KEGG   ENZYME: 1.1.4.2Help
Entry
EC 1.1.4.2                  Enzyme                                 

Name
vitamin-K-epoxide reductase (warfarin-insensitive)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With a disulfide as acceptor
BRITE hierarchy
Sysname
3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone:oxidized-dithiothreitol oxidoreductase
Reaction(IUBMB)
3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol [RN:R03512]
Reaction(KEGG)
R03512;
(other) R05830
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Substrate
3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone [CPD:C02785];
oxidized dithiothreitol [CPD:C01119]
Product
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone [CPD:C05849];
1,4-dithiothreitol [CPD:C00265]
Comment
In the reverse reaction, vitamin K 2,3-epoxide is reduced to 3-hydroxy- (and 2-hydroxy-) vitamin K by 1,4-dithiothreitol, which is oxidized to a disulfide. Not inhibited by warfarin [cf. EC 1.1.4.1 vitamin-K-epoxide reductase (warfarin-sensitive)].
History
EC 1.1.4.2 created 1989
Reference
1  [PMID:3857611]
  Authors
Mukharji I, Silverman RB.
  Title
Purification of a vitamin K epoxide reductase that catalyzes conversion of vitamin K 2,3-epoxide to 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 82 (1985) 2713-7.
  Organism
Bos taurus [GN:bta]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
97089-80-0

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