KEGG   ENZYME: 1.13.11.29Help
Entry
EC 1.13.11.29               Enzyme                                 

Name
stizolobate synthase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
3,4-dihydroxy-L-phenylalanine:oxygen 4,5-oxidoreductase (recyclizing)
Reaction(IUBMB)
L-dopa + O2 = 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde [RN:R02075]
Reaction(KEGG)
R02075;
(other) R04598 R04599
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Substrate
L-dopa [CPD:C00355];
O2 [CPD:C00007]
Product
4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde [CPD:C04796]
Comment
The intermediate product undergoes ring closure and oxidation, with NAD(P)+ as acceptor, to stizolobic acid. The enzyme requires Zn2+.
History
EC 1.13.11.29 created 1978
Pathway
Tyrosine metabolism
Reference
1  [PMID:9285]
  Authors
Saito K, Komamine A.
  Title
Biosynthesis of stizolobinic acid and stizolobic acid in higher plants. An enzyme system(s) catalyzing the conversion of dihydroxyphenylalanine into stizolobinic acid and stizolobic acid from etiolated seedlings of Stizolobium hassjoo.
  Journal
Eur. J. Biochem. 68 (1976) 237-43.
Reference
2  [PMID:624278]
  Authors
Saito K, Komamine A.
  Title
Biosynthesis of stizolobinic acid and stizolobic acid in higher plants.
  Journal
Eur. J. Biochem. 82 (1978) 385-92.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
65979-39-7

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