| Entry |
|
|---|
| Name |
homoisocitrate dehydrogenase;
2-hydroxy-3-carboxyadipate dehydrogenase;
3-carboxy-2-hydroxyadipate dehydrogenase;
homoisocitric dehydrogenase;
(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD+ oxidoreductase
(decarboxylating);
3-carboxy-2-hydroxyadipate:NAD+ oxidoreductase (decarboxylating);
HICDH |
|---|
| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase
(decarboxylating) |
|---|
| Reaction(IUBMB) |
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD+ = 2-oxoadipate +
CO2 + NADH + H+ [RN:R01934] |
|---|
| Reaction(KEGG) |
R01934;
(other) R01936 R04862
 |
|---|
| Substrate |
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate [CPD:C05662];
NAD+ [CPD:C00003] |
|---|
| Product |
2-oxoadipate [CPD:C00322];
CO2 [CPD:C00011];
NADH [CPD:C00004];
H+ [CPD:C00080] |
|---|
| Comment |
Forms part of the lysine biosynthesis pathway in fungi [3]. |
|---|
| Pathway |
PATH: ec00300 Lysine biosynthesis
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K05824 homoisocitrate dehydrogenase |
|---|
| Genes |
SCE: YIL094C(LYS12)
AGO: AGOS_ADL214C
KLA: KLLA0E08305g
DHA: DEHA0C18106g
PIC: PICST_50442(LYS12)
CAL: CaO19.10060(LYS12)
CGR: CAGL0G02585g
SPO: SPAC31G5.04
NCR: NCU02954
MGR: MGG_01566
ANI: AN5206.2
AFM: AFUA_6G07390
AOR: AO090005001561
ANG: An15g02490
CNE: CND03850
UMA: UM04873.1
DRA: DR_1674
TTH: TTC1012
TTJ: TTHA1378
 |
|---|
| Structures |
PDB: 1X0L |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:4284830]
Strassman M, Ceci LN.
Enzymatic formation of alpha-ketoadipic acid from homoisocitric
acid.
J. Biol. Chem. 240 (1965) 4357-61.
Torulopsis utilis |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:4395693]
Rowley B, Tucci AF.
Homoisocitric dehydrogenase from yeast.
Arch. Biochem. Biophys. 141 (1970) 499-510.
Saccharomyces cerevisiae [GN:sce] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:10714900]
Zabriskie TM, Jackson MD.
Lysine biosynthesis and metabolism in fungi.
Nat. Prod. Rep. 17 (2000) 85-97.
Saccharomyces cerevisiae [GN:sce] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.1.1.87
IUBMB Enzyme Nomenclature: 1.1.1.87
ExPASy - ENZYME nomenclature database: 1.1.1.87
BRENDA, the Enzyme Database: 1.1.1.87
CAS: 9067-90-7 |
|---|
