KEGG   ENZYME: 1.13.11.2Help
Entry
EC 1.13.11.2                Enzyme                                 

Name
catechol 2,3-dioxygenase;
2,3-pyrocatechase;
catechol 2,3-oxygenase;
catechol oxygenase;
metapyrocatechase;
pyrocatechol 2,3-dioxygenase;
xylE (gene name);
catechol:oxygen 2,3-oxidoreductase (decyclizing)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
catechol:oxygen 2,3-oxidoreductase (ring-opening)
Reaction(IUBMB)
catechol + O2 = 2-hydroxymuconate-6-semialdehyde [RN:R00816]
Reaction(KEGG)
Substrate
catechol [CPD:C00090];
O2 [CPD:C00007]
Product
2-hydroxymuconate-6-semialdehyde [CPD:C00682]
Comment
Requires FeII. The enzyme initiates the meta-cleavage pathway of catechol degradation.
History
EC 1.13.11.2 created 1965 as EC 1.13.1.2, transferred 1972 to EC 1.13.11.2, modified 1999, modified 2013
Pathway
ec00361  Chlorocyclohexane and chlorobenzene degradation
ec00362  Benzoate degradation
ec00622  Xylene degradation
ec00643  Styrene degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00446  catechol 2,3-dioxygenase
K07104  catechol 2,3-dioxygenase
Genes
KMI: VW41_14200
ROR: RORB6_06585
RPLN: B1209_13675
PGE: LG71_12250
EBF: D782_1283
SLQ: M495_12060
PAO: Pat9b_1857 Pat9b_4565
KLN: LH22_12850
PSD: DSC_04410 DSC_09025 DSC_09150
PPJ: RK21_04240
AVN: Avin_08720(xylE) Avin_08800(dmpB) Avin_30770(lapB)
AVL: AvCA_08720(xylE) AvCA_08800(dmpB) AvCA_30770(lapB)
AVD: AvCA6_08720(xylE) AvCA6_08800(dmpB) AvCA6_30770(lapB)
ACX: Achr_32720(xylE)
CYQ: Q91_0505(xylE)
CZA: CYCME_2106(xylE) CYCME_2113(xylE2)
SLIM: SCL_0224
SVA: SVA_1031
TBN: TBH_C0912
RPI: Rpic_4624
REH: H16_B0546(h16_B0546)
CNC: CNE_2c04920(dmpB)
RME: Rmet_1324(dmpB)
BCEN: DM39_4837
BCT: GEM_5406
BCED: DM42_4996
BCON: NL30_24615
BTEI: WS51_00545
BPSL: WS57_12180
BPAR: BN117_4316
BBR: BB4770
VEI: Veis_2789
LCH: Lcho_3356
AZO: azo1844(lapB1) azo1858(xylE) azo2438(lapB2)
ARC: ABLL_2447
MLO: mlr0078
SME: SMc00115
SMER: DU99_05090
SMD: Smed_0602
SFD: USDA257_c07170(catE)
SAME: SAMCFNEI73_Ch1058(catE)
AVI: Avi_1264
RLG: Rleg_0993
BMEL: DK63_296 DK63_3109(hpaD)
BMEE: DK62_2290(hpaD) DK62_563
BABO: DK55_3066(hpaD) DK55_860
BABR: DO74_1029 DO74_2487(hpaD)
BABT: DK49_3162(hpaD) DK49_618
BABB: DK48_1258 DK48_2731(hpaD)
BABU: DK53_3175(hpaD) DK53_844
BABS: DK51_2657(hpaD) DK51_614
BABC: DO78_2982(hpaD) DO78_765
BMS: BR0848
BOV: BOV_0840
BCAS: DA85_04030
BMR: BMI_I845 BMI_II1166(hpaD)
BPP: BPI_I884 BPI_II1221(hpaD)
BPV: DK65_2498(hpaD) DK65_522
OAN: Oant_2378
OAH: DR92_1838
BRA: BRADO3455
AOL: S58_40430
RPA: RPA3761
RPD: RPD_3592
RPT: Rpal_4282
NHA: Nham_3678
OCA: OCAR_4634
VGO: GJW-30_1_02263(catE) GJW-30_1_03332(bphC)
XAU: Xaut_1199
AZC: AZC_2053
SNO: Snov_2993
MEX: Mext_4060
MCH: Mchl_4428
MET: M446_4513
MPO: Mpop_4542
MNO: Mnod_5141
META: Y590_20230
MSL: Msil_1474
HDN: Hden_1713
MMED: Mame_00147(bphC_1)
HDI: HDIA_3050(catE)
SIL: SPO0391(bphC3) SPO3688
PDE: Pden_2379
KRO: BVG79_00675(catE) BVG79_02020(catE)
PGA: PGA1_c32210(hpaD)
PGL: PGA2_c00490(hpaD)
PGD: Gal_00027
PHP: PhaeoP97_03880(hpaD)
PPIC: PhaeoP14_00027(hpaD)
PTP: RCA23_c08430(xylE) RCA23_c25360(hpaD)
CID: P73_0353
RMM: ROSMUCSMR3_02153(catE)
LVS: LOKVESSMR4R_02769(catE)
NAR: Saro_3857
SJP: SJA_C1-11960(xylE)
SINB: SIDU_08285
ASZ: ASN_1357(hpaD)
ATO: CIW82_05280(hpaD)
MAGQ: MGMAQ_0646
MAI: MICA_1707
MAN: A11S_1630
BSU: BSU08240(catE)
BSR: I33_0929
BSL: A7A1_0594
BSH: BSU6051_08240(catE)
BSUT: BSUB_00899(catE)
BSUL: BSUA_00899(catE)
BSUS: Q433_04635
BSS: BSUW23_04175(catE)
BST: GYO_1092
BSO: BSNT_07204(yfiE)
BSQ: B657_08240(catE)
BSX: C663_0846
BLI: BL03021(yfiE)
BLD: BLi00862(catE)
BLH: BaLi_c09660(catE)
BAY: RBAM_008430(yfiE)
BAQ: BACAU_0818(yfiE)
BYA: BANAU_0761(yfiE)
BAMP: B938_04050
BAML: BAM5036_0753(catE)
BAMA: RBAU_0817(catE)
BAMN: BASU_0793(catE)
BAMT: AJ82_04700
BAMY: V529_07860
BMP: NG74_00839(catE)
BAO: BAMF_0794(catE)
BAZ: BAMTA208_03815(yfiE)
BQL: LL3_00850
BXH: BAXH7_00797(yfiE)
BQY: MUS_0847(yfiE)
BAMI: KSO_015600
BAMC: U471_08290
BAMF: U722_04200
BATR: TD68_01305
BHA: BH3305
BAN: BA_3587
BAR: GBAA_3587
BAI: BAA_3616
BANV: DJ46_2307(catE) DJ46_3264(catE)
BTG: BTB_c36050(catE1) BTB_c45000(catE2)
BTW: BF38_114 BF38_4686(catE)
BWW: bwei_0579(catE2) bwei_1409(catE1)
BMYC: DJ92_1457
BMYO: BG05_1666 BG05_2481(catE)
BCL: ABC0839
BPU: BPUM_3530
BPUM: BW16_18710
BPUS: UP12_18120
BMQ: BMQ_3977
BMD: BMD_3962
BMEG: BG04_893
BJS: MY9_0915
BMET: BMMGA3_14555(catE)
BACW: QR42_17685
BACP: SB24_05705
BACB: OY17_06860
BACY: QF06_02995
BACL: BS34A_09210(catE)
BALM: BsLM_0860
BGY: BGLY_0880(yfiE)
BKW: BkAM31D_08390(bphC) BkAM31D_10420(catE)
BBEV: BBEV_2509(catE)
OIH: OB0442
AXL: AXY_05410
LSP: Bsph_0359
HHD: HBHAL_4350(catE)
VPN: A21D_00778(catE)
BSE: Bsel_2931
SAS: SAS1128
SCAP: AYP1020_0502(catE_1) AYP1020_1676(catE_2)
SAGQ: EP23_00120
MCL: MCCL_1717
MCAK: MCCS_22190(catE)
LMO: lmo0646
LMS: LMLG_0615
LMQ: LMM7_0675
LMP: MUO_03530
LMOG: BN389_06850(catE)
LMOE: BN418_0748
LMOB: BN419_0752
LMOD: LMON_0650
LMOW: AX10_11765
LMOX: AX24_00535
LMOQ: LM6179_0956(catE)
LMR: LMR479A_0662(catE)
LMOK: CQ02_03470
LMOM: IJ09_07110
LIN: lin0649
LWE: lwe0613
LSG: lse_0562
LIV: LIV_0592
ESI: Exig_0283
EAN: Eab7_0265
PPY: PPE_02443
PPM: PPSC2_13095(yfiE)
PPO: PPM_2510(yfiE)
PPOL: X809_29390
PPOY: RE92_23700
PMW: B2K_34140
PLV: ERIC2_c02770(catE)
PRI: PRIO_2800(catE)
ASOC: CB4_02445(xylE_1) CB4_02448(xylE_2)
AAC: Aaci_1615
AAD: TC41_1510
JEO: JMA_05400
LLK: LLKF_0912
LLC: LACR_0982
LLR: llh_8115
LLW: kw2_0880
LLJ: LG36_1441
LGR: LCGT_1490
LGV: LCGL_1512
SPY: SPy_2103
SPS: SPs1786
SPYA: A20_1832
SPYH: L897_08885
SPN: SP_0073
SPD: SPD_0072
SPR: spr0066
SPW: SPCG_0068
SPX: SPG_0076
SPV: SPH_0173
SJJ: SPJ_0097
SPP: SPP_0131
SNT: SPT_0104
SNP: SPAP_0118
SND: MYY_0141
SPNN: T308_00265
SAG: SAG2080
SAN: gbs2035
SAK: SAK_2019
SGC: A964_1926
SAGM: BSA_20680
SAGI: MSA_21360
SAGR: SAIL_20840
SAGP: V193_08950
SAGC: DN94_08950
SAGE: EN72_10880
SAGG: EN73_09950
SAGN: W903_1984
STC: str1365
STL: stu1365
STE: STER_1320
STN: STND_1290
STW: Y1U_C1264
STHE: T303_07650
SSA: SSA_1584
SSUT: TL13_1468
SUB: SUB1766
SDA: GGS_1904
SDC: SDSE_2173
SMB: smi_0556
SOR: SOR_0064
STK: STP_1780
LCA: LSEI_1151
LPAP: LBPC_1075
LCS: LCBD_1350
LCE: LC2W_1318
LRH: LGG_01166
LRG: LRHM_1113
LRA: LRHK_1158
EFM: M7W_2338
EHR: EHR_02140
EMU: EMQU_2386
EDU: LIU_04025
MPS: MPTP_1552
MPX: MPD5_0494
THL: TEH_01480
LKI: LKI_04000
CRN: CAR_c17130(catE)
CML: BN424_770
CARC: NY10_1097
AMT: Amet_4725
ERH: ERH_0031
ACL: ACL_0164
ABRA: BN85305000
APAL: BN85412800
CGL: NCgl2007(Cgl2088)
CGB: cg2290
CGU: WA5_2007
CGT: cgR_1972
CGM: cgp_2290
CGJ: AR0_09850
CEF: CE1988
NFA: NFA_30490
NFR: ERS450000_01016(bphC_3)
GBR: Gbro_0240
SMA: SAVERM_1615(xylE)
SLE: sle_08610(sle_08610)
SMAL: SMALA_7911
CMI: CMM_1706
CMS: CMS1950
CMC: CMN_01686
ART: Arth_2485
ARM: ART_1171
AAU: AAur_2454
KRH: KRH_19920
BCV: Bcav_0474
JDE: Jden_0306
XCE: Xcel_0337
IDO: I598_1481(catE) I598_2451(bphC)
CFL: Cfla_3202
SERJ: SGUI_0465
BLIN: BLSMQ_1378
MGG: MPLG2_2486(catE)
NDA: Ndas_2714
TCU: Tcur_0529
BSD: BLASA_2606(pheB)
MMAR: MODMU_2827(pheB)
KAL: KALB_4088
AFS: AFR_28660
CWO: Cwoe_4849
HAU: Haur_0813
TRA: Trad_1134
TTR: Tter_0668
OTE: Oter_2282
OBG: Verru16b_00391(catE)
PBOR: BSF38_05427(catE)
ABAC: LuPra_00214(catE)
GAU: GAU_2905
GBA: J421_0823
PMUC: ING2E5A_2605(catE)
PSAC: PSM36_1787
RMR: Rmar_2383
MUC: MuYL_1370
MGOT: MgSA37_01281(catE)
DFE: Dfer_0290
FAE: FAES_5291
GFO: GFO_2201
GFL: GRFL_2775
MARM: YQ22_04875
AALG: AREALGSMS7_00342(catE)
IAL: IALB_2860
NDE: NIDE0016
NJA: NSJP_1018
SRG: XF24_00871(catE)
HHB: Hhub_1388
HALH: HTSR_0290
HHSR: HSR6_0276
HHI: HAH_1766
HTI: HTIA_1855
HVO: HVO_0425
HME: HFX_0391
HLA: Hlac_0509
NMG: Nmag_3698
NAT: NJ7G_3974
SALI: L593_07315
ACJ: ACAM_1586
SAI: Saci_2295(xylE)
SID: M164_0415
SIC: SiL_0743
PAI: PAE2685
PAS: Pars_0551
PYR: P186_1887
NEV: NTE_00592
TAA: NMY3_01210(catE_1) NMY3_01804(catE_2)
 » show all
Taxonomy
Reference
1
  Authors
Hayaishi, O.
  Title
Direct oxygenation by O2, oxygenases.
  Journal
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 8, Academic Press, New York, 1963, p. 353-371.
Reference
2  [PMID:13757654]
  Authors
KOJIMA Y, ITADA N, HAYAISHI O.
  Title
Metapyrocatachase: a new catechol-cleaving enzyme.
  Journal
J. Biol. Chem. 236 (1961) 2223-8.
Reference
3  [PMID:14087325]
  Authors
NOZAKI M, KAGAMIYAMA H, HAYAISHI O.
  Title
METAPYROCATECHASE. I. PURIFICATION, CRYSTALLIZATION AND SOME PROPERTIES.
  Journal
Biochem. Z. 338 (1963) 582-90.
Reference
4  [PMID:6826545]
  Authors
Nakai C, Hori K, Kagamiyama H, Nakazawa T, Nozaki M
  Title
Purification, subunit structure, and partial amino acid sequence of metapyrocatechase.
  Journal
J. Biol. Chem. 258 (1983) 2916-22.
Reference
5  [PMID:8002948]
  Authors
Junker F, Field JA, Bangerter F, Ramsteiner K, Kohler HP, Joannou CL, Mason JR, Leisinger T, Cook AM.
  Title
Oxygenation and spontaneous deamination of 2-aminobenzenesulphonic acid in Alcaligenes sp. strain O-1 with subsequent meta ring cleavage and spontaneous desulphonation to 2-hydroxymuconic acid.
  Journal
Biochem. J. 300 ( Pt 2) (1994) 429-36.
Reference
6  [PMID:8075807]
  Authors
Junker F, Leisinger T, Cook AM.
  Title
3-Sulphocatechol 2,3-dioxygenase and other dioxygenases (EC 1.13.11.2 and EC 1.14.12.-) in the degradative pathways of 2-aminobenzenesulphonic, benzenesulphonic and 4-toluenesulphonic acids in Alcaligenes sp. strain O-1.
  Journal
Microbiology. 140 ( Pt 7) (1994) 1713-22.
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.2
IUBMB Enzyme Nomenclature: 1.13.11.2
ExPASy - ENZYME nomenclature database: 1.13.11.2
UM-BBD (Biocatalysis/Biodegradation Database): 1.13.11.2
BRENDA, the Enzyme Database: 1.13.11.2
CAS: 9029-46-3

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