| Entry |
|
|---|
| Name |
arachidonate 5-lipoxygenase;
leukotriene-A4 synthase;
Delta5-lipoxygenase;
5Delta-lipoxygenase;
arachidonic 5-lipoxygenase;
arachidonic acid 5-lipoxygenase;
C-5-lipoxygenase;
LTA synthase;
leukotriene A4 synthase |
|---|
| Class |
Oxidoreductases;
Acting on single donors with O2 as oxidant and incorporation of
oxygen into the substrate (oxygenases). The oxygen incorporated need
not be derived from O2;
With incorporation of two atoms of oxygen
 |
|---|
| Sysname |
arachidonate:oxygen 5-oxidoreductase |
|---|
| Reaction(IUBMB) |
(1) arachidonate + O2 =
(5S,6S,7E,9E,11Z,14Z)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O
(overall reaction) [RN:R08527];
(2) (1a) arachidonate + O2 =
(5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoate
[RN:R01595];
(3) (1b) (5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoate
= (5S,6S,7E,9E,11Z,14Z)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O
[RN:R03058] |
|---|
| Reaction(KEGG) |
R01595 R03058 R08527;
(other) R07057
 |
|---|
| Substrate |
arachidonate [CPD:C00219];
O2 [CPD:C00007];
(5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoate
[CPD:C05356] |
|---|
| Product |
(5S,6S,7E,9E,11Z,14Z)-5,6-epoxyicosa-7,9,11,14-tetraenoate
[CPD:C00909];
H2O [CPD:C00001];
(5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoate
[CPD:C05356] |
|---|
| Inhibitor |
AA861 [CPD:C01349];
Caffeate [CPD:C01481];
2-Heptyl-4-hydroxyquinoline-N-oxide [CPD:C04284] |
|---|
| Pathway |
PATH: ec00590 Arachidonic acid metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00461 arachidonate 5-lipoxygenase |
|---|
| Genes |
HSA: 240(ALOX5)
PTR: 450428(ALOX5)
MCC: 707926(ALOX5)
MMU: 11689(Alox5)
RNO: 25290(Alox5)
CFA: 477753(ALOX5)
BTA: 404074(ALOX5)
SSC: 100156205
ECB: 100062042(ALOX5)
MDO: 100013954
DRE: 567204(DKEY-194N13.2)
SPU: 584481
NVE: NEMVE_v1g145353 NEMVE_v1g229180
NEU: NE1239(ALOX5)
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:2829172]
Matsumoto T, Funk CD, Radmark O, Hoog JO, Jornvall H, Samuelsson B.
Molecular cloning and amino acid sequence of human 5-lipoxygenase.
Proc. Natl. Acad. Sci. U. S. A. 85 (1988) 26-30.
Homo sapiens [GN:hsa] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:3038871]
Ohishi N, Izumi T, Minami M, Kitamura S, Seyama Y, Ohkawa S, Terao
S, Yotsumoto H, Takaku F, Shimizu T.
Leukotriene A4 hydrolase in the human lung. Inactivation of the
enzyme with leukotriene A4 isomers.
J. Biol. Chem. 262 (1987) 10200-5.
Homo sapiens [GN:hsa] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:3012557]
Shimizu T, Izumi T, Seyama Y, Tadokoro K, Radmark O, Samuelsson B.
Characterization of leukotriene A4 synthase from murine mast cells:
evidence for its identity to arachidonate 5-lipoxygenase.
Proc. Natl. Acad. Sci. U. S. A. 83 (1986) 4175-9.
Mus musculus [GN:mmu] |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:6322165]
Shimizu T, Radmark O, Samuelsson B.
Enzyme with dual lipoxygenase activities catalyzes leukotriene A4
synthesis from arachidonic acid.
Proc. Natl. Acad. Sci. U. S. A. 81 (1984) 689-93.
Solanum tuberosum |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.13.11.34
IUBMB Enzyme Nomenclature: 1.13.11.34
ExPASy - ENZYME nomenclature database: 1.13.11.34
BRENDA, the Enzyme Database: 1.13.11.34
CAS: 80619-02-9 |
|---|
|
