| Entry |
|
|---|
| Name |
protocatechuate 4,5-dioxygenase;
protocatechuate 4,5-oxygenase;
protocatechuic 4,5-dioxygenase;
protocatechuic 4,5-oxygenase |
|---|
| Class |
Oxidoreductases;
Acting on single donors with O2 as oxidant and incorporation of
oxygen into the substrate (oxygenases). The oxygen incorporated need
not be derived from O2;
With incorporation of two atoms of oxygen
 |
|---|
| Sysname |
protocatechuate:oxygen 4,5-oxidoreductase (decyclizing) |
|---|
| Reaction(IUBMB) |
protocatechuate + O2 = 4-carboxy-2-hydroxymuconate semialdehyde
[RN:R01632] |
|---|
| Reaction(KEGG) |
R01632;
(other) R03550 R04280
 |
|---|
| Substrate |
protocatechuate [CPD:C00230];
O2 [CPD:C00007] |
|---|
| Product |
4-carboxy-2-hydroxymuconate semialdehyde [CPD:C04484] |
|---|
| Cofactor |
Iron [CPD:C00023] |
|---|
| Comment |
Requires Fe2+. |
|---|
| Pathway |
PATH: ec00362 Benzoate degradation via hydroxylation
PATH: ec00623 2,4-Dichlorobenzoate degradation |
|---|
| Orthology |
KO: K04100 protocatechuate 4,5-dioxygenase, alpha chain
KO: K04101 protocatechuate 4,5-dioxygenase, beta chain |
|---|
| Genes |
KPN: KPN_04051
KPE: KPK_0043
KPU: KP1_5420
SPE: Spro_2096
XCC: XCC0804(pcaH) XCC0805(ligA)
XCB: XC_3426 XC_3427
XCA: xccb100_3546(ligA) xccb100_3547(ligB)
XCV: XCV0913(ligB) XCV0914(ligA)
XAC: XAC0878(pcaH) XAC0879(ligA)
XOO: XOO3734(pcaH)
XOM: XOO_3524 XOO_3525
XOP: PXO_04631
PPU: PP_2518
PPF: Pput_3200
PPW: PputW619_2030
AVN: Avin_31250 Avin_42210
PAT: Patl_3885 Patl_3886
TTU: TERTU_1262
CSA: Csal_0323 Csal_0324 Csal_0325
MMW: Mmwyl1_0508 Mmwyl1_0509 Mmwyl1_3920 Mmwyl1_3921 Mmwyl1_3938
Mmwyl1_3939
REU: Reut_B5775
RME: Rmet_3709
BUR: Bcep18194_C7572
BMU: Bmul_6041
BMJ: BMULJ_05486(ligB)
BPH: Bphy_3204 Bphy_3205 Bphy_6377
RFR: Rfer_0294 Rfer_0295 Rfer_0330 Rfer_0331
PNA: Pnap_2027 Pnap_2028 Pnap_2733 Pnap_2734
VEI: Veis_0170(pcmA) Veis_1369
DAC: Daci_0914 Daci_0915 Daci_3813 Daci_3814 Daci_4445 Daci_4446
CTT: CtCNB1_2741
LCH: Lcho_3636 Lcho_3637 Lcho_3698 Lcho_3699
AZO: azo2522(ligB1) azo2523(ligA1) azo2537(ligB2) azo2538(ligA2)
DAR: Daro_3248
ARA: Arad_12298
BRA: BRADO1853(ligB) BRADO2341(ligA) BRADO2342(ligB) BRADO2379
BRADO2380(mhpB)
BBT: BBta_2174(ligB) BBta_2701(ligA) BBta_2702(ligB) BBta_2733
BBta_2734(mhpB)
RPA: RPA1006 RPA1007(mhpB) RPA4701(ligA) RPA4702(ligB)
RPB: RPB_0872 RPB_0873 RPB_1060 RPB_1061
RPD: RPD_0982 RPD_0983
RPE: RPE_0750 RPE_0751
RPT: Rpal_1198 Rpal_1199 Rpal_5182 Rpal_5183
HBA: Hbal_2592 Hbal_2593 Hbal_2608
NAR: Saro_1233 Saro_1234 Saro_2812 Saro_2813
SWI: Swit_3064
MAG: amb0257 amb0258
ART: Arth_4373(pcmA)
SRO: Sros_4715
NML: Namu_0046 Namu_4104
SVI: Svir_38360
AFO: Afer_2021
PAS: Pars_0521
 |
|---|
| Structures |
PDB: 1B4U 1BOU |
|---|
Reference
Authors
Title
Journal
|
1
Trippett, S., Dagley, S. and Stopher, D.A.
The bacterial oxidation of nicotinic acid.
Biochem. J. 76 (1960) 9. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.13.11.8
IUBMB Enzyme Nomenclature: 1.13.11.8
ExPASy - ENZYME nomenclature database: 1.13.11.8
UM-BBD (Biocatalysis/Biodegradation Database): 1.13.11.8
BRENDA, the Enzyme Database: 1.13.11.8
CAS: 9029-56-5 |
|---|
