KEGG   ENZYME: 1.13.11.9Help
Entry
EC 1.13.11.9                Enzyme                                 

Name
2,5-dihydroxypyridine 5,6-dioxygenase;
2,5-dihydroxypyridine oxygenase;
pyridine-2,5-diol dioxygenase;
NicX
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
2,5-dihydroxypyridine:oxygen 5,6-oxidoreductase
Reaction(IUBMB)
2,5-dihydroxypyridine + O2 = N-formylmaleamic acid [RN:R09125]
Reaction(KEGG)
Substrate
2,5-dihydroxypyridine [CPD:C01059];
O2 [CPD:C00007]
Product
N-formylmaleamic acid [CPD:C18232]
Comment
Requires Fe2+.
History
EC 1.13.11.9 created 1965 as EC 1.13.1.9, transferred 1972 to EC 1.13.11.9, modified 2010
Pathway
Nicotinate and nicotinamide metabolism
Microbial metabolism in diverse environments
Orthology
K18028  
2,5-dihydroxypyridine 5,6-dioxygenase
Genes
SPE: 
SRR: 
SRL: 
SRY: 
SRS: 
SRA: 
SMW: 
SLQ: 
SERF: 
PAO: 
PPU: 
PPF: 
PPG: 
PPW: 
PPT: 
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PPX: 
PPUT: 
PPUN: 
PFS: 
PSK: 
ADI: 
RPJ: 
REU: 
REH: 
H16_A0925(h16_A0925) H16_B0813
CNC: 
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BMU: 
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BXE: 
BXB: 
BGD: 
BYI: 
BUO: 
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BPC: 
BPER: 
BPA: 
BPAR: 
BBR: 
BBM: 
BBH: 
BAV: 
AXY: 
AXO: 
AXN: 
AKA: 
AMIM: 
AAV: 
AAA: 
ACK: 
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DEL: 
VAP: 
CTES: 
HSE: 
RLG: 
RTR: 
BJU: 
BRS: 
AOL: 
HMC: 
PHL: 
OAR: 
GXL: 
APT: 
APW: 
APF: 
APU: 
APG: 
APQ: 
APX: 
APZ: 
APK: 
ALI: 
ABS: 
ABQ: 
MSA: 
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FAL: 
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 » show all
Taxonomy
Reference
1  [PMID:13475371]
  Authors
BEHRMAN EJ, STANIER RY.
  Title
The bacterial oxidation of nicotinic acid.
  Journal
J. Biol. Chem. 228 (1957) 923-45.
Reference
2  [PMID:5578917]
  Authors
Gauthier JJ, Rittenberg SC.
  Title
The metabolism of nicotinic acid. I. Purification and properties of 2,5-dihydroxypyridine oxygenase from Pseudomonas putida N-9.
  Journal
J. Biol. Chem. 246 (1971) 3737-42.
  Sequence
[ppu:PP_3945]
Reference
3  [PMID:5578918]
  Authors
Gauthier JJ, Rittenberg SC.
  Title
The metabolism of nicotinic acid. II. 2,5-dihydroxypyridine oxidation, product formation, and oxygen 18 incorporation.
  Journal
J. Biol. Chem. 246 (1971) 3743-8.
  Sequence
[ppu:PP_3945]
Reference
4  [PMID:18678916]
  Authors
Jimenez JI, Canales A, Jimenez-Barbero J, Ginalski K, Rychlewski L, Garcia JL, Diaz E
  Title
Deciphering the genetic determinants for aerobic nicotinic acid degradation: the  nic cluster from Pseudomonas putida KT2440.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 11329-34.
  Sequence
[ppu:PP_3945]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
9029-57-6

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