| Entry |
|
|---|
| Name |
procollagen-proline dioxygenase;
protocollagen hydroxylase;
proline hydroxylase;
proline,2-oxoglutarate 4-dioxygenase;
collagen proline hydroxylase;
hydroxylase, collagen proline;
peptidyl proline hydroxylase;
proline protocollagen hydroxylase;
proline, 2-oxoglutarate dioxygenase;
prolyl hydroxylase;
prolylprotocollagen dioxygenase;
prolylprotocollagen hydroxylase;
protocollagen proline 4-hydroxylase;
protocollagen proline dioxygenase;
protocollagen proline hydroxylase;
protocollagen prolyl hydroxylase;
prolyl 4-hydroxylase;
prolyl-glycyl-peptide, 2-oxoglutarate:oxygen oxidoreductase,
4-hydroxylating;
procollagen-proline 4-dioxygenase |
|---|
| Class |
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or
reduction of oxygen. The oxygen incorporated need not be derived
from O2;
With 2-oxoglutarate as one donor, and incorporation of one atom of
oxygen into each donor
 |
|---|
| Sysname |
procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase
(4-hydroxylating) |
|---|
| Reaction(IUBMB) |
procollagen L-proline + 2-oxoglutarate + O2 = procollagen
trans-4-hydroxy-L-proline + succinate + CO2 [RN:R03219] |
|---|
| Reaction(KEGG) |
R03219;
(other) R01252
 |
|---|
| Substrate |
procollagen L-proline [CPD:C01078];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007] |
|---|
| Product |
procollagen trans-4-hydroxy-L-proline [CPD:C04398];
succinate [CPD:C00042];
CO2 [CPD:C00011] |
|---|
| Cofactor |
Iron [CPD:C00023];
Ascorbate [CPD:C00072] |
|---|
| Comment |
Requires Fe2+ and ascorbate. |
|---|
| Pathway |
PATH: ec00330 Arginine and proline metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00472 prolyl 4-hydroxylase |
|---|
| Genes |
HSA: 283208(P4HA3) 5033(P4HA1) 8974(P4HA2)
PTR: 450891(P4HA1) 462047(P4HA2) 748564(P4HA3)
MCC: 707157(P4HA2) 707927(P4HA1) 718872
MMU: 18451(P4ha1) 18452(P4ha2) 320452(P4ha3)
RNO: 360526(P4ha2) 361612(P4ha3) 64475(P4ha1)
CFA: 474672(P4HA2) 479242(P4HA1) 609381(P4HA3)
BTA: 414348(P4HA3) 507327(P4HA2) 518288(P4HA1)
SSC: 100037299(P4HA1)
ECB: 100063760 100065260 100072882
MDO: 100013447 100018258
OAA: 100079170
GGA: 416326(P4HA2) 423704(P4HA1)
TGU: 100226743 100228350
XLA: 447527
XTR: 493342(p4ha2)
DRE: 100003675(p4ha1) 373132(p4ha2) 556879 563281(zgc:103728)
SPU: 592929
DME: Dmel_CG11828 Dmel_CG1546(PH4alphaSG2) Dmel_CG15539 Dmel_CG18749
Dmel_CG31014(PH4alphaSG1) Dmel_CG31015(PH4alphaPV) Dmel_CG31016
Dmel_CG31017(PH4alphaNE3) Dmel_CG31022(PH4alphaEFB)
Dmel_CG31524 Dmel_CG32199 Dmel_CG32201 Dmel_CG34345 Dmel_CG4174
Dmel_CG9698 Dmel_CG9720(PH4alphaNE2) Dmel_CG9726(PH4alphaMP)
Dmel_CG9728(PH4alphaNE1)
DPO: Dpse_GA13747 Dpse_GA15939 Dpse_GA15946
AAG: AaeL_AAEL007038
AME: 408862
CEL: F35G2.4(phy-2) Y47D3B.10(dpy-18)
NVE: NEMVE_v1g120212 NEMVE_v1g120225 NEMVE_v1g195205
ATH: AT3G28480
OLU: OSTLU_37102
MGR: MGG_06278
ANI: AN2851.2
AOR: AO090003000761
ANG: An02g07870
DDI: DDB_0238387
TAN: TA04445
PRW: PsycPRwf_1859
AFE: Lferr_2737
AFR: AFE_1210
RPI: Rpic_3059
RPF: Rpic12D_2649
REU: Reut_A2950
REH: H16_A3244(phy)
RME: Rmet_3098
CTI: RALTA_A2697
BXE: Bxe_B1199
BPY: Bphyt_5409
POL: Bpro_3712
AAV: Aave_1171
AJS: Ajs_3293
DIA: Dtpsy_2646
BBT: BBta_1313
BAN: BA4459
BAR: GBAA4459
BAA: BA_4910
BAT: BAS4138
BCE: BC4233
BCA: BCE_4314
BCZ: BCZK3988
BTK: BT9727_3978
BTL: BALH_3835
 |
|---|
| Structures |
PDB: 1TJC 2V5F |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:4346946]
Berg RA, Prockop DJ.
Affinity column purification of protocollagen proline hydroxylase
from chick embryos and further characterization of the enzyme.
J. Biol. Chem. 248 (1973) 1175-82.
Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
|
2
Hutton, J.J., Jr., Tappel, A.L. and Udenfriend, S.
Cofactor and substrate requirements of collagen proline hydroxylase.
Arch. Biochem. Biophys. 118 (1967) 231-240. |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:5046811]
Kivirikko KI, Kishida Y, Sakakibara S, Prockop DJ.
Hydroxylation of (X-Pro-Gly)n by protocollagen proline hydroxylase.
Effect of chain length, helical conformation and amino acid sequence
in the substrate.
Biochim. Biophys. Acta. 271 (1972) 347-56.
Rattus norvegicus [GN:rno], Gallus gallus [GN:gga] |
|---|
Reference
Authors
Title
Journal
|
4
Kivirikko, K.I. and Prockop, D.J.
Purification and partial characterization of the enzyme for the
hydroxylation of proline in protocollogen.
Arch. Biochem. Biophys. 118 (1967) 611-618. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.14.11.2
IUBMB Enzyme Nomenclature: 1.14.11.2
ExPASy - ENZYME nomenclature database: 1.14.11.2
BRENDA, the Enzyme Database: 1.14.11.2
CAS: 9028-06-2 |
|---|
