KEGG   ENZYME: 1.13.11.24Help
Entry
EC 1.13.11.24               Enzyme                                 

Name
quercetin 2,3-dioxygenase;
quercetinase;
flavonol 2,4-oxygenase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
quercetin:oxygen 2,3-oxidoreductase (decyclizing)
Reaction(IUBMB)
quercetin + O2 = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO + H+ [RN:R02156]
Reaction(KEGG)
Substrate
quercetin [CPD:C00389];
O2 [CPD:C00007]
Product
2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate [CPD:C04524];
CO [CPD:C00237];
H+ [CPD:C00080]
Comment
The enzyme from Aspergillus sp. is a copper protein whereas that from Bacillus subtilis contains iron. Quercetin is a flavonol (5,7,3',4'-tetrahydroxyflavonol).
History
EC 1.13.11.24 created 1972
Orthology
K07155  
quercetin 2,3-dioxygenase
Genes
HEL: 
HELO_2888(yxaG)
BSU: 
BSU39980(qodI)
BSR: 
BSL: 
BSS: 
BST: 
BSN: 
BSQ: 
BSUB: 
BAE: 
BPU: 
BPUM_0236(yxaG)
BJS: 
PMS: 
PMQ: 
PMW: 
RHA: 
ROP: 
SLI: 
 » show all
Taxonomy
Reference
1  [PMID:5579942]
  Authors
Oka T, Simpson FJ.
  Title
Quercetinase, a dioxygenase containing copper.
  Journal
Biochem. Biophys. Res. Commun. 43 (1971) 1-5.
Reference
2  [PMID:12486225]
  Authors
Steiner RA, Kalk KH, Dijkstra BW.
  Title
Anaerobic enzyme.substrate structures provide insight into the reaction mechanism of the copper-dependent quercetin 2,3-dioxygenase.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 16625-30.
  Sequence
[up:Q7SIC2]
Reference
3  [PMID:14741339]
  Authors
Bowater L, Fairhurst SA, Just VJ, Bornemann S.
  Title
Bacillus subtilis YxaG is a novel Fe-containing quercetin 2,3-dioxygenase.
  Journal
FEBS. Lett. 557 (2004) 45-8.
  Sequence
[bsu:BSU39980]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
9075-67-6

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