KEGG   ENZYME: 1.13.11.19Help
Entry
EC 1.13.11.19               Enzyme                                 

Name
cysteamine dioxygenase;
persulfurase;
cysteamine oxygenase;
cysteamine:oxygen oxidoreductase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
2-aminoethanethiol:oxygen oxidoreductase
Reaction(IUBMB)
2-aminoethanethiol + O2 = hypotaurine [RN:R02467]
Reaction(KEGG)
Substrate
2-aminoethanethiol [CPD:C01678];
O2 [CPD:C00007]
Product
hypotaurine [CPD:C00519]
Comment
A non-heme iron protein that is involved in the biosynthesis of taurine. Requires catalytic amounts of a cofactor-like compound, such as sulfur, sufide, selenium or methylene blue for maximal activity. 3-Aminopropanethiol (homocysteamine) and 2-mercaptoethanol can also act as substrates, but glutathione, cysteine, and cysteine ethyl- and methyl esters are not good substrates [1,3].
History
EC 1.13.11.19 created 1972, modified 2006
Pathway
Taurine and hypotaurine metabolism
Metabolic pathways
Orthology
K10712  
cysteamine dioxygenase
Genes
HSA: 
84890(ADO)
PTR: 
748534(ADO)
PPS: 
GGO: 
PON: 
MCC: 
698259(ADO)
MCF: 
MMU: 
211488(Ado)
RNO: 
309732(Ado)
HGL: 
TUP: 
CFA: 
AML: 
FCA: 
BTA: 
BOM: 
PHD: 
CHX: 
SSC: 
ECB: 
MYB: 
MYD: 
PALE: 
MDO: 
OAA: 
FAB: 
PHI: 
ASN: 
XLA: 
XTR: 
DRE: 
406474(adob)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
BFO: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
724666(GB12350)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
LOA: 
TSP: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
ATH: 
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
MTR: 
CAM: 
FVE: 
CSV: 
RCU: 
POP: 
POPTR_0004s05670g(POPTRDRAFT_555667) POPTR_0004s13450g(POPTRDRAFT_858831) POPTR_0011s07260g(POPTRDRAFT_568704) POPTR_0012s05400g(POPTRDRAFT_729118) POPTR_0013s06040g(POPTRDRAFT_893757) POPTR_0015s06600g POPTR_0019s05510g(POPTRDRAFT_780310)
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os01t0185500-00(Os01g0185500) Os03t0655100-00(Os03g0655100) Os04t0151900-01(Os04g0151900) Os05t0592300-01(Os05g0592300) Os08t0133000-01(Os08g0133000) Os08t0133700-00(Os08g0133700) Os08t0480400-01(Os08g0480400) Os12t0623600-01(Os12g0623600)
OBR: 
BDI: 
SBI: 
SORBI_01g013030(SORBIDRAFT_01g013030) SORBI_03g003375(SORBIDRAFT_03g003375) SORBI_06g032140(SORBIDRAFT_06g032140) SORBI_07g029100(SORBIDRAFT_07g029100) SORBI_08g022140(SORBIDRAFT_08g022140)
ZMA: 
SITA: 
ATR: 
s00006p00263680(AMTR_s00006p00263680) s00021p00022250(AMTR_s00021p00022250) s00078p00120410(AMTR_s00078p00120410)
SMO: 
PPP: 
VCN: 
OTA: 
MIS: 
MPP: 
CSL: 
CME: 
GSL: 
DPP: 
PTM: 
PIF: 
EHX: 
GTT: 
 » show all
Taxonomy
Reference
1  [PMID:5912113]
  Authors
Cavallini D, De Marco C, Scandurra R, Dupre S, Graziani MT.
  Title
The enzymatic oxidation of cysteamine to hypotaurine. Purification and properties of the enzyme.
  Journal
J. Biol. Chem. 241 (1966) 3189-96.
  Organism
Equus caballus
Reference
2  [PMID:6052430]
  Authors
Wood JL, Cavallini D.
  Title
Enzymic oxidation of cysteamine to hypotaurine in the absence of a cofactor.
  Journal
Arch. Biochem. Biophys. 119 (1967) 368-72.
  Organism
Equus caballus
Reference
3  [PMID:1157952]
  Authors
Cavallini D, Federici G, Ricci G, Dupre S, Antonucci A.
  Title
The specificity of cysteamine oxygenase.
  Journal
FEBS. Lett. 56 (1975) 348-51.
Reference
4  [PMID:3657558]
  Authors
Richerson RB, Ziegler DM.
  Title
Cysteamine dioxygenase.
  Journal
Methods. Enzymol. 143 (1987) 410-5.
  Organism
Equus caballus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9033-41-4

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