| Entry |
|
|---|
| Name |
catechol 2,3-dioxygenase;
2,3-pyrocatechase;
catechol 2,3-oxygenase;
catechol oxygenase;
metapyrocatechase;
pyrocatechol 2,3-dioxygenase |
|---|
| Class |
Oxidoreductases;
Acting on single donors with O2 as oxidant and incorporation of
oxygen into the substrate (oxygenases). The oxygen incorporated need
not be derived from O2;
With incorporation of two atoms of oxygen
 |
|---|
| Sysname |
catechol:oxygen 2,3-oxidoreductase (decyclizing) |
|---|
| Reaction(IUBMB) |
catechol + O2 = 2-hydroxymuconate semialdehyde [RN:R00816] |
|---|
| Reaction(KEGG) |
R00816;
(other) R04089 R05295 R05404 R05406 R07795
 |
|---|
| Substrate |
catechol [CPD:C00090];
O2 [CPD:C00007] |
|---|
| Product |
2-hydroxymuconate semialdehyde [CPD:C00682] |
|---|
| Cofactor |
Iron [CPD:C00023] |
|---|
| Comment |
Requires FeII. The enzyme from Alcaligenes sp. strain O-1 has also
been shown to catalyse the reaction: 2,3-dihydroxybenzenesulfonate +
O2 + H2O = 2-hydroxymuconate + bisulfite and has been referred to as
2,3-dihydroxybenzenesulfonate 2,3-dioxygenase. Further work will be
necessary to show whether or not this is a distinct enzyme. |
|---|
| Pathway |
PATH: ec00362 Benzoate degradation via hydroxylation
PATH: ec00622 Toluene and xylene degradation
PATH: ec00627 1,4-Dichlorobenzene degradation
PATH: ec00629 Carbazole degradation
PATH: ec00643 Styrene degradation
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00446 catechol 2,3-dioxygenase |
|---|
| Genes |
RPI: Rpic_4624
RPF: Rpic12D_3548
REU: Reut_A1133 Reut_B4677 Reut_B5687 Reut_C6234
REH: H16_B0546
RME: Rmet_1324
BVI: Bcep1808_7600
BUR: Bcep18194_B1114 Bcep18194_B1182 Bcep18194_B2964 Bcep18194_C7651
AJS: Ajs_0214 Ajs_0218
VEI: Veis_2789
MPT: Mpe_A2277 Mpe_A3311
AZO: azo1844(lapB1) azo1858(xylE) azo2438(lapB2)
DAR: Daro_3805
RLE: RL2852
BMB: BruAb2_1096
BJA: bll2967 blr3819
BRA: BRADO5115
BBT: BBta_5584
RPA: RPA3761
RPB: RPB_1705
RPD: RPD_3592
SIT: TM1040_3467
RSP: RSP_3021
RSH: Rsph17029_3747
JAN: Jann_3502
NFA: nfa30490
RHA: RHA1_ro03865 RHA1_ro08079
ROP: ROP_53870
ART: Arth_3523
RXY: Rxyl_0199 Rxyl_2243
RRS: RoseRS_2570
RCA: Rcas_2413
CAU: Caur_1348
CAG: Cagg_2031
CHL: Chy400_1470
TRO: trd_0322
DGE: Dgeo_2419
TTJ: TTHB250
SSO: SSO1223 SSO2054
STO: ST0724
SAI: Saci_2295(xylE)
SIS: LS215_0417
SID: M164_0415
SIN: YN1551_2660
MSE: Msed_0995 Msed_1775
 |
|---|
| Structures |
PDB: 1MPY 3HPV 3HPY 3HQ0 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:8002948]
Junker F, Field JA, Bangerter F, Ramsteiner K, Kohler HP, Joannou
CL, Mason JR, Leisinger T, Cook AM.
Oxygenation and spontaneous deamination of 2-aminobenzenesulphonic
acid in Alcaligenes sp. strain O-1 with subsequent meta ring
cleavage and spontaneous desulphonation to 2-hydroxymuconic acid.
Biochem. J. 300 ( Pt 2) (1994) 429-36.
Alcaligenes sp. |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:8075807]
Junker F, Leisinger T, Cook AM.
3-Sulphocatechol 2,3-dioxygenase and other dioxygenases (EC
1.13.11.2 and EC 1.14.12.-) in the degradative pathways of
2-aminobenzenesulphonic, benzenesulphonic and 4-toluenesulphonic
acids in Alcaligenes sp. strain O-1.
Microbiology. 140 ( Pt 7) (1994) 1713-22.
Alcaligenes sp. |
|---|
Reference
Authors
Title
Journal
|
3
Hayaishi, O.
Direct oxygenation by O2, oxygenases.
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd
ed., vol. 8, Academic Press, New York, 1963, p. 353-371. |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:13757654]
KOJIMA Y, ITADA N, HAYAISHI O.
Metapyrocatachase: a new catechol-cleaving enzyme.
J. Biol. Chem. 236 (1961) 2223-8.
Pseudomonas sp. |
|---|
Reference
Authors
Title
Journal
Organism
|
5 [PMID:14087325]
NOZAKI M, KAGAMIYAMA H, HAYAISHI O.
METAPYROCATECHASE. I. PURIFICATION, CRYSTALLIZATION AND SOME
PROPERTIES.
Biochem. Z. 338 (1963) 582-90.
Pseudomonas arvilla |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.13.11.2
IUBMB Enzyme Nomenclature: 1.13.11.2
ExPASy - ENZYME nomenclature database: 1.13.11.2
UM-BBD (Biocatalysis/Biodegradation Database): 1.13.11.2
BRENDA, the Enzyme Database: 1.13.11.2
CAS: 9029-46-3 |
|---|
