KEGG   ENZYME: 1.13.11.47Help
Entry
EC 1.13.11.47               Enzyme                                 

Name
3-hydroxy-4-oxoquinoline 2,4-dioxygenase;
(1H)-3-hydroxy-4-oxoquinoline 2,4-dioxygenase;
3-hydroxy-4-oxo-1,4-dihydroquinoline 2,4-dioxygenase;
3-hydroxy-4(1H)-one, 2,4-dioxygenase;
quinoline-3,4-diol 2,4-dioxygenase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
3-hydroxy-1H-quinolin-4-one 2,4-dioxygenase (CO-forming)
Reaction(IUBMB)
3-hydroxy-1H-quinolin-4-one + O2 = N-formylanthranilate + CO [RN:R05719]
Reaction(KEGG)
R05719;
(other) R04915
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Substrate
3-hydroxy-1H-quinolin-4-one [CPD:C11503];
O2 [CPD:C00007]
Product
N-formylanthranilate [CPD:C05653];
CO [CPD:C00237]
Comment
Does not contain a metal centre or organic cofactor. Fission of two C-C bonds: 2,4-dioxygenolytic cleavage with concomitant release of carbon monoxide. The enzyme from Pseudomonas putida is highly specific for this substrate.
History
EC 1.13.11.47 created 1999 as EC 1.13.99.5, transferred 2001 to EC 1.13.11.47 (EC 1.12.99.5 created 1999 deleted 2001 as identical)
Reference
1
  Authors
Bauer, I., De Beyer, A., Tsisuaka, B., Fetzner, S. and Lingens, F.
  Title
A novel type of oxygenolytic ring cleavage: 2,4-Oxygenation and decarbonylation of 1H-3-hydroxy-4-oxoquinaldine and 1H-3-hydroxy-4-oxoquinoline.
  Journal
FEMS Microbiol. Lett. 117 (1994) 299-304.
Reference
2  [PMID:8856057]
  Authors
Bauer I, Max N, Fetzner S, Lingens F.
  Title
2,4-dioxygenases catalyzing N-heterocyclic-ring cleavage and formation of carbon monoxide. Purification and some properties of 1H-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase from Arthrobacter sp. Ru61a and comparison with 1H-3-hydroxy-4-oxoquinoline 2,4-dioxygenase from Pseudomonas putida 33/1.
  Journal
Eur. J. Biochem. 240 (1996) 576-83.
Reference
3  [PMID:10482514]
  Authors
Fischer F, Kunne S, Fetzner S.
  Title
Bacterial 2,4-dioxygenases: new members of the alpha/beta hydrolase-fold superfamily of enzymes functionally related to serine hydrolases.
  Journal
J. Bacteriol. 181 (1999) 5725-33.
  Sequence
[up:O33472]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
238093-32-8

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