KEGG   ENZYME: 1.1.99.2Help
Entry
EC 1.1.99.2                 Enzyme                                 

Name
L-2-hydroxyglutarate dehydrogenase;
alpha-ketoglutarate reductase;
alpha-hydroxyglutarate dehydrogenase;
L-alpha-hydroxyglutarate dehydrogenase;
hydroxyglutaric dehydrogenase;
alpha-hydroxyglutarate oxidoreductase;
L-alpha-hydroxyglutarate:NAD+ 2-oxidoreductase;
alpha-hydroxyglutarate dehydrogenase (NAD+ specific);
(S)-2-hydroxyglutarate:(acceptor) 2-oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With other, unknown, acceptors
BRITE hierarchy
Sysname
(S)-2-hydroxyglutarate:acceptor 2-oxidoreductase
Reaction(IUBMB)
(S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor [RN:R00298]
Reaction(KEGG)
Substrate
(S)-2-hydroxyglutarate [CPD:C03196];
acceptor [CPD:C00028]
Product
2-oxoglutarate [CPD:C00026];
reduced acceptor [CPD:C00030]
History
EC 1.1.99.2 created 1961, modified 2013
Pathway
Butanoate metabolism
Orthology
K00109  
2-hydroxyglutarate dehydrogenase
Genes
HSA: 
79944(L2HGDH)
PTR: 
452898(L2HGDH)
PPS: 
100978899(L2HGDH)
GGO: 
101139276(L2HGDH)
PON: 
100172827(L2HGDH)
NLE: 
100600833(L2HGDH)
MCC: 
705721(L2HGDH)
MCF: 
102137911(L2HGDH)
CJC: 
100410851(L2HGDH)
MMU: 
217666(L2hgdh)
RNO: 
314196(L2hgdh)
CGE: 
100768751(L2hgdh)
NGI: 
103731511(L2hgdh)
HGL: 
101702109(L2hgdh)
OCU: 
100350193(L2HGDH)
TUP: 
102480205(L2HGDH)
CFA: 
480316(L2HGDH)
AML: 
UMR: 
103665372(L2HGDH)
FCA: 
101094353(L2HGDH)
PTG: 
102951061(L2HGDH)
BTA: 
514230(L2HGDH)
BOM: 
102277294(L2HGDH)
PHD: 
102328606(L2HGDH)
CHX: 
102190421(L2HGDH)
OAS: 
101121015(L2HGDH)
SSC: 
100152180(L2HGDH)
CFR: 
102520166(L2HGDH)
BACU: 
103020579(L2HGDH)
LVE: 
103075209(L2HGDH)
ECB: 
100066314(L2HGDH)
MYB: 
102238888(L2HGDH)
MYD: 
102773864(L2HGDH)
PALE: 
102889350(L2HGDH)
MDO: 
SHR: 
OAA: 
100084662(L2HGDH)
GGA: 
423573(L2HGDH)
MGP: 
APLA: 
101804444(L2HGDH)
TGU: 
100220092(L2HGDH)
FAB: 
101808533(L2HGDH)
PHI: 
102103991(L2HGDH)
FPG: 
101912902(L2HGDH)
FCH: 
102056594(L2HGDH)
CLV: 
102089678(L2HGDH)
ASN: 
102387436(L2HGDH)
AMJ: 
102572638(L2HGDH)
PSS: 
102458506(L2HGDH)
CMY: 
102946571(L2HGDH)
ACS: 
100563174(l2hgdh)
PBI: 
103059564(L2HGDH)
XTR: 
100145085(l2hgdh)
DRE: 
566872(l2hgdh)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102364974(L2HGDH)
CMK: 
103175273(l2hgdh)
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
CQU: 
AME: 
410999(GB16589)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CELE_Y45G12B.3(Y45G12B.3)
CBR: 
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
SMM: 
NVE: 
TAD: 
AQU: 
SMO: 
PPP: 
CME: 
GSL: 
MBR: 
DDI: 
DPP: 
TRO: 
TTR: 
 » show all
Taxonomy
Reference
1  [PMID:16746551]
  Authors
Weil-Malherbe H
  Title
The oxidation of l(-)alpha-hydroxyglutaric acid in animal tissues.
  Journal
Biochem. J. 31 (1937) 2080-94.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9028-80-2

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