| Entry |
|
|---|
| Name |
lactate 2-monooxygenase;
lactate oxidative decarboxylase;
lactate oxidase;
lactic oxygenase;
lactate oxygenase;
lactic oxidase;
L-lactate monooxygenase;
lactate monooxygenase;
L-lactate-2-monooxygenase |
|---|
| Class |
Oxidoreductases;
Acting on single donors with O2 as oxidant and incorporation of
oxygen into the substrate (oxygenases). The oxygen incorporated need
not be derived from O2;
With incorporation of one atom of oxygen (internal monooxygenases or
internal mixed-function oxidases)
 |
|---|
| Sysname |
(S)-lactate:oxygen 2-oxidoreductase (decarboxylating) |
|---|
| Reaction(IUBMB) |
(S)-lactate + O2 = acetate + CO2 + H2O [RN:R00319] |
|---|
| Reaction(KEGG) |
R00319
 |
|---|
| Substrate |
(S)-lactate [CPD:C00186];
O2 [CPD:C00007] |
|---|
| Product |
acetate [CPD:C00033];
CO2 [CPD:C00011];
H2O [CPD:C00001] |
|---|
| Cofactor |
FMN [CPD:C00061] |
|---|
| Comment |
A flavoprotein (FMN). |
|---|
| Pathway |
PATH: ec00620 Pyruvate metabolism |
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| Orthology |
KO: K00467 lactate 2-monooxygenase |
|---|
| Genes |
MGR: MGG_05735
AFM: AFUA_4G07050
CCR: CC_1396
LSA: LSA0664(loxL1N) LSA0665(loxL1I) LSA0666(loxL1C)
MAV: MAV_3747 MAV_4345
MSM: MSMEG_2512 MSMEG_3962
MMC: Mmcs_1989
MJL: Mjls_1969
SEN: SACE_6523
RXY: Rxyl_1052
DGE: Dgeo_0626
TTH: TTC1744
PTO: PTO1012
 |
|---|
| Structures |
PDB: 2DU2 2E77 2NLI 2ZFA |
|---|
Reference
Authors
Title
Journal
|
1
Hayaishi, O. and Sutton, W.B.
Enzymatic oxygen fixation into acetate concomitant with the
enzymatic decarboxylation of L-lactate.
J. Am. Chem. Soc. 79 (1957) 4809-4810. |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:13428772]
SUTTON WB.
Mechanism of action and crystallization of lactic oxidative
decarboxylase from Mycobacterium phlei.
J. Biol. Chem. 226 (1957) 395-405.
Mycobacterium phlei |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.13.12.4
IUBMB Enzyme Nomenclature: 1.13.12.4
ExPASy - ENZYME nomenclature database: 1.13.12.4
BRENDA, the Enzyme Database: 1.13.12.4
CAS: 9028-72-2 |
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