| Entry |
|
|---|
| Name |
arachidonate 15-lipoxygenase;
15-lipoxygenase;
linoleic acid omega6-lipoxygenase;
omega6 lipoxygenase |
|---|
| Class |
Oxidoreductases;
Acting on single donors with O2 as oxidant and incorporation of
oxygen into the substrate (oxygenases). The oxygen incorporated need
not be derived from O2;
With incorporation of two atoms of oxygen
 |
|---|
| Sysname |
arachidonate:oxygen 15-oxidoreductase |
|---|
| Reaction(IUBMB) |
arachidonate + O2 =
(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate
[RN:R01593] |
|---|
| Reaction(KEGG) |
R01593;
(other) R03626
 |
|---|
| Substrate |
arachidonate [CPD:C00219];
O2 [CPD:C00007] |
|---|
| Product |
(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate
[CPD:C05966] |
|---|
| Comment |
The product is rapidly reduced to the corresponding 15S-hydroxy
compound. |
|---|
| Pathway |
PATH: ec00590 Arachidonic acid metabolism
PATH: ec00591 Linoleic acid metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00460 arachidonate 15-lipoxygenase
KO: K08022 arachidonate 15-lipoxygenase (second type) /
8-lipoxygenase (S-type) |
|---|
| Genes |
HSA: 246(ALOX15) 247(ALOX15B)
PTR: 455104(ALOX15B) 748294(ALOX15)
MCC: 709212(ALOX15) 716764(ALOX15B)
MMU: 11688(Alox8)
RNO: 266604(Alox15b) 303252(Alox12e) 81639(Alox15)
CFA: 489458(ALOX15) 489485(ALOX15B)
BTA: 282139(ALOX15) 286820(ALOX15B) 787450(ALOX12E)
SSC: 396971(ALOX15)
ECB: 100072900 100073039(ALOX15B)
GGA: 425997(ALOXE3)
DRE: 322732(alox12)
SDN: Sden_1680
BTE: BTH_I2353
NMU: Nmul_A0532
 |
|---|
| Structures |
PDB: 1LOX 2P0M |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:6804460]
Bryant RW, Bailey JM, Schewe T, Rapoport SM.
Positional specificity of a reticulocyte lipoxygenase. Conversion of
arachidonic acid to 15-S-hydroperoxy-eicosatetraenoic acid.
J. Biol. Chem. 257 (1982) 6050-5.
Glycine max |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:6813644]
Narumiya S, Salmon JA.
Arachidonic acid-15-lipoxygenase from rabbit peritoneal
polymorphonuclear leukocytes.
Methods. Enzymol. 86 (1982) 45-8.
Oryctolagus cuniculus |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:2496760]
Oliw EH, Sprecher H.
Metabolism of polyunsaturated fatty acids by an (n - 6)-lipoxygenase
associated with human ejaculates.
Biochim. Biophys. Acta. 1002 (1989) 283-91.
Homo sapiens [GN:hsa] |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:3112136]
Shibata D, Steczko J, Dixon JE, Hermodson M, Yazdanparast R, Axelrod
B.
Primary structure of soybean lipoxygenase-1.
J. Biol. Chem. 262 (1987) 10080-5.
Glycine max |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.13.11.33
IUBMB Enzyme Nomenclature: 1.13.11.33
ExPASy - ENZYME nomenclature database: 1.13.11.33
BRENDA, the Enzyme Database: 1.13.11.33
CAS: 82249-77-2 |
|---|
