| Entry |
|
|---|
| Name |
cysteamine dioxygenase;
persulfurase;
cysteamine oxygenase;
cysteamine:oxygen oxidoreductase |
|---|
| Class |
Oxidoreductases;
Acting on single donors with O2 as oxidant and incorporation of
oxygen into the substrate (oxygenases). The oxygen incorporated need
not be derived from O2;
With incorporation of two atoms of oxygen
 |
|---|
| Sysname |
2-aminoethanethiol:oxygen oxidoreductase |
|---|
| Reaction(IUBMB) |
2-aminoethanethiol + O2 = hypotaurine [RN:R02467] |
|---|
| Reaction(KEGG) |
R02467
 |
|---|
| Substrate |
2-aminoethanethiol [CPD:C01678];
O2 [CPD:C00007] |
|---|
| Product |
hypotaurine [CPD:C00519] |
|---|
| Cofactor |
Iron [CPD:C00023] |
|---|
| Comment |
A non-heme iron protein that is involved in the biosynthesis of
taurine. Requires catalytic amounts of a cofactor-like compound,
such as sulfur, sufide, selenium or methylene blue for maximal
activity. 3-Aminopropanethiol (homocysteamine) and 2-mercaptoethanol
can also act as substrates, but glutathione, cysteine, and cysteine
ethyl- and methyl esters are not good substrates [1,3]. |
|---|
| Pathway |
PATH: ec00430 Taurine and hypotaurine metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K10712 cysteamine dioxygenase |
|---|
| Genes |
HSA: 84890(ADO)
PTR: 748534(ADO)
MCC: 698259(ADO)
MMU: 211488(Ado)
RNO: 309732(Ado)
CFA: 489003
SSC: 100153304
MDO: 100017045
OAA: 100079506
DRE: 406474(adob)
DPO: Dpse_GA20432
NVE: NEMVE_v1g245692
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:5912113]
Cavallini D, De Marco C, Scandurra R, Dupre S, Graziani MT.
The enzymatic oxidation of cysteamine to hypotaurine. Purification
and properties of the enzyme.
J. Biol. Chem. 241 (1966) 3189-96.
Equus caballus [GN:ecb] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:6052430]
Wood JL, Cavallini D.
Enzymic oxidation of cysteamine to hypotaurine in the absence of a
cofactor.
Arch. Biochem. Biophys. 119 (1967) 368-72.
Equus caballus [GN:ecb] |
|---|
Reference
Authors
Title
Journal
|
3 [PMID:1157952]
Cavallini D, Federici G, Ricci G, Dupre S, Antonucci A.
The specificity of cysteamine oxygenase.
FEBS. Lett. 56 (1975) 348-51. |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:3657558]
Richerson RB, Ziegler DM.
Cysteamine dioxygenase.
Methods. Enzymol. 143 (1987) 410-5.
Equus caballus [GN:ecb] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.13.11.19
IUBMB Enzyme Nomenclature: 1.13.11.19
ExPASy - ENZYME nomenclature database: 1.13.11.19
BRENDA, the Enzyme Database: 1.13.11.19
CAS: 9033-41-4 |
|---|
