KEGG   ENZYME: 1.13.11.27Help
Entry
EC 1.13.11.27               Enzyme                                 
Name 4-hydroxyphenylpyruvate dioxygenase;
p-hydroxyphenylpyruvic hydroxylase;
p-hydroxyphenylpyruvate hydroxylase;
p-hydroxyphenylpyruvate oxidase;
p-hydroxyphenylpyruvic oxidase;
p-hydroxyphenylpyruvate dioxygenase;
p-hydroxyphenylpyruvic acid hydroxylase;
4-hydroxyphenylpyruvic acid dioxygenase
Class Oxidoreductases;
Acting on single donors with O2 as oxidant and incorporation of
oxygen into the substrate (oxygenases). The oxygen incorporated need
not be derived from O2;
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname 4-hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating,
decarboxylating)
Reaction(IUBMB) 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2 [RN:R02521]
Reaction(KEGG) R02521;
(other) R01372
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Substrate 4-hydroxyphenylpyruvate [CPD:C01179];
O2 [CPD:C00007]
Product homogentisate [CPD:C00544];
CO2 [CPD:C00011]
Comment The Pseudomonas enzyme contains one Fe3+ per mole of enzyme; the
enzymes from other sources may contain essential iron or copper.
Pathway PATH: ec00130  Ubiquinone and other terpenoid-quinone biosynthesis
PATH: ec00350  Tyrosine metabolism
PATH: ec00360  Phenylalanine metabolism
PATH: ec01100  Metabolic pathways
Orthology KO: K00457  4-hydroxyphenylpyruvate dioxygenase
Genes HSA: 3242(HPD)
PTR: 473296(HPD)
MCC: 700940(HPD)
MMU: 15445(Hpd)
RNO: 29531(Hpd)
CFA: 610778(HPD)
BTA: 516058(HPD)
SSC: 397443(HPD)
ECB: 100059853
MDO: 100021685
OAA: 100074573
GGA: 416852(HPD)
TGU: 100224777
XLA: 100037181 398893 495029
XTR: 594976(hpd) 779829(MGC146689)
DRE: 394142 445287(hpd)
BFO: BRAFLDRAFT_282735
CIN: 100185199
SPU: 594130
DME: Dmel_CG11796
DPO: Dpse_GA11203
DAN: Dana_GF24132
DER: Dere_GG13309
DPE: Dper_GL12777
DSE: Dsec_GM22213
DSI: Dsim_GD12185
DYA: Dyak_GE22742
DGR: Dgri_GH17018
DMO: Dmoj_GI11911
AGA: AgaP_AGAP004802
AAG: AaeL_AAEL010442 AaeL_AAEL014600
CQU: CpipJ_CPIJ004417
AME: 725400
NVI: 100116430
TCA: 662658
ISC: IscW_ISCW018238
CEL: T21C12.2(hpd-1)
CBR: CBG18361
BMY: Bm1_32410
SMM: Smp_007960
HMG: 100200033
TAD: TRIADDRAFT_64341
ATH: AT1G06570(PDS1)
POP: POPTR_798588
RCU: RCOM_1192240
VVI: 100248785
OSA: 4328425(Os02g0168100)
SBI: SORBI_04g004560(SORBIDRAFT_04g004560)
ZMA: 606444(hppd1)
PPP: PHYPADRAFT_178418 PHYPADRAFT_204526
CRE: CHLREDRAFT_137761(HPD2)
OLU: OSTLU_45212
CME: CMI063C
DHA: DEHA0F02156g
PIC: PICST_46345(HPD1)
PPA: PAS_chr4_0335
CAL: CaO19.12954(HPD99)
CTP: CTRG_01779
CDU: CD36_20740
YLI: YALI0B21846g
NCR: NCU01830
PAN: PODANSg2394 PODANSg6688
MGR: MGG_06691 MGG_07780
FGR: FG05703.1 FG06001.1
ANI: AN1140.2 AN1899.2
AFM: AFUA_1G11560 AFUA_2G04200 AFUA_4G10620
AOR: AO090003000208 AO090038000266
ANG: An04g01280 An07g01900 An08g03840 An11g02200
AFV: AFLA_036110 AFLA_068160
PCS: Pc12g09060 Pc12g13180 Pc13g08330 Pc22g07130
NFI: NFIA_013980 NFIA_080990 NFIA_105460
CIM: CIMG_01310
URE: UREG_00277 UREG_01236 UREG_05130
SSL: SS1G_07630
BFU: BC1G_02972
MBR: MONBRDRAFT_32271
DDI: DDB_0231604(hpd)
TET: TTHERM_00678260
PTM: GSPATT00000389001 GSPATT00003696001
TPS: THAPSDRAFT_32153(HDP1)
ETA: ETA_15010
ESA: ESA_01077
CTU: Ctu_28300
KPN: KPN_02130
KPE: KPK_2193
KPU: KP1_3225
DDA: Dd703_4023
DDC: Dd586_4206
DZE: Dd1591_4234
XCC: XCC0436
XCB: XC_0450
XCA: xccb100_0470(hpd)
XCV: XCV0482
XAC: XAC0452
XOO: XOO4071
XOM: XOO_3846
XOP: PXO_04216(hppD)
SML: Smlt4330
SMT: Smal_3739
VCH: VC1344
VCO: VC0395_A0960(hppD)
VCM: VCM66_1299(hppD)
VCJ: VCD_002995
VVU: VV1_2768
VVY: VV1495
VPA: VP1349
VHA: VIBHAR_02177
VSP: VS_II1521
VEX: VEA_003655
PPR: PBPRB1180
PAE: PA0242 PA0865(hpd)
PAU: PA14_03000 PA14_53070(hpd)
PAP: PSPA7_0327 PSPA7_4652(hppD)
PAG: PLES_02391 PLES_44511(hpd)
PPU: PP_2554 PP_3433(hpd)
PPF: Pput_2329 Pput_3161
PPG: PputGB1_2502 PputGB1_3362
PPW: PputW619_2225 PputW619_2440
PST: PSPTO_2346 PSPTO_3553(hppD)
PSB: Psyr_2130 Psyr_3330
PSP: PSPPH_2105 PSPPH_3250(hppD)
PFL: PFL_3387(hppD) PFL_5385
PFO: Pfl01_2917 Pfl01_4905
PFS: PFLU2997 PFLU5367
PEN: PSEEN2014 PSEEN3054(hpd)
PMY: Pmen_1696
PSA: PST_0200 PST_0869(hpd)
AVN: Avin_34750(hppD) Avin_38100(hppD) Avin_50170(hppD)
PCR: Pcryo_1555
PRW: PsycPRwf_1040
ACB: A1S_3418
ABM: ABSDF3597(hpd)
ABY: ABAYE0064(hpd)
ABC: ACICU_03614
ABN: AB57_3871(hppD)
ABB: ABBFA_000065(hppD)
SON: SO_1962
SDN: Sden_2163
SFR: Sfri_2327
SAZ: Sama_1568
SBL: Sbal_2616
SBM: Shew185_2654
SBN: Sbal195_2729
SBP: Sbal223_1731
SLO: Shew_2155
SPC: Sputcn32_1670
SSE: Ssed_2687
SPL: Spea_1873
SHE: Shewmr4_2292
SHM: Shewmr7_2364
SHN: Shewana3_2482
SHW: Sputw3181_2355
SHL: Shal_2410
SWD: Swoo_1932
SWP: swp_2871
ILO: IL0722
CPS: CPS_3484(hppD)
PHA: PSHAa2168(melA)
PAT: Patl_1125 Patl_2997
AMC: MADE_02541
LPN: lpg2278(hpd)
LPF: lpl2204(lly)
LPP: lpp2232(lly)
LPC: LPC_1747(hpd)
NOC: Noc_1437
HCH: HCH_00955(hppD)
CSA: Csal_0292
MMW: Mmwyl1_2737 Mmwyl1_3913
AHA: AHA_2663(hppD)
ASA: ASA_2519(hppD)
KKO: Kkor_1223 Kkor_1519
CVI: CV_0969(hpd)
RSO: RS02058(RSp1400) RS04776(RSp1347) RS05661(RSp1316) RSc3103
RPI: Rpic_3388 Rpic_4300 Rpic_4305
RPF: Rpic12D_3041 Rpic12D_4410 Rpic12D_4415
REU: Reut_B4501 Reut_B5028 Reut_B5035
REH: H16_B1083(hpd)
RME: Rmet_4925
CTI: RALTA_B0905
BMA: BMA2582(hppD) BMAA0848
BMV: BMASAVP1_1752 BMASAVP1_A0003(hppD-1) BMASAVP1_A3120(hppD-2)
BML: BMA10229_2205 BMA10229_A1975(hppD)
BMN: BMA10247_3528(hppD) BMA10247_A0891
BPS: BPSL3239 BPSS0339
BPM: BURPS1710b_0016(hppD) BURPS1710b_A1894
BPL: BURPS1106A_3845(hppD) BURPS1106A_A0481(hppD)
BPD: BURPS668_3784(hppD) BURPS668_A0577
BPR: GBP346_A3971(hppD)
BTE: BTH_I3106(hppD) BTH_II1222 BTH_II2059
BVI: Bcep1808_0303 Bcep1808_3553 Bcep1808_4921
BUR: Bcep18194_A3420 Bcep18194_B0343 Bcep18194_B1625
BCN: Bcen_2785 Bcen_3062 Bcen_3972
BCH: Bcen2424_0321 Bcen2424_4395 Bcen2424_5305
BCM: Bcenmc03_0301 Bcenmc03_4963 Bcenmc03_5960
BCJ: BCAL0207(hppD) BCAM1522 BCAM2503
BAM: Bamb_0240 Bamb_3806 Bamb_4666
BAC: BamMC406_0248 BamMC406_4274 BamMC406_5194
BMU: Bmul_0223 Bmul_3418 Bmul_4226
BMJ: BMULJ_03040(hppD) BMULJ_04280(hppD) BMULJ_05110(hppD)
BXE: Bxe_A0286 Bxe_B0882 Bxe_B2773
BPH: Bphy_1081 Bphy_2866 Bphy_3887
BPY: Bphyt_3671 Bphyt_4567 Bphyt_6758
BGL: bglu_1g02320 bglu_2g03850 bglu_2g11610
BPE: BP3040(bllY)
BPA: BPP3767(bllY)
BBR: BB4213(bllY)
BPT: Bpet0681(bllY)
BAV: BAV2894(bllY)
POL: Bpro_4213 Bpro_4496
PNA: Pnap_1120 Pnap_1560
AAV: Aave_4191
AJS: Ajs_0520
VEI: Veis_2137
DAC: Daci_4795
DIA: Dtpsy_0536
VAP: Vapar_3320 Vapar_4766
CTT: CtCNB1_3836 CtCNB1_4246
MPT: Mpe_A0346
LCH: Lcho_0418 Lcho_0434 Lcho_2042
AZO: azo1193(hppD)
BBA: Bd3543
ADE: Adeh_3422
ACP: A2cp1_3571
AFW: Anae109_3484
ANK: AnaeK_3503
MXA: MXAN_2786(hppD)
SCL: sce4893(hppD1) sce5979(hppD2)
HOH: Hoch_6297 Hoch_6553
MLO: mll8309
MES: Meso_0782 Meso_2885
SME: SM_b20581 SMc03211
SMD: Smed_2836 Smed_4204
ATU: Atu4529
ATC: AGR_L_678
ARA: Arad_8211(hppD) Arad_8810(hppD)
AVI: Avi_5449(hppD)
RET: RHE_CH01745(ypch00593) RHE_PC00215(ypc00119)
REC: RHECIAT_CH0001826
RLE: RL1863 RL2846 pRL110074
RLT: Rleg2_1406 Rleg2_5952
RLG: Rleg_1510 Rleg_7092
RHI: NGR_b00190 NGR_b22740 NGR_c30010
OAN: Oant_4428
BJA: bll0339 bll1053
BRA: BRADO5592 BRADO6961(hpd)
BBT: BBta_0570(hpd) BBta_6113
RPA: RPA0005(hpd)
RPT: Rpal_0005
AZC: AZC_1454
MET: M446_4755
MNO: Mnod_0122
CCR: CC_2533
CCS: CCNA_02616
CAK: Caul_3653
PZU: PHZ_c2833(hpd)
SIL: SPO1426(hppD)
SIT: TM1040_0582
JAN: Jann_3260
RDE: RD1_1830(hppD)
PDE: Pden_1664
MMR: Mmar10_0336
HNE: HNE_2900(hppD)
HBA: Hbal_2664
NAR: Saro_0597 Saro_1586
SAL: Sala_3119
SWI: Swit_3865
ELI: ELI_06415
RCE: RC1_3343(hppD)
BAN: BA0240(hppD)
BAR: GBAA0240(hppD)
BAA: BA_0807
BAT: BAS0226
BAH: BAMEG_0269(hppD)
BAI: BAA_0267(hppD)
BCE: BC0252
BCA: BCE_0260(hppD)
BCZ: BCZK0215(hppD)
BCR: BCAH187_A0274(hppD)
BCB: BCB4264_A0255(hppD)
BCU: BCAH820_0253(hppD)
BCG: BCG9842_B5070(hppD)
BCQ: BCQ_0256(hppD)
BCX: BCA_0278(hppD)
BCY: Bcer98_0228
BTK: BT9727_0213(hppD)
BTL: BALH_0225(hppD)
BWE: BcerKBAB4_0219
BBE: BBR47_43440
MAB: MAB_0893
CGL: NCgl0407(cgl0422)
CGB: cg0502
CGT: cgR_0493
CEF: CE0441
CKP: ckrop_1827
NFA: nfa50810
RHA: RHA1_ro01367 RHA1_ro02040 RHA1_ro03041(hpd1) RHA1_ro03170(hpd2)
     RHA1_ro05074(hpd3)
RER: RER_38070 RER_50610(hpd)
ROP: ROP_10840 ROP_17120(hpd) ROP_27660(hpd) ROP_51350(hpd)
SCO: SCO2927(SCE19A.27c) SCO3229(SCE63.04)
SMA: SAV_1776 SAV_5149(hpd)
SGR: SGR_4612
ART: Arth_4079
AAU: AAur_4045
ACH: Achl_3855
KSE: Ksed_10550
NCA: Noca_1295
TCU: Tcur_1062
SRO: Sros_6970 Sros_8544
FRA: Francci3_2454
FRE: Franean1_3786
NML: Namu_0528 Namu_4090
KRA: Krad_1477
SEN: SACE_0905(hpd3)
SVI: Svir_31830
AMI: Amir_0705 Amir_4590
STP: Strop_2490 Strop_2727 Strop_4250
SAQ: Sare_2673 Sare_4680
CAI: Caci_1486 Caci_3256
ABA: Acid345_2004
ACA: ACP_3311(hppD)
SUS: Acid_4167
SRU: SRU_1370(hppD)
DFE: Dfer_2107
CPI: Cpin_5420
PHE: Phep_3281
GFO: GFO_3170
FJO: Fjoh_0729
FPS: FP0226(hppD)
FBA: FIC_00444
RBI: RB2501_07840
GAU: GAU_2123
SYN: slr0090(ppd)
SYP: SYNPCC7002_A2710
CYA: CYA_0478
CYB: CYB_0246
MAR: MAE_17410
CYT: cce_1311
CYP: PCC8801_3411
CYC: PCC7424_1807
CYN: Cyan7425_5219
CYH: Cyan8802_2705
GVI: glr3091
ANA: all0771
NPU: Npun_R4104
AVA: Ava_4666
TER: Tery_4182
AMR: AM1_4550(hppD)
CAU: Caur_0806
CAG: Cagg_2744
CHL: Chy400_0872
HAU: Haur_2764
DGE: Dgeo_2375
DDR: Deide_1p01390
PTO: PTO1369
Taxonomy
Structures PDB: 1CJX  1SP9  1SQD  1T47  1TFZ  3ISQ  
Reference
  Authors
  Title


  Journal
  Organism
 1  [PMID:7118918]
Lindstedt S, Rundgren M.
Blue color, metal content, and substrate binding in
4-hydroxyphenylpyruvate dioxygenase from Pseudomonas sp. strain P.
J. 874.
J. Biol. Chem. 257 (1982) 11922-31.
Pseudomonas sp.
Reference
  Authors
  Title

  Journal
  Organism
 2  [PMID:7103516]
Roche PA, Moorehead TJ, Hamilton GA.
Purification and properties of hog liver 4-hydroxyphenylpyruvate
dioxygenase.
Arch. Biochem. Biophys. 216 (1982) 62-73.
Sus scofa [GN:ssc]
Other DBs ExplorEnz - The Enzyme Database: 1.13.11.27
IUBMB Enzyme Nomenclature: 1.13.11.27
ExPASy - ENZYME nomenclature database: 1.13.11.27
UM-BBD (Biocatalysis/Biodegradation Database): 1.13.11.27
BRENDA, the Enzyme Database: 1.13.11.27
CAS: 9029-72-5
DBGET integrated database retrieval system