KEGG   ENZYME: 1.1.2.2Help
Entry
EC 1.1.2.2                  Enzyme                                 

Name
mannitol dehydrogenase (cytochrome);
polyol dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With a cytochrome as acceptor
BRITE hierarchy
Sysname
D-mannitol:cytochrome-c 2-oxidoreductase
Reaction(IUBMB)
D-mannitol + a ferricytochrome c = D-fructose + a ferrocytochrome c + 2 H+ [RN:R00865]
Reaction(KEGG)
R00865;
(other) R01892
Show
Substrate
D-mannitol [CPD:C00392];
ferricytochrome c [CPD:C00125]
Product
D-fructose [CPD:C00095];
ferrocytochrome c [CPD:C00126];
H+ [CPD:C00080]
Comment
The enzyme from the bacterium Gluconobacter oxydans acts on polyols with a D-lyxo configuration, such as D-mannitol and D-sorbitol, with preference towards the former.
History
EC 1.1.2.2 created 1961
Pathway
Pentose and glucuronate interconversions
Fructose and mannose metabolism
Reference
1  [PMID:13373782]
  Authors
ARCUS AC, EDSON NL.
  Title
Polyol dehydrogenases.  2.  The polyol dehydrogenases of Acetobacter suboxydans and Candida utilis.
  Journal
Biochem. J. 64 (1956) 385-94.
Reference
2
  Authors
Cho, N.C., Kim, K. and Jhon, D.Y.
  Title
Purification and characterization of polyol dehydrogenase from Gluconobacter melanogenus.
  Journal
Han'guk Saenghwa Hakhaochi 23 (1990) 172-178.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37250-78-5

DBGET integrated database retrieval system