| Entry |
|
|---|
| Name |
L-lactate dehydrogenase (cytochrome);
lactic acid dehydrogenase;
cytochrome b2 (flavin-free derivative of flavocytochrome b2);
flavocytochrome b2;
L-lactate cytochrome c reductase;
L(+)-lactate:cytochrome c oxidoreductase;
dehydrogenase, lactate (cytochrome);
L-lactate cytochrome c oxidoreductase;
lactate dehydrogenase (cytochrome);
lactic cytochrome c reductase |
|---|
| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With a cytochrome as acceptor
 |
|---|
| Sysname |
(S)-lactate:ferricytochrome-c 2-oxidoreductase |
|---|
| Reaction(IUBMB) |
(S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c +
2 H+ [RN:R00196] |
|---|
| Reaction(KEGG) |
R00196
 |
|---|
| Substrate |
(S)-lactate [CPD:C00186];
ferricytochrome c [CPD:C00125] |
|---|
| Product |
pyruvate [CPD:C00022];
ferrocytochrome c [CPD:C00126];
H+ [CPD:C00080] |
|---|
| Cofactor |
Heme [CPD:C00032];
FMN [CPD:C00061] |
|---|
| Comment |
Identical with cytochrome b2; a flavohemoprotein (FMN). |
|---|
| Pathway |
PATH: ec00620 Pyruvate metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00101 L-lactate dehydrogenase (cytochrome) |
|---|
| Genes |
SCE: YML054C(CYB2)
KLA: KLLA0D02640g
LTH: KLTH0C11770g
PIC: PICST_53263(CYB3)
PPA: PAS_chr4_0272
VPO: Kpol_1014p5
LEL: LELG_03556
ZRO: ZYRO0B13728g
CTP: CTRG_03633 CTRG_03635
CDU: CD36_12610
YLI: YALI0E21307g
SPO: SPAPB1A11.03
NCR: NCU08272
PAN: PODANSg7116
MGR: MGG_14264
FGR: FG01812.1 FG03984.1 FG05328.1
ANI: AN3901.2 AN4424.2
AFM: AFUA_1G07200 AFUA_4G03120 AFUA_4G07020
AOR: AO090011000188 AO090102000252
ANG: An04g08560 An14g02250
AFV: AFLA_003700 AFLA_112920
PCS: Pc12g14280 Pc21g12160 Pc22g18190
NFI: NFIA_030340 NFIA_109210
CIM: CIMG_04139 CIMG_08907
URE: UREG_02812 UREG_05576
SSL: SS1G_00686 SS1G_04795 SS1G_13096
BFU: BC1G_00542 BC1G_11840 BC1G_14059
CNE: CNH01230 CNL04570
CNB: CNBI2270 CNBL1170
LBC: LACBIDRAFT_230911 LACBIDRAFT_296363
MPR: MPER_05144 MPER_08668
UMA: UM04746.1
MGL: MGL_0614 MGL_4274
ECO: b3605(lldD)
ECJ: JW3580(lldD)
ECD: ECDH10B_3787(lldD)
EBW: BWG_3296(lldD)
ECE: Z5032(lldD)
ECS: ECs4483(lldD)
ECF: ECH74115_4978(lldD)
ETW: ECSP_4602(lldD)
ECG: E2348C_3854(lldD)
ECC: c4427(lldD)
ECI: UTI89_C4146(lldD)
ECP: ECP_3706(lldD)
ECV: APECO1_2850(lldD)
ECW: EcE24377A_4109(lldD)
ECX: EcHS_A3817(lldD)
ECM: EcSMS35_3942(lldD)
ECY: ECSE_3887(lldD)
ECL: EcolC_0103(lldD)
ECK: EC55989_4072(lldD)
ECQ: ECED1_4291(lldD)
ECR: ECIAI1_3778(lldD)
ECT: ECIAI39_4126(lldD)
ECZ: ECS88_4022(lldD)
EUM: ECUMN_4120(lldD)
ELF: LF82_1207(lldD)
EBL: B21_03414(lldD)
EBD: ECBD_0120
EBR: ECB_03463(lldD)
EOH: ECO103_4574(lldD)
EOI: ECO111_4430(lldD)
EOJ: ECO26_4992(lldD)
EFE: EFER_3599(lldD)
STY: STY4102(lldD)
STT: t3825(lldD)
SPT: SPA3546(lldD)
SEK: SSPA3309(lldD)
SPQ: SPAB_04590(lldD)
SEI: SPC_3776(lctD)
SEC: SC3618(lldD)
SEH: SeHA_C4018(lldD)
SEE: SNSL254_A3973(lldD)
SEW: SeSA_A3895(lldD)
SEA: SeAg_B3911(lldD)
SED: SeD_A4080(lldD)
SEG: SG3737(lldD)
SET: SEN3516(lldD)
SES: SARI_03948(lldD)
STM: STM3694(lldD)
YPE: YPO1569(lldD)
YPK: y2596(lldD)
YPM: YP_1457(lldD)
YPA: YPA_0864(lldD)
YPN: YPN_2411(lldD)
YPG: YpAngola_A1696(lldD)
YPP: YPDSF_1407(lldD)
YPS: YPTB1578(lldD)
YPI: YpsIP31758_2409(lldD)
YPY: YPK_2506(lldD)
YPB: YPTS_1692(lldD)
SFL: SF3644(lldD)
SFX: S4124(lldD)
SFV: SFV_3926(lldD)
SSN: SSON_3800(lldD)
SBO: SBO_3610(lldD)
SBC: SbBS512_E4031(lldD)
SDY: SDY_4038(lldD)
ECA: ECA0119(lldD)
PCT: PC1_4132
PWA: Pecwa_4413
PLU: plu1106
ENT: Ent638_0130(lldD)
ESA: ESA_03841(lldD)
CTU: Ctu_01630(lldD)
KPN: KPN_03949(lldD)
KPE: KPK_0146(lldD)
KPU: KP1_5298(lldD)
CKO: CKO_05061(lldD)
SPE: Spro_3855(lldD)
HIN: HI1739.1(lldD)
HIT: NTHI2049(lldD)
HIP: CGSHiEE_03345(lldD)
HIQ: CGSHiGG_02435(lldD)
HDU: HD0084(lldD)
PMU: PM0288(lldD)
APL: APL_1849(lldD)
APJ: APJL_1891(lldD)
APA: APP7_1939(lldD)
AAP: NT05HA_2024
AAT: D11S_1786
XCC: XCC0106(lldD)
XCB: XC_0110(lldD)
XCA: xccb100_0117(lldD)
XCV: XCV0110(lldD)
XAC: XAC0133(lldD)
XOO: XOO0022(lldD)
XOM: XOO_0022(lldD)
XOP: PXO_03463(lldD)
SML: Smlt2908(lctD)
SMT: Smal_2360
VCH: VCA0984(lldD)
VCO: VC0395_0254(lldD)
VCM: VCM66_A0943(lldD)
VCJ: VCD_000354
VPA: VPA1499(lldD)
VSP: VS_II1398(lldD)
VEX: VEA_001223
PAE: PA2382(lldA) PA4771(lldD)
PAU: PA14_33860(lldA) PA14_63090(lldD)
PAP: PSPA7_2879(lldA) PSPA7_5491(lldD)
PAG: PLES_29201(lldA) PLES_51561(lldD)
PPU: PP_4736(lldD)
PPF: Pput_4602(lldD)
PPG: PputGB1_4737(lldD)
PPW: PputW619_0695(lldD)
PSB: Psyr_0908(lldD)
PFS: PFLU3611 PFLU4305
PEN: PSEEN0767(lldD)
PMY: Pmen_3635(lldD)
CJA: CJA_1131(lldD)
PAR: Psyc_1654(lldA)
PCR: Pcryo_1889
PRW: PsycPRwf_1682
ACI: ACIAD0108(lldD)
ACB: A1S_0069
ABM: ABSDF0087(lldD)
ABY: ABAYE3797(lldD)
ABC: ACICU_00095(lldD)
ABN: AB57_0118(lldD)
ABB: ABBFA_003443(lldD)
CPS: CPS_2083
MAQ: Maqu_2344
FTU: FTT_0303c(lldD1)
FTF: FTF0303c(lldD1)
FTW: FTW_1032 FTW_1782(lldD)
FTL: FTL_0214 FTL_0970
FTH: FTH_0209(lldD) FTH_0948(lldA)
FTA: FTA_0229 FTA_1022
FTM: FTM_1166(lldD) FTM_1549
FTN: FTN_0217 FTN_0991(lldD)
FPH: Fphi_0607 Fphi_1597
CSA: Csal_0404(lldD)
MMW: Mmwyl1_1831 Mmwyl1_3713
NMA: NMA1592
NME: NMB1377(lldD)
NMC: NMC1312(lldA)
NMN: NMCC_1290(lldA)
NMI: NMO_1217(lldA)
NGO: NGO0639
NGK: NGK_1275
REU: Reut_A1661 Reut_C6258
REH: H16_B0460(lldA) H16_B1817(lldD)
CTI: RALTA_A1662(lldD)
BMA: BMAA0374(lldD) BMAA1565
BMV: BMASAVP1_1563(lldD)
BML: BMA10229_1750(lldD) BMA10229_2038
BMN: BMA10247_A0415(lldD) BMA10247_A0717
BPS: BPSS1560(mdlB) BPSS2125(lldA)
BPM: BURPS1710b_A0604(mdlB) BURPS1710b_A1229(lldA)
BPL: BURPS1106A_A2112 BURPS1106A_A2872
BPD: BURPS668_A2199 BURPS668_A2580(lldD) BURPS668_A2990
BTE: BTH_II0813
BCM: Bcenmc03_5250
BCJ: BCAL1769(mdlB) BCAM2277
BMU: Bmul_1696 Bmul_5795
BMJ: BMULJ_01546(lldD) BMULJ_05727(lldD)
BXE: Bxe_A2428 Bxe_A3368 Bxe_B0136 Bxe_C0228
BPH: Bphy_3174 Bphy_5156 Bphy_6162
BPY: Bphyt_6402
BGL: bglu_1g22680 bglu_2g01320
PNU: Pnuc_1371
BPE: BP0484(lldD) BP1293(lldD) BP1669(lldA)
BPA: BPP2925(lldD) BPP4394(lldD)
BBR: BB1109(lldD) BB2895(lldD) BB4980(lldD)
BPT: Bpet0014 Bpet0279
BAV: BAV1883(lctD) BAV3401(lctD)
RFR: Rfer_2351
POL: Bpro_3678
PNA: Pnap_3154
AAV: Aave_1959 Aave_3519(lldD)
AJS: Ajs_3487
VEI: Veis_3178
DAC: Daci_0789 Daci_3346(lldD) Daci_5294 Daci_5798
DIA: Dtpsy_2651 Dtpsy_2810
VAP: Vapar_1331 Vapar_3912
CTT: CtCNB1_0943 CtCNB1_0948 CtCNB1_3085 CtCNB1_3675
MPT: Mpe_A0360 Mpe_A2829
HAR: HEAR1710(lldD)
MMS: mma_1588(lldD)
LCH: Lcho_3859
AZO: azo1016(lldA) azo2470(lldD)
TMZ: Tmz1t_0668
CCV: CCV52592_0468
PUB: SAR11_0280(ildD)
MLO: mll6909
MES: Meso_3045
PLA: Plav_0762
SME: SM_b20850(lldD3) SMc01712(lldD2) SMc01740(lldD1)
SMD: Smed_3514 Smed_4493 Smed_5475
ATU: Atu2318(lldA) Atu3871(lldA)
ATC: AGR_C_4216 AGR_L_1949
ARA: Arad_12221 Arad_2606(lldD1) Arad_3321(lldD3)
AVI: Avi_5439(lldA) Avi_5754(lldA) Avi_7084
RET: RHE_CH00425(lldD1) RHE_CH01847(lldD2) RHE_CH03131(lldD3)
REC: RHECIAT_CH0000468(lldD1) RHECIAT_CH0001934(lldD2)
RHECIAT_CH0003294(lldD3)
RLE: RL0444(lldD) RL2067(lldD) RL3578(lldD)
RLT: Rleg2_0068 Rleg2_2875 Rleg2_4469
RLG: Rleg_0085 Rleg_1708 Rleg_3143
RHI: NGR_c23940(lldD)
BME: BMEII0377
BMI: BMEA_B0902
BMF: BAB2_0315(lldD)
BMB: BruAb2_0313(lldD)
BMC: BAbS19_II02990
BMS: BRA0920(lldD)
BMT: BSUIS_B0912
BOV: BOV_A0862(lldD)
BCS: BCAN_B0939(lldD)
BMR: BMI_II914(lldD)
OAN: Oant_1448
BJA: bll6401 blr7409
BRA: BRADO5958
BBT: BBta_1816
RPA: RPA4320(lldA)
RPB: RPB_1305
RPC: RPC_4115
RPD: RPD_3916
RPE: RPE_4170
RPT: Rpal_4800
NHA: Nham_1112
OCA: OCAR_7167
BHE: BH02710(lldD)
BQU: BQ02590(lldD)
BTR: Btr_0300(lldD)
BGR: Bgr_02870(lldD)
XAU: Xaut_3929
AZC: AZC_0822 AZC_1655 AZC_2267
MRD: Mrad2831_2545 Mrad2831_3410 Mrad2831_6013
MET: M446_6648
MNO: Mnod_7392
BID: Bind_2622
CCR: CC_1151(lldD)
CCS: CCNA_01209
CAK: Caul_3608(lldD)
PZU: PHZ_c1141(lctD)
SIL: SPO0598 SPO0813 SPO1172
SIT: TM1040_0219 TM1040_2026
RSP: RSP_0829(lctB)
RSH: Rsph17029_2487
RSQ: Rsph17025_0350
RSK: RSKD131_2196
JAN: Jann_3598
RDE: RD1_3375(lldD) RD1_3814(lldD) RD1_3896
PDE: Pden_4075 Pden_4877 Pden_5062
DSH: Dshi_0948(lldD2) Dshi_2484(lldD1)
HNE: HNE_1192(lldD)
HBA: Hbal_2679 Hbal_2760
NAR: Saro_1050(lldD)
SWI: Swit_1643 Swit_4230 Swit_4248 Swit_4638(lldD)
GDI: GDI_0309(lldD)
GDJ: Gdia_2368
MAG: amb4454
MTU: Rv0694(lldD1) Rv1872c(lldD2)
MTC: MT0721 MT1921(lldD)
MRA: MRA_0702(lldD1) MRA_1883(lldD2)
MTF: TBFG_10708 TBFG_11900
MTB: TBMG_00707(TBMG_00707.1) TBMG_02122(TBMG_02122.1)
MBO: Mb0713(lldD1) Mb1903c(lldD2)
MBB: BCG_0743(lldD1) BCG_1908c(lldD2)
MBT: JTY_0713(lldD1) JTY_1892(lldD2)
MLE: ML2046(lldD2)
MLB: MLBr_02046(lldD2)
MPA: MAP1585c(lldD2) MAP4154(lldD1)
MAV: MAV_2843 MAV_4477
MUL: MUL_0774(lldD1) MUL_3002(lldD2)
MAB: MAB_3834c
MMI: MMAR_1022(lldD1) MMAR_2752(lldD2)
CGL: NCgl2817(cgl2918)
CGB: cg3227(lldA)
CGT: cgR_2819
CEF: CE2762
CJK: jk1705(lldD)
CAR: cauri_0795(lldD)
CKP: ckrop_0013(lldD)
NFA: nfa22320 nfa32080 nfa32960(lldD)
RHA: RHA1_ro02988 RHA1_ro10281
RER: RER_18000
ROP: ROP_61310
GBR: Gbro_3777
ART: Arth_3343
AAU: AAur_3324(lldD)
ACH: Achl_3141
RSA: RSal33209_2722
KRH: KRH_12300(lldD)
BCV: Bcav_3293
BFA: Bfae_12000
KSE: Ksed_03020
TCU: Tcur_2361
FRA: Francci3_2407
FRE: Franean1_3205 Franean1_4670
FAL: FRAAL4104
NML: Namu_0776 Namu_5297
KRA: Krad_1384
SEN: SACE_2390(lldD1) SACE_4311(lldD2) SACE_5887(lldD2)
SVI: Svir_13410
CAI: Caci_4852
AFO: Afer_1041
COC: Coch_2077
RBI: RB2501_00931
PMA: Pro1754(lldD)
PMJ: P9211_17191(lldD)
PME: NATL1_20471(lldD)
TER: Tery_2488
TRO: trd_A0844
 |
|---|
| Structures |
PDB: 1FCB 1KBI 1KBJ 1LCO 1LDC 1LTD 1QCW 1SZE 1SZF 1SZG
2OZ0 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:13638255]
APPLEBY CA, MORTON RK.
Lactic dehydrogenase and cytochrome b2 of baker's yeast;
purification and crystallization.
Biochem. J. 71 (1959) 492-9.
Saccharomyces cerevisiae [GN:sce] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:13793977]
APPLEBY CA, MORTON RK.
Lactic dehydrogenase and cytochrome b2 of baker's yeast. Enzymic and
chemical properties of the crystalline enzyme.
Biochem. J. 73 (1959) 539-50.
Saccharomyces cerevisiae [GN:sce] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:16747991]
Bach SJ, Dixon M, Zerfas LG.
Yeast lactic dehydrogenase and cytochrome b(2).
Biochem. J. 40 (1946) 229-39.
Saccharomyces cerevisiae [GN:sce] |
|---|
Reference
Authors
Title
Journal
|
4
Nygaard, A.P.
Lactate dehydrogenases of yeast.
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd
ed., vol. 7, Academic Press, New York, 1963, p. 557-565. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.1.2.3
IUBMB Enzyme Nomenclature: 1.1.2.3
ExPASy - ENZYME nomenclature database: 1.1.2.3
BRENDA, the Enzyme Database: 1.1.2.3
CAS: 9078-32-4 |
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