| Entry |
|
| Name |
glucose 1-dehydrogenase (PQQ, quinone);
quinoprotein glucose dehydrogenase;
membrane-bound glucose dehydrogenase;
mGDH;
glucose dehydrogenase (PQQ-dependent);
glucose dehydrogenase (pyrroloquinoline-quinone);
quinoprotein D-glucose dehydrogenase
|
| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With a quinone or similar compound as acceptor
 |
| Sysname |
D-glucose:ubiquinone oxidoreductase
|
| Reaction(IUBMB) |
D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol [RN: R06620]
|
| Reaction(KEGG) |
|
| Substrate |
|
| Product |
|
| Comment |
Integral membrane protein containing PQQ as prosthetic group. It also contains bound ubiquinone and Mg2+ or Ca2+. Electron acceptor is membrane ubiquinone but usually assayed with phenazine methosulfate. Like in all other quinoprotein alcohol dehydrogenases the catalytic domain has an 8-bladed propeller structure. It occurs in a wide range of bacteria. Catalyses a direct oxidation of the pyranose form of D-glucose to the lactone and thence to D-gluconate in the periplasm. Oxidizes other monosaccharides including the pyranose forms of pentoses.
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| Pathway |
| Pentose phosphate pathway | | Metabolic pathways | | Biosynthesis of secondary metabolites |
|
| Orthology |
| quinoprotein glucose dehydrogenase |
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| Genes |
ECO: | | ECJ: | | ECD: | | EBW: | | ECOK: | | ECE: | | ECS: | | ECF: | | ETW: | | ELX: | | EOJ: | | EOI: | | EOH: | | ECG: | | EOK: | | ELR: | | ECC: | | ECP: | | ECI: | | ECV: | | ECX: | | ECW: | | ECM: | | ECY: | | ECR: | | ECQ: | | ECK: | | ECT: | | EOC: | | EUM: | | ECZ: | | ELO: | | ELN: | | ELH: | | ESE: | | ESO: | | ESM: | | ESL: | | ECL: | | EBR: | | EBD: | | EKO: | | EKF: | | EAB: | | EDH: | | EDJ: | | EIH: | | ENA: | | ELU: | | EUN: | | ELW: | | ELL: | | ELC: | | ELD: | | EBL: | | EBE: | | ELF: | | ECOA: | | EFE: | | STY: | | STT: | | SEX: | | SENT: | | STM: | | SEO: | | SEV: | | SEY: | | SEM: | | SEJ: | | SEB: | | SEF: | | SETU: | | SPT: | | SEK: | | SPQ: | | SEI: | | SEC: | | SEH: | | SHB: | | SEE: | | SEW: | | SEA: | | SED: | | SEL: | | SET: | | SENJ: | | SES: | | SBG: | | SFL: | | SFX: | | SFV: | | SFE: | | SSN: | | SSJ: | | SBO: | | ETA: | | EPY: | | EPR: | | EAM: | | EAY: | | EBI: | | ERJ: | | ENT: | | ENC: | | ENO: | | ECLO: | | ESC: | | EEC: | | ENL: | | EAS: | | EAE: | | EAR: | | ESA: | | CSK: | | CSZ: | | CTU: | | KPN: | | KPU: | | KPM: | | KPP: | | KPE: | | KPO: | | KVA: | | KOX: | | CKO: | | CRO: | | SPE: | | SRR: | | SRS: | | SRA: | | SMAF: | | SMW: | | PMR: | | PAM: | | PLF: | | PAJ: | | PAQ: | | PVA: | | PAO: | | RAH: | | RAQ: | | RAA: | | ROR: | | EBF: | | XCC: | | XCB: | | XCA: | | XCV: | | XCP: | | XAC: | | XAX: | | XAO: | | XOR: | | XCI: | | SML: | | SMT: | | BUJ: | | SMZ: | | FAU: | | PAE: | | PAU: | | PAP: | | PAG: | | PAF: | | PNC: | | PDK: | | PSG: | | PPU: | | PPF: | | PPG: | | PPW: | | PPT: | | PPB: | | PPI: | | PPX: | | PPUH: | | PPUU: | | PST: | | PSB: | | PSP: | | PFL: | | PFO: | | PFS: | | PFE: | | PFC: | | PPZ: | | PEN: | | PMY: | | PMK: | | PSA: | | PSZ: | | PSR: | | PSC: | | PSJ: | | PSH: | | PBA: | | PFV: | | AVN: | | AVL: | | AVD: | | PAR: | | PRW: | | ACI: | | ACD: | | ACB: | | ABM: | | ABY: | | ABC: | | ABN: | | ABB: | | ABX: | | ABZ: | | ABR: | | ABD: | | ABH: | | ABAD: | | ACC: | | ILO: | | PAT: | | GAG: | | PIN: | | NWA: | | CSA: | | HEL: | | ADI: | | MMW: | | BCT: | | BXE: | | BPH: | | BPY: | | BGL: | | BUG: | | BGE: | | BGF: | | BGD: | | BYI: | | BPX: | | BPT: | | AKA: | | AAV: | | AAA: | | DAC: | | DEL: | | VAP: | | VPE: | | MPT: | | RGE: | | PUB: | | MLO: | | MCI: | | MOP: | | MAM: | | MES: | | PLA: | | SME: | | SMK: | | SMQ: | | SMX: | | SMI: | | SMEG: | | SMEL: | | SMD: | | RHI: | | SFH: | | SFD: | | ATU: | | ARA: | | AVI: | | AGR: | | RET: | | REC: | | RLE: | | RLT: | | RLG: | | RTR: | | OAN: | | BJU: | | BRA: | | BBT: | | BRS: | | RPB: | | RPT: | | RPX: | | AOL: | | MRD: | | PHL: | | PZU: | | RSP: | | RSH: | | RSQ: | | RSK: | | KVU: | | KVL: | | NPP: | | SWI: | | SPHM: | | SJP: | | SCH: | | SSY: | | GOX: | | GOH: | | GDI: | | GDJ: | | GXY: | | APT: | | APW: | | APF: | | APU: | | APG: | | APQ: | | APX: | | APZ: | | RCE: | | AZL: | | ALI: | | TMO: | | APM: | | GMA: | | TSA: | | TRS: | | SUS: | | CPI: | | SHG: | | HHY: | | CMR: | | DFE: | | SLI: | | LBY: | | RSI: | | EOL: | | FAE: | | GFO: | | RBI: | | FBC: | | ZGA: | | MRS: | | OTE: | | GAU: | | RBA: | | SACI: | | TTH: | | HMA: | | » show all
 |
| Reference |
|
| Authors |
Yamada M, Sumi K, Matsushita K, Adachi O, Yamada Y. |
| Title |
Topological analysis of quinoprotein glucose dehydrogenase in Escherichia coli and its ubiquinone-binding site. |
| Journal |
J. Biol. Chem. 268 (1993) 12812-7. |
| Organism |
Escherichia coli [GN: eco] |
| Reference |
|
| Authors |
Dewanti AR, Duine JA. |
| Title |
Reconstitution of membrane-integrated quinoprotein glucose dehydrogenase apoenzyme with PQQ and the holoenzyme's mechanism of action. |
| Journal |
Biochemistry. 37 (1998) 6810-8. |
| Organism |
Acinetobacter calcoaceticus |
| Reference |
|
| Authors |
Duine JA, Frank J, van Zeeland JK. |
| Title |
Glucose dehydrogenase from Acinetobacter calcoaceticus: a 'quinoprotein'. |
| Journal |
FEBS. Lett. 108 (1979) 443-6. |
| Organism |
Acinetobacter calcoaceticus |
| Reference |
|
| Authors |
Ameyama M, Matsushita K, Ohno Y, Shinagawa E, Adachi O |
| Title |
Existence of a novel prosthetic group, PQQ, in membrane-bound, electron transport chain-linked, primary dehydrogenases of oxidative bacteria. |
| Journal |
FEBS. Lett. 130 (1981) 179-83. |
| Reference |
|
| Authors |
Cozier GE, Anthony C |
| Title |
Structure of the quinoprotein glucose dehydrogenase of Escherichia coli modelled on that of methanol dehydrogenase from Methylobacterium extorquens. |
| Journal |
Biochem. J. 312 ( Pt 3) (1995) 679-85. |
| Reference |
|
| Authors |
Cozier GE, Salleh RA, Anthony C |
| Title |
Characterization of the membrane quinoprotein glucose dehydrogenase from Escherichia coli and characterization of a site-directed mutant in which histidine-262 has been changed to tyrosine. |
| Journal |
Biochem. J. 340 ( Pt 3) (1999) 639-47. |
| Reference |
|
| Authors |
Elias M, Tanaka M, Sakai M, Toyama H, Matsushita K, Adachi O, Yamada M. |
| Title |
C-terminal periplasmic domain of Escherichia coli quinoprotein glucose dehydrogenase transfers electrons to ubiquinone. |
| Journal |
J. Biol. Chem. 276 (2001) 48356-61. |
| Organism |
Escherichia coli [GN: eco] |
| Reference |
|
| Authors |
James PL, Anthony C |
| Title |
The metal ion in the active site of the membrane glucose dehydrogenase of Escherichia coli. |
| Journal |
Biochim. Biophys. Acta. 1647 (2003) 200-5. |
| Reference |
|
| Authors |
Elias MD, Nakamura S, Migita CT, Miyoshi H, Toyama H, Matsushita K, Adachi O, Yamada M |
| Title |
Occurrence of a bound ubiquinone and its function in Escherichia coli membrane-bound quinoprotein glucose dehydrogenase. |
| Journal |
J. Biol. Chem. 279 (2004) 3078-83. |
| Reference |
|
| Authors |
Mustafa G, Ishikawa Y, Kobayashi K, Migita CT, Elias MD, Nakamura S, Tagawa S, Yamada M |
| Title |
Amino acid residues interacting with both the bound quinone and coenzyme, pyrroloquinoline quinone, in Escherichia coli membrane-bound glucose dehydrogenase. |
| Journal |
J. Biol. Chem. 283 (2008) 22215-21. |
| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 81669-60-5 |