| Entry |
|
|---|
| Name |
gentisate 1,2-dioxygenase;
gentisate oxygenase;
2,5-dihydroxybenzoate dioxygenase;
gentisate dioxygenase;
gentisic acid oxidase |
|---|
| Class |
Oxidoreductases;
Acting on single donors with O2 as oxidant and incorporation of
oxygen into the substrate (oxygenases). The oxygen incorporated need
not be derived from O2;
With incorporation of two atoms of oxygen
 |
|---|
| Sysname |
gentisate:oxygen 1,2-oxidoreductase (decyclizing) |
|---|
| Reaction(IUBMB) |
2,5-dihydroxybenzoate + O2 = maleylpyruvate [RN:R02656] |
|---|
| Reaction(KEGG) |
R02656
 |
|---|
| Substrate |
2,5-dihydroxybenzoate [CPD:C00628];
O2 [CPD:C00007] |
|---|
| Product |
maleylpyruvate [CPD:C02167] |
|---|
| Cofactor |
Iron [CPD:C00023] |
|---|
| Comment |
Requires Fe2+. |
|---|
| Pathway |
PATH: ec00350 Tyrosine metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00450 gentisate 1,2-dioxygenase |
|---|
| Genes |
PAN: PODANSg3523
MGR: MGG_10213
FGR: FG04775.1
AOR: AO090005000292
AFV: AFLA_075310
PCS: Pc20g02510
ECE: Z3393
ECS: ECs3030
ECF: ECH74115_3270(gtdA)
ETW: ECSP_3016
ECW: EcE24377A_2433(gtdA)
STY: STY2408
STT: t0677
SPT: SPA0673
SEK: SSPA0632
SPQ: SPAB_00838
SEI: SPC_1524
SEC: SC2195(gdo)
SEH: SeHA_C2413(gtdA)
SEE: SNSL254_A2368(gtdA)
SEW: SeSA_A2417(gtdA)
SEA: SeAg_B2324(gtdA)
SED: SeD_A2525(gtdA)
SEG: SG2214
SET: SEN2171
STM: STM2178
CKO: CKO_00651
SPE: Spro_4624
PAE: PA2470(gtdA)
PAU: PA14_32690(gtdA)
PAP: PSPA7_2768(gtdA)
PAG: PLES_28261(gtdA)
PEN: PSEEN2593(mhbD)
PRW: PsycPRwf_0738
MMW: Mmwyl1_2675
RSO: RSc1087(nagI)
REU: Reut_B5802 Reut_B5864
REH: H16_B0873
BUR: Bcep18194_B1889
BCN: Bcen_4221
BCH: Bcen2424_4145
BCM: Bcenmc03_3374
BCJ: BCAM1271(mhbD)
BMU: Bmul_4442
BMJ: BMULJ_04067(gtdA)
BXE: Bxe_A2627 Bxe_A4526
BPT: Bpet0517
BAV: BAV1782(nagI)
POL: Bpro_0981 Bpro_2125
AAV: Aave_0146
VEI: Veis_4214
DAC: Daci_3702
VAP: Vapar_0353 Vapar_0655
CTT: CtCNB1_2778
LCH: Lcho_0799 Lcho_3670
EBA: ebA1373(nagI) ebA5613(nagI)
AZO: azo2420(nagI)
MES: Meso_0053 Meso_3565
ARA: Arad_7203
BJA: blr0110 blr3412
BRA: BRADO0683
BBT: BBta_3243 BBta_7501
OCA: OCAR_4378
CAK: Caul_5250
SIL: SPO3690(gtdA-1) SPOA0115(gtdA-2)
JAN: Jann_2910
PDE: Pden_0167
HBA: Hbal_2640
SAL: Sala_1387
SWI: Swit_0819 Swit_3059 Swit_5102
BHA: BH2002 BH2004
BCU: BCAH820_3034
GYC: GYMC61_2254 GYMC61_2286 GYMC61_2315
CGL: NCgl2920(cgl3023)
CGB: cg3351(nagI)
CGT: cgR_2910
CEF: CE2860
RHA: RHA1_ro01866
ROP: ROP_15440
ART: Arth_2052
AAU: AAur_0331(gtdA)
SVI: Svir_20700
STR: Sterm_0654
 |
|---|
| Structures |
PDB: 2D40 2PHD 3BU7 |
|---|
Reference
Authors
Title
Journal
|
1
Hayaishi, O.
Direct oxygenation by O2, oxygenases.
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd
ed., vol. 8, Academic Press, New York, 1963, p. 353-371. |
|---|
Reference
Authors
Title
Journal
|
2
Sugiyama, S., Yano, K., Komagata, K. and Arima, K.
Metabolites of aromatic compounds by microbes. Part VII. Gentisic
acid oxidase.
Bull. Agric. Chem. Soc. Jpn 24 (1960) 243-248. |
|---|
Reference
Authors
Title
Journal
|
3
Sugiyama, S., Yano, K. and Arima, K.
Metabolites of aromatic compounds by microbes. Part VII. Further
studies of gentisic acid oxidase.
Bull. Agric. Chem. Soc. Jpn 24 (1960) 249-254. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.13.11.4
IUBMB Enzyme Nomenclature: 1.13.11.4
ExPASy - ENZYME nomenclature database: 1.13.11.4
BRENDA, the Enzyme Database: 1.13.11.4
CAS: 9029-48-5 |
|---|
