| Entry |
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| Name |
homogentisate 1,2-dioxygenase;
homogentisicase;
homogentisate oxygenase;
homogentisate dioxygenase;
homogentisate oxidase;
homogentisic acid oxidase;
homogentisic acid oxygenase;
homogentisic oxygenase
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| Class |
Oxidoreductases;
Acting on single donors with O2 as oxidant and incorporation of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2;
With incorporation of two atoms of oxygen
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| Sysname |
homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
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| Reaction(IUBMB) |
homogentisate + O2 = 4-maleylacetoacetate [RN: R02519]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
4-maleylacetoacetate [CPD: C01036]
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| Comment |
Requires Fe2+.
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| Pathway |
| Tyrosine metabolism | | Styrene degradation | | Metabolic pathways | | Microbial metabolism in diverse environments |
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| Orthology |
| homogentisate 1,2-dioxygenase |
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| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | MCC: | | MMU: | | RNO: | | CFA: | | AML: | | FCA: | | BTA: | | SSC: | | ECB: | | MDO: | | SHR: | | OAA: | | GGA: | | MGP: | | TGU: | | ACS: | | XLA: | | XTR: | | DRE: | | TRU: | | OLA: | | BFO: | | CIN: | | SPU: | | DME: | | DPO: | | DAN: | | DER: | | DPE: | | DSE: | | DSI: | | DWI: | | DYA: | | DGR: | | DMO: | | DVI: | | AGA: | | AAG: | | CQU: | | NVI: | | TCA: | | PHU: | | ISC: | | CEL: | | CBR: | | NVE: | | HMG: | | TAD: | | ATH: | | ALY: | | GMX: | | CSV: | | RCU: | | POP: | | VVI: | | OSA: | | DOSA: | | BDI: | | SBI: | | ZMA: | | SMO: | | PPP: | | CRE: | | NCR: | | SMP: | | PAN: | | TTT: | | MTM: | | MGR: | | FGR: | | NHE: | | VAL: | | SSL: | | BFU: | | ANI: | | NFI: | | AFM: | | AOR: | | ANG: | | AFV: | | ACT: | | PCS: | | CIM: | | CPW: | | PBL: | | URE: | | ABE: | | TVE: | | AJE: | | PNO: | | PTE: | | ZTR: | | TML: | | MPR: | | CCI: | | UMA: | | MBR: | | NGR: | | DDI: | | DPP: | | TET: | | PTM: | | PTI: | | TPS: | | PIF: | | XCC: | | XCB: | | XCA: | | XCV: | | XCP: | | XAC: | | XAX: | | XAO: | | XOO: | | XOM: | | XOP: | | XOR: | | XAL: | | XCI: | | SML: | | SMT: | | BUJ: | | SMZ: | | PSU: | | PSD: | | RHD: | | VCH: | | VCE: | | VCJ: | | VCO: | | VCR: | | VCM: | | VCI: | | VVU: | | VVY: | | VVM: | | VPA: | | VPB: | | VHA: | | VSP: | | VEX: | | VEJ: | | VFU: | | PPR: | | VAN: | | PAE: | | PAU: | | PAP: | | PAG: | | PAF: | | PNC: | | PDK: | | PSG: | | PPU: | | PPF: | | PPG: | | PPW: | | PPT: | | PPB: | | PPI: | | PPX: | | PPUH: | | PPUU: | | PST: | | PSB: | | PSP: | | PFL: | | PFO: | | PFS: | | PFE: | | PFC: | | PPZ: | | PEN: | | PMY: | | PMK: | | PSA: | | PSZ: | | PSR: | | PSC: | | PSJ: | | PSH: | | PBA: | | PFV: | | PDR: | | AVN: | | AVL: | | AVD: | | SON: | | SDN: | | SFR: | | SAZ: | | SBL: | | SBM: | | SBN: | | SBP: | | SBT: | | SBS: | | SBB: | | SLO: | | SPC: | | SHP: | | SPL: | | SHE: | | SHM: | | SHN: | | SHW: | | SHL: | | SWD: | | SWP: | | SVO: | | ILO: | | PHA: | | PSM: | | AMC: | | AMAC: | | AMB: | | AMG: | | AMK: | | AMAA: | | ALT: | | GAG: | | GPS: | | FBL: | | LPN: | | LPU: | | LPF: | | LPP: | | LPC: | | LPA: | | LPE: | | LLO: | | NOC: | | NHL: | | HCH: | | HEL: | | KKO: | | MMW: | | AHA: | | AVR: | | OCE: | | SAGA: | | CVI: | | PSE: | | RSO: | | RSL: | | RSN: | | RPI: | | RPF: | | REU: | | REH: | | RME: | | CTI: | | CNC: | | BMA: | | BMV: | | BML: | | BMN: | | BPS: | | BPM: | | BPL: | | BPD: | | BPR: | | BPZ: | | BPQ: | | BTE: | | BVI: | | BUR: | | BCN: | | BCH: | | BCM: | | BCJ: | | BAM: | | BAC: | | BMU: | | BMJ: | | BCT: | | BXE: | | BPH: | | BPY: | | BGL: | | BUG: | | BGE: | | BGF: | | BGD: | | BYI: | | BUK: | | BPX: | | BPE: | | BPC: | | BPER: | | BPA: | | BPAR: | | BBR: | | BBM: | | BBH: | | BPT: | | BAV: | | AXY: | | PUT: | | AKA: | | POL: | | VAP: | | VPE: | | MPT: | | HSE: | | CFU: | | LCH: | | BBA: | | BBAT: | | BEX: | | BMX: | | ADE: | | ACP: | | AFW: | | ANK: | | MXA: | | MFU: | | MSD: | | CCX: | | SUR: | | SCL: | | HOH: | | MLO: | | MCI: | | MOP: | | MAM: | | MES: | | SME: | | SMK: | | SMQ: | | SMX: | | SMI: | | SMEG: | | SMEL: | | SMD: | | RHI: | | SFH: | | SFD: | | ARA: | | RET: | | REC: | | RLE: | | RLT: | | RLG: | | BJA: | | BJU: | | BRA: | | BBT: | | BRS: | | RPA: | | RPB: | | RPC: | | RPD: | | RPE: | | RPT: | | RPX: | | NHA: | | AOL: | | XAU: | | MET: | | MPO: | | MNO: | | MSC: | | CCR: | | CCS: | | CAK: | | CSE: | | PZU: | | BSB: | | AEX: | | SIL: | | SIT: | | JAN: | | RDE: | | RLI: | | PDE: | | DSH: | | PSF: | | PGA: | | PGL: | | SWI: | | SPHM: | | SJP: | | SCH: | | RCE: | | AZL: | | ALI: | | TMO: | | APB: | | PGV: | | MAI: | | MAN: | | BAN: | | BAR: | | BAT: | | BAH: | | BAI: | | BAX: | | BAL: | | BCE: | | BCA: | | BCZ: | | BCR: | | BCB: | | BCU: | | BCG: | | BCQ: | | BCX: | | BNC: | | BCF: | | BCER: | | BCY: | | BTK: | | BTL: | | BTB: | | BTT: | | BTC: | | BTF: | | BTM: | | BTG: | | BTI: | | BTN: | | BTHT: | | BWE: | | BBE: | | BTS: | | MAV: | | MIT: | | MIR: | | MIA: | | MID: | | MSM: | | MSG: | | MSA: | | MVA: | | MGI: | | MSP: | | MAB: | | MMV: | | MMC: | | MKM: | | MJL: | | MJD: | | MMI: | | MRH: | | MMM: | | MCB: | | MLI: | | ASD: | | NFA: | | NCY: | | NBR: | | RHA: | | RER: | | ROP: | | REQ: | | GPO: | | GOR: | | SCO: | | SMA: | | SGR: | | SCB: | | SSX: | | SVL: | | SCT: | | SCY: | | SFA: | | SBH: | | SHY: | | SHO: | | SVE: | | SDV: | | SALB: | | STRP: | | KSK: | | KSE: | | ICA: | | MPH: | | NCA: | | KFL: | | NDA: | | NAL: | | TCU: | | SRO: | | FRE: | | FSY: | | NML: | | GOB: | | BSD: | | MMAR: | | SEN: | | SVI: | | TBI: | | AMD: | | AMN: | | AMM: | | PDX: | | AMI: | | SESP: | | STP: | | SAQ: | | MAU: | | MIL: | | VMA: | | AMS: | | ASE: | | CAI: | | SNA: | | CWO: | | AFO: | | AYM: | | ABA: | | ACA: | | GMA: | | SUS: | | CTM: | | CPI: | | NKO: | | PHE: | | SCN: | | HHY: | | SGN: | | BBD: | | EVI: | | DFE: | | SLI: | | LBY: | | RSI: | | FLI: | | EOL: | | FAE: | | MTT: | | GFO: | | FJO: | | FPS: | | FBR: | | FCO: | | FIN: | | RBI: | | ZPR: | | CAT: | | RAN: | | RAI: | | RAR: | | RAG: | | RAE: | | FBC: | | CAO: | | CLY: | | WVI: | | KDI: | | LAN: | | ZGA: | | MRS: | | ASL: | | PTQ: | | NDO: | | POM: | | FBA: | | FTE: | | OHO: | | GAU: | | SACI: | | CYJ: | | CEP: | | CTHE: | | PLP: | | SCS: | | IAL: | | CAU: | | CAG: | | CHL: | | HAU: | | NDE: | | MOX: | | PTO: | | SSO: | | SOL: | | SIS: | | SIA: | | SIM: | | SID: | | SIY: | | SIN: | | SII: | | SIH: | | SIR: | | SIC: | |
» show all
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| Reference |
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| Authors |
Adachi K, Iwayama Y, Tanioka H, Takeda Y. |
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| Title |
Purification and properties of homogentisate oxygenase from Pseudomonas fluorescens. |
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| Journal |
Biochim. Biophys. Acta. 118 (1966) 88-97. |
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| Organism |
Pseudomonas fluorescens |
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| Reference |
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| Authors |
CRANDALL DI, HALIKIS DN. |
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| Title |
Homogentisic acid oxidase. I. Distribution in animal tissue and relation to tyrosine metabolism in rat kidney. |
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| Journal |
J. Biol. Chem. 208 (1954) 629-38. |
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| Organism |
Rattus norvegicus [GN: rno], Bos taurus [GN: bta], Sus scofa [GN: ssc], Cavia porcellus, Oryctolagus cuniculus |
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| Reference |
3 |
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| Authors |
Hayaishi, O. |
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| Title |
Direct oxygenation by O2, oxygenases. |
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| Journal |
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 8, Academic Press, New York, 1963, p. 353-371. |
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| Reference |
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| Authors |
KITA H, KAMIMOTO M, SENOH S, ADACHI T, TAKEDA Y. |
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| Title |
CRYSTALLIZATION AND SOME PROPERTIES OF 3,4-DIHYDROXYPHENYLACETATE-2,3-OXYGENASE. |
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| Journal |
Biochem. Biophys. Res. Commun. 18 (1965) 66-70. |
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| Organism |
Pseudomonas ovalis |
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| Reference |
|
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| Authors |
KNOX WE, EDWARDS SW. |
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| Title |
Homogentisate oxidase of liver. |
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| Journal |
J. Biol. Chem. 216 (1955) 479-87. |
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| Organism |
Rattus norvegicus [GN: rno] |
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| Reference |
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| Authors |
RAVDIN RG, CRANDALL DI. |
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| Title |
The enzymatic conversion of homogentisic acid to 4-fumarylacetoacetic acid. |
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| Journal |
J. Biol. Chem. 189 (1951) 137-49. |
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| Organism |
Homo sapiens [GN: hsa], Pseudomonas fluorescens |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: UM-BBD (Biocatalysis/Biodegradation Database): BRENDA, the Enzyme Database: CAS: 9029-49-6 |
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