| Entry |
|
|---|
| Name |
vitamin-K-epoxide reductase (warfarin-sensitive) |
|---|
| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With a disulfide as acceptor
 |
|---|
| Sysname |
2-methyl-3-phytyl-1,4-naphthoquinone:oxidized-dithiothreitol
oxidoreductase |
|---|
| Reaction(IUBMB) |
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol =
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone +
1,4-dithiothreitol [RN:R03511] |
|---|
| Reaction(KEGG) |
R03511;
(other) R03645
 |
|---|
| Substrate |
2-methyl-3-phytyl-1,4-naphthoquinone [CPD:C02059];
oxidized dithiothreitol [CPD:C01119] |
|---|
| Product |
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone
[CPD:C05849];
1,4-dithiothreitol [CPD:C00265] |
|---|
| Inhibitor |
Warfarin [CPD:C01541] |
|---|
| Comment |
In the reverse reaction, vitamin K 2,3-epoxide is reduced to vitamin
K and possibly to vitamin K hydroquinone by 1,4-dithiothreitol,
which is oxidized to a disulfide; some other dithiols and
4-butanethiol can also act. Inhibited strongly by warfarin [cf. EC
1.1.4.2 vitamin-K-epoxide reductase (warfarin-insensitive)]. |
|---|
| Orthology |
KO: K05357 vitamin-K-epoxide reductase (warfarin-sensitive) |
|---|
| Genes |
HSA: 79001(VKORC1)
MMU: 27973(Vkorc1)
RNO: 309004(Vkorc1)
CFA: 479775(VKORC1)
BTA: 445422(VKORC1)
ECB: 100063360
GGA: 404205(VKORC1)
DME: Dmel_CG33544(Vkor)
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:6733086]
Lee JJ, Fasco MJ.
Metabolism of vitamin K and vitamin K 2,3-epoxide via interaction
with a common disulfide.
Biochemistry. 23 (1984) 2246-52.
Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:3857611]
Mukharji I, Silverman RB.
Purification of a vitamin K epoxide reductase that catalyzes
conversion of vitamin K 2,3-epoxide to
3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone.
Proc. Natl. Acad. Sci. U. S. A. 82 (1985) 2713-7.
Bos taurus [GN:bta] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:646989]
Whitlon DS, Sadowski JA, Suttie JW.
Mechanism of coumarin action: significance of vitamin K epoxide
reductase inhibition.
Biochemistry. 17 (1978) 1371-7.
Rattus norvegicus [GN:rno] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.1.4.1
IUBMB Enzyme Nomenclature: 1.1.4.1
ExPASy - ENZYME nomenclature database: 1.1.4.1
BRENDA, the Enzyme Database: 1.1.4.1
CAS: 55963-40-1 |
|---|
