KEGG   ENZYME: 1.14.11.1Help
Entry
EC 1.14.11.1                Enzyme                                 
Name gamma-butyrobetaine dioxygenase;
alpha-butyrobetaine hydroxylase;
gamma-butyrobetaine hydroxylase;
butyrobetaine hydroxylase
Class Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or
reduction of oxygen. The oxygen incorporated need not be derived
from O2;
With 2-oxoglutarate as one donor, and incorporation of one atom of
oxygen into each donor
BRITE hierarchy
Sysname 4-trimethylammoniobutanoate,2-oxoglutarate:oxygen oxidoreductase
(3-hydroxylating)
Reaction(IUBMB) 4-trimethylammoniobutanoate + 2-oxoglutarate + O2 =
3-hydroxy-4-trimethylammoniobutanoate + succinate + CO2 [RN:R02397]
Reaction(KEGG) R02397
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Substrate 4-trimethylammoniobutanoate [CPD:C01181];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product 3-hydroxy-4-trimethylammoniobutanoate [CPD:C00487];
succinate [CPD:C00042];
CO2 [CPD:C00011]
Cofactor Iron [CPD:C00023];
Ascorbate [CPD:C00072]
Comment Requires Fe2+ and ascorbate.
Pathway PATH: ec00310  Lysine degradation
Orthology KO: K00471  gamma-butyrobetaine dioxygenase
Genes HSA: 8424(BBOX1)
PTR: 466474(BBOX1)
MCC: 699465(BBOX1)
MMU: 170442(Bbox1)
RNO: 64564(Bbox1)
CFA: 476894(BBOX1)
BTA: 507159(BBOX1)
ECB: 100072253
MDO: 100030745
GGA: 426932(BBOX1)
TGU: 100222550
DRE: 572649(bbox1)
DME: Dmel_CG10814 Dmel_CG4335 Dmel_CG5321
DPO: Dpse_GA18803
CEL: D2089.5(gbh-1) M05D6.7(gbh-2)
NVE: NEMVE_v1g167335
PIC: PICST_33061(GBO1)
PFL: PFL_5756
PFO: Pfl01_5234
PMY: Pmen_0503
CSA: Csal_0540 Csal_2770
BPS: BPSS1110
BPM: BURPS1710b_A0070 BURPS1710b_A1680(pvcB)
BPL: BURPS1106A_A1481
BPD: BURPS668_A1569
BVI: Bcep1808_3389
BUR: Bcep18194_B0616
BCN: Bcen_3320
BCH: Bcen2424_5047
BAM: Bamb_4455
MLO: mll1440
SIL: SPO3380
SIT: TM1040_0052 TM1040_0333 TM1040_2006
TER: Tery_0693
Taxonomy
Reference
  Authors
  Title

  Journal
  Organism
 1  [PMID:4396068]
Lindstedt G, Lindstedt S.
Cofactor requirements of gamma-butyrobetaine hydroxylase from rat
liver.
J. Biol. Chem. 245 (1970) 4178-86.
Rattus norvegicus [GN:rno]
Other DBs ExplorEnz - The Enzyme Database: 1.14.11.1
IUBMB Enzyme Nomenclature: 1.14.11.1
ExPASy - ENZYME nomenclature database: 1.14.11.1
BRENDA, the Enzyme Database: 1.14.11.1
CAS: 9045-31-2
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