KEGG   ENZYME: 1.1.1.87Help
Entry
EC 1.1.1.87                 Enzyme                                 

Name
homoisocitrate dehydrogenase;
2-hydroxy-3-carboxyadipate dehydrogenase;
3-carboxy-2-hydroxyadipate dehydrogenase;
homoisocitric dehydrogenase;
(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD+ oxidoreductase (decarboxylating);
3-carboxy-2-hydroxyadipate:NAD+ oxidoreductase (decarboxylating);
HICDH
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating)
Reaction(IUBMB)
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD+ = 2-oxoadipate + CO2 + NADH + H+ [RN:R01934]
Reaction(KEGG)
R01934;
(other) R01936 R04862
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Substrate
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate [CPD:C05662];
NAD+ [CPD:C00003]
Product
2-oxoadipate [CPD:C00322];
CO2 [CPD:C00011];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Forms part of the lysine biosynthesis pathway in fungi [3].
History
EC 1.1.1.87 created 1972 (EC 1.1.1.155 created 1976, incorporated 2004)
Pathway
Lysine biosynthesis
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K05824  
homoisocitrate dehydrogenase
K10978  
methanogen homoisocitrate dehydrogenase
Genes
SCE: 
YIL094C(LYS12)
AGO: 
ERC: 
KLA: 
LTH: 
PPA: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0B06250(NCAS0B06250)
NDI: 
NDAI_0B03550(NDAI0B03550)
TPF: 
TPHA_0C03410(TPHA0C03410)
TBL: 
TBLA_0B05940(TBLA0B05940)
TDL: 
TDEL_0G02180(TDEL0G02180)
KAF: 
KAFR_0J01360(KAFR0J01360)
DHA: 
PIC: 
PGU: 
SPAA: 
LEL: 
CAL: 
CaO19.10060(LYS12) CaO19.2525(LYS12)
CTP: 
COT: 
CDU: 
CTEN: 
YLI: 
NCR: 
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
TMN: 
FGR: 
TRE: 
MAW: 
MAJ: 
CMT: 
VAL: 
ELA: 
SSL: 
BFU: 
MBE: 
ANI: 
AFM: 
AOR: 
AOR_1_2718174(AO090005001561)
ANG: 
ANI_1_398134(An15g02490)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
PBL: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
BCOM: 
NPA: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
TMS: 
DSQ: 
SHS: 
PCO: 
PSQ: 
ADL: 
FME: 
GTR: 
LBC: 
MRR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT113649(AGABI1DRAFT_113649)
ABV: 
AGABI2DRAFT191701(AGABI2DRAFT_191701)
CPUT: 
SLA: 
UMA: 
PFP: 
MGL: 
MLR: 
WSE: 
ACAN: 
NGR: 
PDR: 
PKC: 
PKB_4900(leub3)
RRS: 
RCA: 
CAU: 
CAG: 
CHL: 
HAU: 
ATM: 
CAP: 
DRA: 
DGE: 
DDR: 
DMR: 
DGO: 
DPD: 
TRA: 
TTH: 
TTJ: 
TTS: 
TTL: 
TSC: 
THC: 
TOS: 
MRB: 
MRE: 
MSV: 
OPR: 
MHD: 
MJA: 
MFE: 
MVU: 
MFS: 
MIF: 
MIG: 
MMP: 
MMP0880(aksF)
MMQ: 
MMX: 
MMZ: 
MMD: 
MAE: 
MVN: 
MVO: 
MOK: 
MAC: 
MA3748(leuB)
MBA: 
MMA: 
MMAZ: 
MMH: 
MEV: 
MZH: 
MPY: 
MHZ: 
MTP: 
MCJ: 
MCON_1920(aksF)
MHI: 
MHU: 
MLA: 
MEM: 
MPI: 
MBN: 
MFO: 
MPL: 
MPD: 
MCP_1963(aksF)
MEZ: 
Mtc_1557(aksF)
RCI: 
RCIX2644(leuB-2)
MTH: 
MMG: 
MST: 
MSI: 
MRU: 
mru_1033(aksF)
MEB: 
Abm4_0999(aksF)
MEL: 
MEW: 
METH: 
MBMB1_1404(leuB1)
MFV: 
MKA: 
MK1215(LeuB_2)
 » show all
Taxonomy
Reference
1  [PMID:4284830]
  Authors
Strassman M, Ceci LN.
  Title
Enzymatic formation of alpha-ketoadipic acid from homoisocitric acid.
  Journal
J. Biol. Chem. 240 (1965) 4357-61.
  Organism
Torulopsis utilis
Reference
2  [PMID:4395693]
  Authors
Rowley B, Tucci AF.
  Title
Homoisocitric dehydrogenase from yeast.
  Journal
Arch. Biochem. Biophys. 141 (1970) 499-510.
  Organism
Saccharomyces cerevisiae
  Sequence
[sce:YIL094C]
Reference
3  [PMID:10714900]
  Authors
Zabriskie TM, Jackson MD.
  Title
Lysine biosynthesis and metabolism in fungi.
  Journal
Nat. Prod. Rep. 17 (2000) 85-97.
  Organism
Saccharomyces cerevisiae
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9067-90-7

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