| Entry |
|
|---|
| Name |
lysine 2-monooxygenase;
lysine oxygenase;
lysine monooxygenase;
L-lysine-2-monooxygenase |
|---|
| Class |
Oxidoreductases;
Acting on single donors with O2 as oxidant and incorporation of
oxygen into the substrate (oxygenases). The oxygen incorporated need
not be derived from O2;
With incorporation of one atom of oxygen (internal monooxygenases or
internal mixed-function oxidases)
 |
|---|
| Sysname |
L-lysine:oxygen 2-oxidoreductase (decarboxylating) |
|---|
| Reaction(IUBMB) |
L-lysine + O2 = 5-aminopentanamide + CO2 + H2O [RN:R00449] |
|---|
| Reaction(KEGG) |
R00449
 |
|---|
| Substrate |
L-lysine [CPD:C00047];
O2 [CPD:C00007] |
|---|
| Product |
5-aminopentanamide [CPD:C00990];
CO2 [CPD:C00011];
H2O [CPD:C00001] |
|---|
| Cofactor |
FAD [CPD:C00016] |
|---|
| Comment |
A flavoprotein (FAD). Also acts on other diamino acids. |
|---|
| Pathway |
PATH: ec00310 Lysine degradation |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:4624115]
Nakazawa T, Hori K, Hayaishi O.
Studies on monooxygenases. V. Manifestation of amino acid oxidase
activity by L-lysine monooxygenase.
J. Biol. Chem. 247 (1972) 3439-44.
Pseudomonas fluorescens |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:5911646]
Takeda H, Hayaishi O.
Crystalline L-lysine oxygenase.
J. Biol. Chem. 241 (1966) 2733-6.
Pseudomonas fluorescens |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:5772467]
Takeda H, Yamamoto S, Kojima Y, Hayaishi O.
Studies on monooxygenases. I. General properties of crystalline
L-lysine monooxygenase.
J. Biol. Chem. 244 (1969) 2935-41.
Pseudomonas fluorescens |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.13.12.2
IUBMB Enzyme Nomenclature: 1.13.12.2
ExPASy - ENZYME nomenclature database: 1.13.12.2
BRENDA, the Enzyme Database: 1.13.12.2
CAS: 9031-22-5 |
|---|
