| Entry |
|
|---|
| Name |
hydroxyquinol 1,2-dioxygenase;
hydroxyquinol dioxygenase |
|---|
| Class |
Oxidoreductases;
Acting on single donors with O2 as oxidant and incorporation of
oxygen into the substrate (oxygenases). The oxygen incorporated need
not be derived from O2;
With incorporation of two atoms of oxygen
 |
|---|
| Sysname |
benzene-1,2,4-triol:oxygen 1,2-oxidoreductase (decyclizing) |
|---|
| Reaction(IUBMB) |
benzene-1,2,4-triol + O2 = 3-hydroxy-cis,cis-muconate [RN:R04061] |
|---|
| Reaction(KEGG) |
R04061;
(other) R03891
 |
|---|
| Substrate |
benzene-1,2,4-triol [CPD:C02814];
O2 [CPD:C00007] |
|---|
| Product |
3-hydroxy-cis,cis-muconate [CPD:C03676] |
|---|
| Cofactor |
Iron [CPD:C00023] |
|---|
| Comment |
An iron protein. The product isomerizes to 2-maleylacetate
(cis-hexenedioate). Highly specific; catechol and pyrogallol are
acted on at less than 1% of the rate at which hydroxyquinol is
oxidized. |
|---|
| Pathway |
PATH: ec00362 Benzoate degradation via hydroxylation
PATH: ec00627 1,4-Dichlorobenzene degradation
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K04098 hydroxyquinol 1,2-dioxygenase |
|---|
| Genes |
DHA: DEHA0F25036g
PIC: PICST_52208(HDQ2) PICST_62287(HQD1)
RPA: RPA2149
MSM: MSMEG_4041 MSMEG_6713
RHA: RHA1_ro11310
 |
|---|
| Structures |
PDB: 1TMX |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:6539772]
Sze IS, Dagley S.
Properties of salicylate hydroxylase and hydroxyquinol
1,2-dioxygenase purified from Trichosporon cutaneum.
J. Bacteriol. 159 (1984) 353-9.
Trichosporon cutaneum |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.13.11.37
IUBMB Enzyme Nomenclature: 1.13.11.37
ExPASy - ENZYME nomenclature database: 1.13.11.37
UM-BBD (Biocatalysis/Biodegradation Database): 1.13.11.37
BRENDA, the Enzyme Database: 1.13.11.37
CAS: 91847-14-2 |
|---|
