| Entry |
|
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| Name |
protocatechuate 3,4-dioxygenase;
protocatechuate oxygenase;
protocatechuic acid oxidase;
protocatechuic 3,4-dioxygenase;
protocatechuic 3,4-oxygenase |
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| Class |
Oxidoreductases;
Acting on single donors with O2 as oxidant and incorporation of
oxygen into the substrate (oxygenases). The oxygen incorporated need
not be derived from O2;
With incorporation of two atoms of oxygen
 |
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| Sysname |
protocatechuate:oxygen 3,4-oxidoreductase (decyclizing) |
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| Reaction(IUBMB) |
3,4-dihydroxybenzoate + O2 = 3-carboxy-cis,cis-muconate [RN:R01631] |
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| Reaction(KEGG) |
R01631;
(other) R03549
 |
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| Substrate |
3,4-dihydroxybenzoate [CPD:C00230];
O2 [CPD:C00007] |
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| Product |
3-carboxy-cis,cis-muconate [CPD:C01163] |
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| Cofactor |
Iron [CPD:C00023] |
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| Comment |
Requires Fe3+. |
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| Pathway |
PATH: ec00362 Benzoate degradation via hydroxylation
PATH: ec00623 2,4-Dichlorobenzoate degradation
PATH: ec01100 Metabolic pathways |
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| Orthology |
KO: K00448 protocatechuate 3,4-dioxygenase, alpha subunit
KO: K00449 protocatechuate 3,4-dioxygenase, beta subunit |
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| Genes |
EFE: EFER_1501(pcaG) EFER_1502(pcaH)
KPN: KPN_01948 KPN_01949
KPE: KPK_2400(pcaG) KPK_2401(pcaH)
KPU: KP1_3015 KP1_3016
SPE: Spro_2501 Spro_2502
XCC: XCC0367(pcaH) XCC0368(pcaG)
XCB: XC_0379 XC_0380
XCA: xccb100_0393(pcaH) xccb100_0394(pcaG)
XCV: XCV0381(pcaH) XCV0382(pcaG)
XAC: XAC0367(pcaH) XAC0368(pcaG)
XOO: XOO0482(pcaH) XOO0483(pcaG)
XOM: XOO_0448 XOO_0449
XOP: PXO_02906(pcaH) PXO_02907(pcaG)
VPA: VPA0640
VHA: VIBHAR_05532
VEX: VEA_001576
PAE: PA0153(pcaH) PA0154(pcaG)
PAU: PA14_01900(pcaH) PA14_01910(pcaG)
PAP: PSPA7_0231(pcaH) PSPA7_0232(pcaG)
PAG: PLES_01541(pcaH) PLES_01551(pcaG)
PPU: PP_4655(pcaG) PP_4656(pcaH)
PPF: Pput_4517 Pput_4518
PPG: PputGB1_4650 PputGB1_4651
PPW: PputW619_0780 PputW619_0781
PST: PSPTO_2338(pcaH) PSPTO_2339(pcaG)
PSB: Psyr_2122 Psyr_2123
PSP: PSPPH_2096(pcaH) PSPPH_2097(pcaG)
PFL: PFL_1320(pcaH) PFL_1321(pcaG) PFL_5395(pcaG) PFL_5396(pcaH)
PFO: Pfl01_1270 Pfl01_1271
PFS: PFLU1366(pcaH) PFLU1367(pcaG)
PEN: PSEEN4783(pcaG) PSEEN4784(pcaH)
PMY: Pmen_0474
PSA: PST_1249(pcaH) PST_1250(pcaG)
AVN: Avin_38250(pcaG) Avin_38260(pcaH)
ACI: ACIAD1711(pcaH) ACIAD1712(pcaG)
ACB: A1S_1884 A1S_1885
ABM: ABSDF2016(pcaG) ABSDF2017(pcaH)
ABY: ABAYE1680(pcaH) ABAYE1681(pcaG)
ABC: ACICU_01994 ACICU_01995
ABN: AB57_2218(pcaG) AB57_2219(pcaH)
ABB: ABBFA_001568(pcaH) ABBFA_001569(pcaG)
CSA: Csal_0311 Csal_0312
RSO: RSc1441(pcaH) RSc1442(pcaG)
RPI: Rpic_1318 Rpic_1319
RPF: Rpic12D_1382 Rpic12D_1383
REU: Reut_B5024 Reut_B5025
REH: H16_B2290(pcaG) H16_B2291(pcaH1)
RME: Rmet_4013 Rmet_4014
BMA: BMAA0980(pcaG) BMAA0981(pcaH)
BMV: BMASAVP1_0394(pcaH) BMASAVP1_0395(pcaG)
BML: BMA10229_0244(pcaG) BMA10229_0245(pcaH)
BMN: BMA10247_A1351(pcaH) BMA10247_A1352(pcaG)
BPS: BPSS1300(pcaH) BPSS1301(pcaG)
BPM: BURPS1710b_A0318(pcaH) BURPS1710b_A0319(pcaG)
BPL: BURPS1106A_A1760(pcaH) BURPS1106A_A1761(pcaG)
BPD: BURPS668_A1845(pcaH) BURPS668_A1846(pcaG)
BTE: BTH_II1118 BTH_II1119
BVI: Bcep1808_4739 Bcep1808_4740
BUR: Bcep18194_B1859 Bcep18194_B1860
BCN: Bcen_4195 Bcen_4196
BCH: Bcen2424_4171 Bcen2424_4172
BCM: Bcenmc03_3345 Bcenmc03_3346
BCJ: BCAM1299(pcaG) BCAM1300(pcaH)
BAM: Bamb_3578 Bamb_3579
BAC: BamMC406_4058 BamMC406_4059
BMU: Bmul_4419 Bmul_4420
BMJ: BMULJ_04088(pcaG) BMULJ_04089(pcaH)
BXE: Bxe_B2775 Bxe_B2776
BPH: Bphy_3889 Bphy_3890
BPY: Bphyt_6760 Bphyt_6761
BGL: bglu_2g12060 bglu_2g12070
BPT: Bpet0254(pcaG) Bpet0255(pcaH)
POL: Bpro_0627 Bpro_0628
VAP: Vapar_2786 Vapar_4464 Vapar_4465
LCH: Lcho_0120
TMZ: Tmz1t_1486
APP: CAP2UW1_3206
RTY: RT0384(pcaH)
RCM: A1E_03405
RCO: RC0543
RFE: RF_0617
RAK: A1C_02965
RRI: A1G_03080
RRJ: RrIowa_0649
RMS: RMA_0560
RPK: RPR_05810
RAF: RAF_ORF0505
RBE: RBE_0329
RBO: A1I_06140
WBM: Wbm0631
MLO: mlr7208 mlr7210
MES: Meso_2050 Meso_2051
SME: SM_b20576(pcaG) SM_b20577(pcaH)
SMD: Smed_4208 Smed_4209
ATU: Atu4539(pcaG) Atu4540(pcaH)
ATC: AGR_L_656 AGR_L_658
ARA: Arad_9503(pcaH) Arad_9504(pcaG)
AVI: Avi_6128(pcaH) Avi_6129(pcaG)
RET: RHE_PE00056(pcaG) RHE_PE00057(pcaH)
REC: RHECIAT_PA0000060(pcaG) RHECIAT_PA0000061(pcaHa)
RLE: pRL110086(pcaG) pRL110087(pcaH)
RLT: Rleg2_5941 Rleg2_5942
RLG: Rleg_7079 Rleg_7080
RHI: NGR_b21210(pcaG) NGR_b21220(pcaH)
BME: BMEII0635 BMEII0636
BMI: BMEA_B0619(pcaG)
BMF: BAB2_0595(pcaG) BAB2_0596(pcaH)
BMB: BruAb2_0580(pcaG) BruAb2_0581(pcaH)
BMC: BAbS19_II05570 BAbS19_II05580
BMS: BRA0645(pcaH) BRA0646(pcaG)
BOV: BOV_A0608(pcaG)
BCS: BCAN_B0646(pcaG)
BMR: BMI_II643(pcaG)
OAN: Oant_3727 Oant_3728
BJA: blr0927(pcaH) blr0928(pcaG) blr2333(pcaH) blr2334(pcaG)
XAU: Xaut_2688 Xaut_2689
AZC: AZC_1442 AZC_1443
MET: M446_4651 M446_4652
MNO: Mnod_2086 Mnod_2087
CCR: CC_2408 CC_2409
CCS: CCNA_02491 CCNA_02492
CAK: Caul_3850 Caul_3851
SIL: SPOA0043(pcaG) SPOA0044(pcaH)
SIT: TM1040_0557 TM1040_0558
JAN: Jann_4163 Jann_4164
RDE: RD1_3774(pcaH) RD1_3775(pcaG)
PDE: Pden_3493 Pden_3494
DSH: Dshi_3476(pcaG) Dshi_3477(pcaH)
SWI: Swit_1072 Swit_1073
ACR: Acry_1848 Acry_1849
MPA: MAP2730c(pcaG) MAP2731c(pcaH)
MAV: MAV_3505(pcaG) MAV_3506(pcaH)
MSM: MSMEG_2601(pcaH) MSMEG_2602(pcaG)
MVA: Mvan_0560 Mvan_0561
MGI: Mflv_0529 Mflv_0530
MMC: Mmcs_1698 Mmcs_1699
MKM: Mkms_1726 Mkms_1727
MJL: Mjls_1676 Mjls_1677
CGL: NCgl2314(cgl2397) NCgl2315(cgl2398)
CGB: cg2630(pcaG) cg2631(pcaH)
CGT: cgR_2279 cgR_2280
CEF: CE2300 CE2301
RHA: RHA1_ro01335(pcaH) RHA1_ro01336(pcaG)
RER: RER_52860(pcaH) RER_52870(pcaG)
ROP: ROP_10510(pcaH) ROP_10520(pcaG)
SCO: SCO6699(pcaG) SCO6700(pcaH)
SMA: SAV_1703(pcaH) SAV_1704(pcaG)
ART: Arth_4077 Arth_4078
AAU: AAur_4043(pcaG) AAur_4044(pcaH)
ACH: Achl_3853 Achl_3854
KRH: KRH_06040(pcaH) KRH_06050(pcaG)
TCU: Tcur_3345 Tcur_3346
SRO: Sros_7608 Sros_7609
SEN: SACE_3513(pcaG) SACE_3514(pcaH)
SVI: Svir_13010 Svir_13020
AMI: Amir_5084 Amir_5085
CAI: Caci_4889 Caci_4890
RXY: Rxyl_1580 Rxyl_1581
SUS: Acid_0246 Acid_0247
GFO: GFO_3072
RBI: RB2501_01006
RBA: RB7678(pcxB)
CYC: PCC7424_2988
STI: Sthe_0603 Sthe_0604
DGE: Dgeo_2386 Dgeo_2387
DDR: Deide_1p01320(pcaG) Deide_1p01330(pcaH)
 |
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| Structures |
PDB: 1EO2 1EO9 1EOA 1EOB 1EOC 1YKK 1YKL 1YKM 1YKN 1YKO
1YKP 2BUM 2BUQ 2BUR 2BUT 2BUU 2BUV 2BUW 2BUX 2BUY
2BUZ 2BV0 2PCD 3PCA 3PCB 3PCC 3PCD 3PCE 3PCF 3PCG
3PCH 3PCI 3PCJ 3PCK 3PCL 3PCM 3PCN |
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Reference
Authors
Title
Journal
Organism
|
1 [PMID:4967959]
Fujisawa H, Hayaishi O.
Protocatechuate 3,4-dioxygenase. I. Crystallization and
characterization.
J. Biol. Chem. 243 (1968) 2673-81.
Pseudomonas aeruginosa |
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Reference
Authors
Title
Journal
Organism
|
2 [PMID:13319299]
GROSS SR, GAFFORD RD, TATUM EL.
The metabolism of protocatechuic acid by Neurospora.
J. Biol. Chem. 219 (1956) 781-96.
Neurospora crassa [GN:ncr] |
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Reference
Authors
Title
Journal
Organism
|
3 [PMID:13211618]
STANIER RY, INGRAHAM JL.
Protocatechuic acid oxidase.
J. Biol. Chem. 210 (1954) 799-808.
Pseudomonas fluorescens |
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| Other DBs |
ExplorEnz - The Enzyme Database: 1.13.11.3
IUBMB Enzyme Nomenclature: 1.13.11.3
ExPASy - ENZYME nomenclature database: 1.13.11.3
UM-BBD (Biocatalysis/Biodegradation Database): 1.13.11.3
BRENDA, the Enzyme Database: 1.13.11.3
CAS: 9029-47-4 |
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