| Entry |
|
|---|
| Name |
arachidonate 8-lipoxygenase;
8-lipoxygenase;
8(R)-lipoxygenase |
|---|
| Class |
Oxidoreductases;
Acting on single donors with O2 as oxidant and incorporation of
oxygen into the substrate (oxygenases). The oxygen incorporated need
not be derived from O2;
With incorporation of two atoms of oxygen
 |
|---|
| Sysname |
arachidonate:oxygen 8-oxidoreductase |
|---|
| Reaction(IUBMB) |
arachidonate + O2 =
(5Z,9E,11Z,14Z)-(8R)-8-hydroperoxyicosa-5,9,11,14-tetraenoate
[RN:R01594] |
|---|
| Reaction(KEGG) |
R01594
 |
|---|
| Substrate |
arachidonate [CPD:C00219];
O2 [CPD:C00007] |
|---|
| Product |
(5Z,9E,11Z,14Z)-(8R)-8-hydroperoxyicosa-5,9,11,14-tetraenoate
[CPD:C04822] |
|---|
| Comment |
From the coral Pseudoplexaura porosa. |
|---|
| Pathway |
PATH: ec00590 Arachidonic acid metabolism |
|---|
| Structures |
PDB: 2FNQ 3DY5 3FG1 3FG3 3FG4 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:2867091]
Bundy GL, Nidy EG, Epps DE, Mizsak SA, Wnuk RJ.
Discovery of an arachidonic acid C-8 lipoxygenase in the gorgonian
coral Pseudoplexaura porosa.
J. Biol. Chem. 261 (1986) 747-51.
Pseudoplexaura porosa |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.13.11.40
IUBMB Enzyme Nomenclature: 1.13.11.40
ExPASy - ENZYME nomenclature database: 1.13.11.40
BRENDA, the Enzyme Database: 1.13.11.40
CAS: 100900-72-9 |
|---|
