| Entry |
|
|---|
| Name |
linoleate diol synthase;
linoleate (8R)-dioxygenase |
|---|
| Class |
Oxidoreductases;
Acting on single donors with O2 as oxidant and incorporation of
oxygen into the substrate (oxygenases). The oxygen incorporated need
not be derived from O2;
With incorporation of two atoms of oxygen
 |
|---|
| Sysname |
linoleate:oxygen 7S,8S-oxidoreductase |
|---|
| Reaction(IUBMB) |
linoleate + O2 = (9Z,12Z)-(7S,8S)-dihydroxyoctadeca-9,12-dienoate
[RN:R07061 R07062] |
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| Reaction(KEGG) |
R07061 R07062
 |
|---|
| Substrate |
linoleate [CPD:C01595];
O2 [CPD:C00007] |
|---|
| Product |
(9Z,12Z)-(7S,8S)-dihydroxyoctadeca-9,12-dienoate [CPD:C07354] |
|---|
| Comment |
Oleate and linolenate are also substrates, whereas stearate,
elaidate, gamma-linolenate, arachidonate and icosapentaenate are
not. This enzyme differs from lipoxygenase (EC 1.13.11.12) because
it catalyses the formation of a hydroperoxide without affecting the
double bonds of the substrate. |
|---|
| Pathway |
PATH: ec00591 Linoleic acid metabolism |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:1634517]
Brodowsky ID, Hamberg M, Oliw EH.
A linoleic acid (8R)-dioxygenase and hydroperoxide isomerase of the
fungus Gaeumannomyces graminis. Biosynthesis of (8R)-hydroxylinoleic
acid and (7S,8S)-dihydroxylinoleic acid from
(8R)-hydroperoxylinoleic acid.
J. Biol. Chem. 267 (1992) 14738-45.
Gaeumannomyces graminis |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:8117115]
Hamberg M, Zhang LY, Brodowsky ID, Oliw EH.
Sequential oxygenation of linoleic acid in the fungus Gaeumannomyces
graminis: stereochemistry of dioxygenase and hydroperoxide isomerase
reactions.
Arch. Biochem. Biophys. 309 (1994) 77-80.
Gaeumannomyces graminis |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:10497176]
Hornsten L, Su C, Osbourn AE, Garosi P, Hellman U, Wernstedt C, Oliw
EH.
Cloning of linoleate diol synthase reveals homology with
prostaglandin H synthases.
J. Biol. Chem. 274 (1999) 28219-24.
Gaeumannomyces graminis |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:9778131]
Oliw EH, Su C, Skogstrom T, Benthin G.
Analysis of novel hydroperoxides and other metabolites of oleic,
linoleic, and linolenic acids by liquid chromatography-mass
spectrometry with ion trap MSn.
Lipids. 33 (1998) 843-52.
Gaeumannomyces graminis |
|---|
Reference
Authors
Title
Journal
Organism
|
5 [PMID:8662736]
Su C, Oliw EH.
Purification and characterization of linoleate 8-dioxygenase from
the fungus Gaeumannomyces graminis as a novel hemoprotein.
J. Biol. Chem. 271 (1996) 14112-8.
Gaeumannomyces graminis |
|---|
Reference
Authors
Title
Journal
Organism
|
6 [PMID:9694817]
Su C, Sahlin M, Oliw EH.
A protein radical and ferryl intermediates are generated by
linoleate diol synthase, a ferric hemeprotein with dioxygenase and
hydroperoxide isomerase activities.
J. Biol. Chem. 273 (1998) 20744-51.
Gaeumannomyces graminis |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.13.11.44
IUBMB Enzyme Nomenclature: 1.13.11.44
ExPASy - ENZYME nomenclature database: 1.13.11.44
BRENDA, the Enzyme Database: 1.13.11.44
CAS: 143793-22-0 |
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