noca_3368
TFU: Tfu_0615
TCU: Tcur_3544
SRO: Sros_8042
FRA: Francci3_3632
FRE: Franean1_1098
FAL: FRAAL5843(leuB)
ACE: Acel_0710
NML: Namu_1472
KRA: Krad_1352 Krad_2488
SEN: SACE_3196(leuB) SACE_3495(leuB1) SACE_4608 SACE_6154(leuB)
SVI: Svir_08950 Svir_14420
AMI: Amir_6014
STP: Strop_1239
SAQ: Sare_1129
CAI: Caci_7787
BLO: BL1218(leuB)
BLJ: BLD_0981(leuB)
BLN: Blon_2070
BAD: BAD_1340(leuB)
BLA: BLA_0567(leuB)
BLC: Balac_1362
BLT: Balat_1362
RXY: Rxyl_3130
AFO: Afer_1536
CCU: Ccur_04390
ELE: Elen_0585
LIL: LA2152(leuB)
LIC: LIC11768(leuB)
LBJ: LBJ_1863(leuB-1)
LBL: LBL_1421(leuB-1)
LBI: LEPBI_I2317(leuB)
LBF: LBF_2251(leuB-1)
BHY: BHWA1_01041(leuB)
ABA: Acid345_2917 Acid345_2964
ACA: ACP_3470(leuB)
SUS: Acid_1530 Acid_4068
BTH: BT_1857
BFR: BF3444
BFS: BF3263(leuB)
BVU: BVU_2008
PDI: BDI_2059
APS: CFPG_565
SRU: SRU_2148(leuB)
RMR: Rmar_0739
CHU: CHU_3744(leuB)
DFE: Dfer_3671
CPI: Cpin_1985
PHE: Phep_3428
GFO: GFO_2098(leuB)
FJO: Fjoh_1304 Fjoh_2864
RBI: RB2501_15804
SMG: SMGWSS_040(leuB)
SMS: SMDSEM_044(leuB)
BBL: BLBBGE_070(leuD)
BPI: BPLAN_564(leuB)
FSU: Fisuc_2644
LBA: Lebu_1710 Lebu_1719
STR: Sterm_0114
OTE: Oter_3663
MIN: Minf_1566(leuB)
AMU: Amuc_0785
RBA: RB12597(leuB) RB3767(leuB)
RSD: TGRD_453
TAI: Taci_1612
SYN: slr1517(leuB)
SYW: SYNW0784(leuB)
SYC: syc2490_c(leuB)
SYF: Synpcc7942_1505
SYD: Syncc9605_1865
SYE: Syncc9902_0788
SYG: sync_1712(leuB)
SYR: SynRCC307_0997(leuB)
SYX: SynWH7803_1152(leuB)
SYP: SYNPCC7002_A2354(leuB)
CYA: CYA_1798(leuB)
CYB: CYB_1631(leuB)
TEL: tlr1600(leuB)
MAR: MAE_00210(leuB)
CYT: cce_3617(leuB)
CYP: PCC8801_0340
CYC: PCC7424_4657
CYN: Cyan7425_2577
CYH: Cyan8802_0347
GVI: gvip479(leuB)
ANA: alr1313(leuB)
NPU: Npun_R2802
AVA: Ava_2987
PMA: Pro0862(leuB)
PMM: PMM0786(leuB)
PMT: PMT0531(leuB)
PMN: PMN2A_0194
PMI: PMT9312_0794
PMB: A9601_08501(leuB)
PMC: P9515_07951(leuB)
PMF: P9303_17341(leuB)
PMG: P9301_08471(leuB)
PMH: P9215_08811(leuB)
PMJ: P9211_09751(leuB)
PME: NATL1_08261(leuB)
TER: Tery_4403
AMR: AM1_0898(leuB)
CTE: CT0615(leuB)
CPC: Cpar_0631
CCH: Cag_1901
CPH: Cpha266_0850
CPB: Cphamn1_1720
CLI: Clim_0738
PVI: Cvib_1173
PLT: Plut_0603
PPH: Ppha_2173
PAA: Paes_0740
CTS: Ctha_1628
DET: DET0826(leuB)
DEH: cbdb_A804(leuB)
DEB: DehaBAV1_0745
DEV: DhcVS_730(leuB)
RRS: RoseRS_1057 RoseRS_1958
RCA: Rcas_1546 Rcas_3471
CAU: Caur_0041 Caur_0331
CAG: Cagg_0588 Cagg_3600
CHL: Chy400_0047 Chy400_0356
HAU: Haur_3304 Haur_4439
TRO: trd_1693(leuB)
STI: Sthe_0766
DRA: DR_1785
DGE: Dgeo_1033 Dgeo_1458
DDR: Deide_12390(leuB)
TTH: TTC0867
TTJ: TTHA1230
AAE: aq_244(leuB)
HYA: HY04AAS1_1260
SUL: SYO3AOP1_0648
SAF: SULAZ_0271(leuB)
PMX: PERMA_0387(leuB)
TMA: TM0556
TPT: Tpet_0364
TRQ: TRQ2_0381
TNA: CTN_0112
TNP: Tnap_0336
PMO: Pmob_1586
DTH: DICTH_1066(leuB)
DTU: Dtur_1193
TYE: THEYE_A0114
TTR: Tter_0192
MJA: MJ0720
MFE: Mefer_0957 Mefer_1072
MVU: Metvu_0636
MMP: MMP0539(leuB)
MMQ: MmarC5_1068
MMX: MmarC6_0353
MMZ: MmarC7_1558
MAE: Maeo_1416
MVN: Mevan_1693
MAC: MA0201(leuB) MA3748(leuB)
MBA: Mbar_A0248 Mbar_A1339
MMA: MM_1489
MBU: Mbur_1632
MTP: Mthe_0025 Mthe_0855
MHU: Mhun_1797 Mhun_2363
MLA: Mlab_0235 Mlab_0609
MEM: Memar_0637 Memar_1947
MBN: Mboo_0602 Mboo_2077
MPL: Mpal_0187 Mpal_2146
MPD: MCP_1963(aksF) MCP_2993(leuB)
MTH: MTH1388 MTH184
MST: Msp_1484(leuB)
MSI: Msm_0373 Msm_1298
MKA: MK0782(leuB_1) MK1215(leuB_2)
AFU: AF0628(leuB)
HMA: rrnAC0340(ipmD)
HWA: HQ2707A(leuB)
NPH: NP2190A(leuB)
HLA: Hlac_0870
HUT: Huta_0651
HMU: Hmuk_2659
PTO: PTO0910
PHO: PH1722
PAB: PAB0289(leuB-2) PAB2424(leuB-1)
PFU: PF0940
TKO: TK0280
RCI: RCIX2644(leuB-2) RCIX993(leuB-1)
IHO: Igni_0982
SSO: SSO0723(leuB)
STO: ST0433
SAI: Saci_0600(leuB)
SIS: LS215_1512
SIA: M1425_1417
SIM: M1627_1467
SID: M164_1411
SIY: YG5714_1412
SIN: YN1551_1431
MSE: Msed_0088
PAI: PAE1995
PIS: Pisl_1815
PCL: Pcal_1605
PAS: Pars_2064
CMA: Cmaq_1172
TNE: Tneu_0833
NMR: Nmar_1069
KCR: Kcr_0190
 |
|---|
| Structures |
PDB: 1A05 1DPZ 1DR0 1DR8 1G2U 1GC8 1GC9 1HEX 1IDM 1IPD
1OSI 1OSJ 1V53 1V5B 1VLC 1W0D 1WPW 1XAA 1XAB 1XAC
1XAD 2AYQ 2G4O 2ZTW |
|---|
Reference
Authors
Title
Journal
|
1 [PMID:14087358]
BURNS RO, UMBARGER HE, GROSS SR
THE BIOSYNTHESIS OF LEUCINE. III. THE CONVERSION OF
ALPHA-HYDROXY-BETA-CARBOXYISOCAPROATE TO ALPHA-KETOISOCAPROATE.
Biochemistry. 2 (1963) 1053-8. |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:4889950]
Parsons SJ, Burns RO.
Purification and properties of beta-isopropylmalate dehydrogenase.
J. Biol. Chem. 244 (1969) 996-1003.
Salmonella typhimurium [GN:stm] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:10683439]
Nemeth A, Svingor A, Pocsik M, Dobo J, Magyar C, Szilagyi A, Gal P,
Zavodszky P.
Mirror image mutations reveal the significance of an intersubunit
ion cluster in the stability of 3-isopropylmalate dehydrogenase.
FEBS. Lett. 468 (2000) 48-52.
Escherichia coli [GN:eco], Thermus thermophilus [GN:ttj] |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:14269331]
CALVO JM, STEVENS CM, KALYANPUR MG, UMBARGER HE.
THE ABSOLUTE CONFIGURATION OF ALPHA-HYDROXY-BETA-CARBOXYISOCAPROIC
ACID (3-ISOPROPYLMALIC ACID), AN INTERMEDIATE IN LEUCINE
BIOSYNTHESIS.
Biochemistry. 19 (1964) 2024-7.
Neurospora crassa [GN:ncr] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.1.1.85
IUBMB Enzyme Nomenclature: 1.1.1.85
ExPASy - ENZYME nomenclature database: 1.1.1.85
BRENDA, the Enzyme Database: 1.1.1.85
CAS: 9030-97-1 |
|---|
