| Entry |
|
|---|
| Name |
phospholipid-hydroperoxide glutathione peroxidase;
peroxidation-inhibiting protein;
PHGPX;
peroxidation-inhibiting protein: peroxidase, glutathione
(phospholipid hydroperoxide-reducing);
phospholipid hydroperoxide glutathione peroxidase;
hydroperoxide glutathione peroxidase |
|---|
| Class |
Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxidases
 |
|---|
| Sysname |
glutathione:lipid-hydroperoxide oxidoreductase |
|---|
| Reaction(IUBMB) |
2 glutathione + a lipid hydroperoxide = glutathione disulfide +
lipid + 2 H2O [RN:R03167] |
|---|
| Reaction(KEGG) |
R03167
 |
|---|
| Substrate |
glutathione [CPD:C00051];
lipid hydroperoxide [CPD:C01025] |
|---|
| Product |
glutathione disulfide [CPD:C00127];
lipid [CPD:C01356];
H2O [CPD:C00001] |
|---|
| Comment |
A protein containing a selenocysteine residue. The products of
action of EC 1.13.11.12 lipoxygenase on phospholipids can act as
acceptor; H2O2 can also act, but much more slowly (cf. EC 1.11.1.9
glutathione peroxidase). |
|---|
| Pathway |
PATH: ec00480 Glutathione metabolism |
|---|
| Orthology |
KO: K05361 phospholipid-hydroperoxide glutathione peroxidase |
|---|
| Genes |
PTR: 741876(GPX4)
MCC: 705333(GPX4)
MMU: 625249(Gpx4)
RNO: 29328(Gpx4)
DRE: 352928(gpx4a) 352929(gpx4b)
TET: TTHERM_00046090 TTHERM_00046110 TTHERM_00895630 TTHERM_00895640
TTHERM_01099010
 |
|---|
| Structures |
PDB: 2GS3 2OBI |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:3978121]
Ursini F, Maiorino M, Gregolin C.
The selenoenzyme phospholipid hydroperoxide glutathione peroxidase.
Biochim. Biophys. Acta. 839 (1985) 62-70.
Sus scofa [GN:ssc] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.11.1.12
IUBMB Enzyme Nomenclature: 1.11.1.12
ExPASy - ENZYME nomenclature database: 1.11.1.12
BRENDA, the Enzyme Database: 1.11.1.12
CAS: 97089-70-8 |
|---|
