| Entry |
|
|---|
| Name |
ferredoxin hydrogenase;
H2 oxidizing hydrogenase;
H2 producing hydrogenase [ambiguous];
bidirectional hydrogenase;
hydrogen-lyase [ambiguous];
hydrogenase (ferredoxin);
hydrogenase I;
hydrogenase II;
hydrogenlyase [ambiguous];
uptake hydrogenase [ambiguous] |
|---|
| Class |
Oxidoreductases;
Acting on hydrogen as donor;
With an iron-sulfur protein as acceptor
 |
|---|
| Sysname |
hydrogen:ferredoxin oxidoreductase |
|---|
| Reaction(IUBMB) |
H2 + 2 oxidized ferredoxin = 2 reduced ferredoxin + 2 H+ [RN:R00019] |
|---|
| Reaction(KEGG) |
R00019
 |
|---|
| Substrate |
H2 [CPD:C00282];
oxidized ferredoxin [CPD:C00139] |
|---|
| Product |
reduced ferredoxin [CPD:C00138];
H+ [CPD:C00080] |
|---|
| Cofactor |
Iron [CPD:C00023];
Sulfur [CPD:C00087];
Nickel [CPD:C00291] |
|---|
| Comment |
Contains iron-sulfur clusters. The enzymes from some sources
contains nickel. Can use molecular hydrogen for the reduction of a
variety of substances. |
|---|
| Pathway |
PATH: ec00630 Glyoxylate and dicarboxylate metabolism
PATH: ec00680 Methane metabolism |
|---|
| Orthology |
KO: K00532 ferredoxin hydrogenase
KO: K00533 ferredoxin hydrogenase large subunit
KO: K00534 ferredoxin hydrogenase small subunit
KO: K06441 ferredoxin hydrogenase gamma subunit |
|---|
| Genes |
DHA: DEHA0C11418g
AFM: AFUA_4G11960
TPV: TP03_0164
TET: TTHERM_00198090
SON: SO_3920(hydA) SO_3921(hydB)
SHE: Shewmr4_3250
SHN: Shewana3_0710 Shewana3_0711 Shewana3_3459
RFR: Rfer_4120
PNA: Pnap_1955
MPT: Mpe_A2807
DAR: Daro_3961
PCA: Pcar_2502(hyd)
DVU: DVU1769(hydA) DVU1770(hydB) DVU1771(hydC) DVU1917(hysB)
DVU1918(hysA) DVU1921(hynB-1) DVU2525(hynB-2) DVU2526(hynA-2)
DVL: Dvul_0718 Dvul_0719 Dvul_1384 Dvul_1385 Dvul_1386
DDE: Dde_0081 Dde_0082 Dde_0475 Dde_2280 Dde_2281 Dde_3755 Dde_3756
DPS: DP0159 DP0160 DP0479
SFU: Sfum_0847 Sfum_0848
BJA: bll6944(hupU)
BRA: BRADO1682(hupU)
BBT: BBta_1994(hupU)
RPA: RPA0134(hydC) RPA0959(hupU)
RPE: RPE_1229 RPE_3860
RSP: RSP_0492(hupU)
RSH: Rsph17029_2143
RRU: Rru_A0310
CPR: CPR_0261 CPR_0938 CPR_2341(hydA)
CTC: CTC02417
CNO: NT01CX_0464 NT01CX_1006 NT01CX_1699 NT01CX_2259
CTH: Cthe_3003
CDF: CD3314(hydA)
CPY: Cphy_0090
SWO: Swol_1925
EEL: EUBELI_01405
ERE: EUBREC_2390
CHY: CHY_1545
MTA: Moth_1883
 |
|---|
| Structures |
PDB: 3C8Y |
|---|
Reference
Authors
Title
Journal
|
1
Shug, A.L., Wilson, P.W., Green, D.E. and Mahler, H.R.
The role of molybdenum and flavin in hydrogenase.
J. Am. Chem. Soc. 76 (1954) 3355-3356. |
|---|
Reference
Authors
Title
Journal
|
2
Tagawa, K. and Arnon, D.I.
Ferredoxin as electron carriers in photosynthesis and in the
bioogical production and consumption of hydrogen gas.
Nature (Lond.) 195 (1962) 537-543. |
|---|
Reference
Authors
Title
Journal
|
3
Valentine, R.C., Mortenson, L.E. and Carnahan, J.E.
The hydrogenase system of Clostridium pasteurianum.
J. Biol. Chem. 238 (1963) 1141-1144. |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:164247]
Zumft WG, Mortenson LE.
The nitrogen-fixing complex of bacteria.
Biochim. Biophys. Acta. 416 (1975) 1-52.
Clostridium pasteurianum |
|---|
Reference
Authors
Title
Journal
Organism
|
5 [PMID:2173950]
Adams MW.
The structure and mechanism of iron-hydrogenases.
Biochim. Biophys. Acta. 1020 (1990) 115-45.
Desulfovibrio vulgaris, Clostridium pasteurianum, Megasphaera
elsdenii |
|---|
Reference
Authors
Title
Journal
Organism
|
6 [PMID:9836629]
Peters JW, Lanzilotta WN, Lemon BJ, Seefeldt LC.
X-ray crystal structure of the Fe-only hydrogenase (CpI) from
Clostridium pasteurianum to 1.8 angstrom resolution.
Science. 282 (1998) 1853-8.
Clostridium pasteurianum |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.12.7.2
IUBMB Enzyme Nomenclature: 1.12.7.2
ExPASy - ENZYME nomenclature database: 1.12.7.2
UM-BBD (Biocatalysis/Biodegradation Database): 1.12.7.2
BRENDA, the Enzyme Database: 1.12.7.2
CAS: 9027-05-8 |
|---|
