KEGG   ENZYME: 1.13.11.2Help
Entry
EC 1.13.11.2                Enzyme                                 

Name
catechol 2,3-dioxygenase;
2,3-pyrocatechase;
catechol 2,3-oxygenase;
catechol oxygenase;
metapyrocatechase;
pyrocatechol 2,3-dioxygenase;
xylE (gene name)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
catechol:oxygen 2,3-oxidoreductase (decyclizing)
Reaction(IUBMB)
catechol + O2 = 2-hydroxymuconate-6-semialdehyde [RN:R00816]
Reaction(KEGG)
Substrate
catechol [CPD:C00090];
O2 [CPD:C00007]
Product
2-hydroxymuconate-6-semialdehyde [CPD:C00682]
Comment
Requires FeII. The enzyme initiates the meta-cleavage pathway of catechol degradation.
History
EC 1.13.11.2 created 1965 as EC 1.13.1.2, transferred 1972 to EC 1.13.11.2, modified 1999, modified 2013
Pathway
Chlorocyclohexane and chlorobenzene degradation
Benzoate degradation
Xylene degradation
Styrene degradation
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K00446  
catechol 2,3-dioxygenase
Genes
SLQ: 
PAO: 
ROR: 
EBF: 
PSD: 
PPI: 
ND089(nahH)
PSC: 
AVN: 
Avin_08720(xylE) Avin_08800(dmpB) Avin_30770(lapB)
AVL: 
AvCA_08720(xylE) AvCA_08800(dmpB) AvCA_30770(lapB)
AVD: 
MAD: 
CYQ: 
Q91_0505(xylE)
CZA: 
RPI: 
RPF: 
REU: 
REH: 
CNC: 
RME: 
Rmet_1324(dmpB)
BVI: 
BUR: 
BCT: 
PPK: 
PRB: 
BAV: 
CDN: 
AJS: 
VEI: 
CTT: 
ADN: 
ADK: 
MPT: 
LCH: 
AZO: 
azo1844(lapB1) azo1858(xylE) azo2438(lapB2)
DAR: 
TMZ: 
ARC: 
MCI: 
MOP: 
MES: 
RHI: 
SFH: 
EAD: 
ARA: 
REC: 
RLE: 
RLT: 
RTR: 
BME: 
BMI: 
BMZ: 
BMG: 
BMW: 
BMF: 
BMB: 
BMC: 
BAA: 
BMT: 
BSK: 
BMR: 
BPP: 
BCET: 
BCEE: 
BJA: 
BJU: 
BRA: 
BBT: 
BRS: 
RPA: 
RPB: 
RPD: 
RPT: 
RPX: 
MSL: 
PHL: 
SIL: 
SIT: 
RSP: 
RSH: 
JAN: 
PGA: 
PGL: 
PGD: 
LMD: 
NAR: 
NPP: 
SJP: 
PGV: 
BACI: 
GTH: 
GCT: 
GMC: 
GJF: 
LGY: 
AAC: 
AAD: 
BTS: 
SIV: 
ECAS: 
TMR: 
SAY: 
SAP: 
CAR: 
NFA: 
NNO: 
RHA: 
ROP: 
ROA: 
RPY: 
GBR: 
SMA: 
SAV_1615(xylE)
SVL: 
SRC: 
MTS: 
ART: 
ACH: 
APN: 
ARR: 
CFI: 
ICA: 
TCU: 
BSD: 
MMAR: 
AMD: 
AMN: 
AMM: 
AMZ: 
PDX: 
KAL: 
AFS: 
RXY: 
CWO: 
TPI: 
SLI: 
RSI: 
EOL: 
RRS: 
RCA: 
CAU: 
CAG: 
CHL: 
TRO: 
STI: 
CAP: 
DRA: 
DGE: 
DMR: 
DPT: 
DGO: 
DPD: 
TTH: 
TTJ: 
TTS: 
TTL: 
TSC: 
THC: 
TOS: 
MRB: 
MRE: 
MSV: 
MHD: 
SSO: 
STO: 
SAI: 
Saci_2295(xylE)
SACN: 
SACR: 
SACS: 
SIS: 
SID: 
SIN: 
SII: 
SIH: 
SIR: 
SIC: 
MSE: 
MCN: 
POG: 
 » show all
Taxonomy
Reference
1
  Authors
Hayaishi, O.
  Title
Direct oxygenation by O2, oxygenases.
  Journal
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 8, Academic Press, New York, 1963, p. 353-371.
Reference
2  [PMID:13757654]
  Authors
KOJIMA Y, ITADA N, HAYAISHI O.
  Title
Metapyrocatachase: a new catechol-cleaving enzyme.
  Journal
J. Biol. Chem. 236 (1961) 2223-8.
  Organism
Pseudomonas sp.
Reference
3  [PMID:14087325]
  Authors
NOZAKI M, KAGAMIYAMA H, HAYAISHI O.
  Title
METAPYROCATECHASE. I. PURIFICATION, CRYSTALLIZATION AND SOME PROPERTIES.
  Journal
Biochem. Z. 338 (1963) 582-90.
  Organism
Pseudomonas arvilla
Reference
4  [PMID:6826545]
  Authors
Nakai C, Hori K, Kagamiyama H, Nakazawa T, Nozaki M
  Title
Purification, subunit structure, and partial amino acid sequence of metapyrocatechase.
  Journal
J. Biol. Chem. 258 (1983) 2916-22.
Reference
5  [PMID:8002948]
  Authors
Junker F, Field JA, Bangerter F, Ramsteiner K, Kohler HP, Joannou CL, Mason JR, Leisinger T, Cook AM.
  Title
Oxygenation and spontaneous deamination of 2-aminobenzenesulphonic acid in Alcaligenes sp. strain O-1 with subsequent meta ring cleavage and spontaneous desulphonation to 2-hydroxymuconic acid.
  Journal
Biochem. J. 300 ( Pt 2) (1994) 429-36.
  Organism
Alcaligenes sp.
Reference
6  [PMID:8075807]
  Authors
Junker F, Leisinger T, Cook AM.
  Title
3-Sulphocatechol 2,3-dioxygenase and other dioxygenases (EC 1.13.11.2 and EC 1.14.12.-) in the degradative pathways of 2-aminobenzenesulphonic, benzenesulphonic and 4-toluenesulphonic acids in Alcaligenes sp. strain O-1.
  Journal
Microbiology. 140 ( Pt 7) (1994) 1713-22.
  Organism
Alcaligenes sp.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
9029-46-3

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