KEGG   ENZYME: 1.14.11.2Help
Entry
EC 1.14.11.2                Enzyme                                 

Name
procollagen-proline dioxygenase;
protocollagen hydroxylase;
proline hydroxylase;
proline,2-oxoglutarate 4-dioxygenase;
collagen proline hydroxylase;
hydroxylase, collagen proline;
peptidyl proline hydroxylase;
proline protocollagen hydroxylase;
proline, 2-oxoglutarate dioxygenase;
prolyl hydroxylase;
prolylprotocollagen dioxygenase;
prolylprotocollagen hydroxylase;
protocollagen proline 4-hydroxylase;
protocollagen proline dioxygenase;
protocollagen proline hydroxylase;
protocollagen prolyl hydroxylase;
prolyl 4-hydroxylase;
prolyl-glycyl-peptide, 2-oxoglutarate:oxygen oxidoreductase, 4-hydroxylating;
procollagen-proline 4-dioxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
BRITE hierarchy
Sysname
procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating)
Reaction(IUBMB)
procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2 [RN:R03219]
Reaction(KEGG)
R03219;
(other) R01252
Show
Substrate
procollagen L-proline [CPD:C01078];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product
procollagen trans-4-hydroxy-L-proline [CPD:C04398];
succinate [CPD:C00042];
CO2 [CPD:C00011]
Comment
Requires Fe2+ and ascorbate.
History
EC 1.14.11.2 created 1972, modified 1981, modified 1983
Pathway
Arginine and proline metabolism
Metabolic pathways
Orthology
K00472  
prolyl 4-hydroxylase
Genes
HSA: 
283208(P4HA3) 5033(P4HA1) 8974(P4HA2)
PTR: 
450891(P4HA1) 462047(P4HA2) 748564(P4HA3)
PPS: 
100976439(P4HA3) 100992298(P4HA1) 100993331(P4HA2)
GGO: 
101131612(P4HA1) 101133984(P4HA2) 101143792(P4HA3)
PON: 
100172658(P4HA1) 100433561(P4HA3) 100448172(P4HA2)
MCC: 
707157(P4HA2) 707927(P4HA1) 718872
MCF: 
MMU: 
18451(P4ha1) 18452(P4ha2) 320452(P4ha3)
RNO: 
360526(P4ha2) 361612(P4ha3) 64475(P4ha1)
CGE: 
100757890(P4ha1) 100760683(P4ha2) 100766769(P4ha3)
HGL: 
101702867(P4ha1) 101711128(P4ha3) 101724121(P4ha2)
TUP: 
102482017(P4HA3) 102488136(P4HA1) 102497816(P4HA2)
CFA: 
474672(P4HA2) 479242(P4HA1) 609381(P4HA3)
AML: 
FCA: 
101081160(P4HA3) 101094394(P4HA2) 101096846(P4HA1)
PTG: 
102954449(P4HA3) 102964926(P4HA2) 102968339(P4HA1)
BTA: 
414348(P4HA3) 507327(P4HA2) 518288(P4HA1)
BOM: 
102274070(P4HA1) 102274248(P4HA2) 102280992(P4HA3)
PHD: 
102333228(P4HA1) 102335098(P4HA3) 102339818(P4HA2)
CHX: 
102179448(P4HA1) 102186234(P4HA3) 102189116(P4HA2)
OAS: 
SSC: 
100037299(P4HA1) 100623801(P4HA2) 100624543(P4HA3)
CFR: 
102510786(P4HA1) 102516186(P4HA3) 102522559(P4HA2)
BACU: 
102997313 103004544(P4HA1) 103005873(P4HA2) 103012665(P4HA3)
LVE: 
103069084(P4HA1) 103072346(P4HA3) 103089373(P4HA2)
ECB: 
MYB: 
102239530 102242052(P4HA2) 102245712(P4HA3) 102255473(P4HA1)
MYD: 
102767574(P4HA2) 102771133(P4HA3) 102775235(P4HA1)
PALE: 
102882040(P4HA3) 102885589(P4HA1) 102892298(P4HA2)
MDO: 
100010507(P4HA1) 100013447(P4HA3) 100018258(P4HA2)
SHR: 
OAA: 
100077226(P4HA1) 100079170(P4HA2)
GGA: 
416326(P4HA2) 419057(P4HA3) 423704(P4HA1)
MGP: 
TGU: 
100222421 100223373(P4HA3) 100226743(P4HA2) 100228350(P4HA1)
FAB: 
PHI: 
102110972(P4HA3) 102113563(P4HA2) 102114022(P4HA1)
APLA: 
101792390(P4HA2) 101799325(P4HA3) 101802328(P4HA1)
FPG: 
101913115(P4HA2) 101915502(P4HA1) 101921488(P4HA3)
FCH: 
102047744(P4HA2) 102052133(P4HA1) 102054422(P4HA3)
CLV: 
102092707(P4HA3) 102096249(P4HA1) 102096911(P4HA2)
ASN: 
102370647(P4HA3) 102373565(P4HA2) 102376142(P4HA1)
AMJ: 
102557660(P4HA1) 102562067(P4HA2) 102569283(P4HA3)
PSS: 
102449785(P4HA1) 102451448(P4HA2) 102458696(P4HA3)
CMY: 
102932371(P4HA1) 102933622(P4HA2) 102935870(P4HA3)
ACS: 
PBI: 
XLA: 
447527(p4ha2)
XTR: 
DRE: 
100003675(p4ha1b) 373132(p4ha2) 556879 562774(p4ha1a) 563281(p4ha3)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102346232(P4HA2) 102360424(P4HA3) 102363342(P4HA1)
CMK: 
103177143(p4ha3) 103181221(p4ha1) 103184118(p4ha2)
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
408862(PH4alphaEFB)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG06252(Cbr-phy-2) CBG13195(Cbr-dpy-18)
BMY: 
LOA: 
TSP: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
ATH: 
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
MTR: 
CAM: 
FVE: 
PPER: 
CSV: 
RCU: 
POP: 
POPTR_0001s30400g(POPTRDRAFT_707400) POPTR_0002s01820g POPTR_0002s23310g(POPTRDRAFT_830522) POPTR_0005s10980g POPTR_0005s26660g(POPTRDRAFT_801579) POPTR_0007s09270g POPTR_0007s10120g POPTR_0008s20230g(POPTRDRAFT_1085714) POPTR_0009s09420g(POPTRDRAFT_1087308) POPTR_0010s02790g(POPTRDRAFT_657945) POPTR_0012s13040g(POPTRDRAFT_570439) POPTR_0017s11150g(POPTRDRAFT_1105096) POPTR_0017s11170g(POPTRDRAFT_908378)
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os01t0174500-01(Os01g0174500) Os03t0166100-00(Os03g0166100) Os03t0166200-00(Os03g0166200) Os03t0761900-01(Os03g0761900) Os03t0803500-01(Os03g0803500) Os04t0346000-01(Os04g0346000) Os05t0489100-01(Os05g0489100) Os07t0194500-01(Os07g0194500) Os10t0413500-01(Os10g0413500) Os10t0497800-01(Os10g0497800)
OBR: 
BDI: 
SBI: 
SORBI_01g004670(SORBIDRAFT_01g004670) SORBI_01g007280(SORBIDRAFT_01g007280) SORBI_01g018200(SORBIDRAFT_01g018200) SORBI_01g022150(SORBIDRAFT_01g022150) SORBI_02g005750(SORBIDRAFT_02g005750) SORBI_02g005760(SORBIDRAFT_02g005760) SORBI_03g004265(SORBIDRAFT_03g004265) SORBI_04g038020(SORBIDRAFT_04g038020) SORBI_06g004550(SORBIDRAFT_06g004550) SORBI_08g016950(SORBIDRAFT_08g016950) SORBI_09g023860(SORBIDRAFT_09g023860)
ZMA: 
100193348 100193935(pco071536) 100274058 100282945(pco107217) 100283657(cl32377_1(260)) 100284871(pco093706) 100303994 100383727 100857079(P4H2-1) 100857080(P4H4) 100857081(P4H4-2) 100857082(P4H5-1) 100857083(P4H6) 100857087(P4H6-3) 100857088(P4H8-2) 100857089(P4H8-3) 100857090(P4H8-4) 100857091(P4H8-5)
SITA: 
ATR: 
s00001p00155640(AMTR_s00001p00155640) s00005p00135530(AMTR_s00005p00135530) s00019p00257460(AMTR_s00019p00257460) s00081p00029310(AMTR_s00081p00029310) s00098p00019020(AMTR_s00098p00019020) s00098p00020560(AMTR_s00098p00020560) s00144p00069890(AMTR_s00144p00069890)
SMO: 
PPP: 
CRE: 
VCN: 
OLU: 
OTA: 
BPG: 
MIS: 
MPP: 
CSL: 
CVR: 
NCR: 
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
FGR: 
NHE: 
TRE: 
MAJ: 
CMT: 
VAL: 
ELA: 
SSL: 
BFU: 
MBE: 
ANI: 
AFM: 
AOR: 
AOR_1_1350154(AO090003000761)
ANG: 
ANI_1_2732024(An02g07870)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
BCOM: 
NPA: 
MBR: 
DDI: 
DPP: 
DFA: 
TAN: 
BEQ: 
TGO: 
PTI: 
TPS: 
PIF: 
NGD: 
EHX: 
GTT: 
XCC: 
XCB: 
XCP: 
XCV: 
XAC: 
XCI: 
XAX: 
XAO: 
XFU: 
PSU: 
PSD: 
RHD: 
DJI: 
PRW: 
SDE: 
AMC: 
AMAC: 
AMB: 
AMG: 
AMH: 
AMK: 
AMAA: 
AMAL: 
AMAE: 
AMAO: 
AMAD: 
AMAI: 
AMAG: 
ALT: 
MMT: 
TKM: 
AFE: 
AFR: 
AFI: 
SAGA: 
RSO: 
RSC: 
RSL: 
RSN: 
RSM: 
RSE: 
RPI: 
RPF: 
RPJ: 
REU: 
REH: 
CNC: 
RME: 
CTI: 
BXE: 
BPH: 
BPY: 
BUG: 
BGE: 
BGF: 
BGD: 
BYI: 
BPX: 
POL: 
AAV: 
AJS: 
DIA: 
AAA: 
ACK: 
DAC: 
DEL: 
VAP: 
VPE: 
VPD: 
CTT: 
ADN: 
ADK: 
RTA: 
MPT: 
CFU: 
LCH: 
RGE: 
BBT: 
HNE: 
NAR: 
NPP: 
SAL: 
SWI: 
SJP: 
SCH: 
SSY: 
ELI: 
BAN: 
BAR: 
BAT: 
BAH: 
BAI: 
BAX: 
BANT: 
BANR: 
BANS: 
BAL: 
BCE: 
BCA: 
BCZ: 
BCR: 
BCB: 
BCU: 
BCG: 
BCQ: 
BCX: 
BNC: 
BCF: 
BCER: 
BTK: 
BTL: 
BTB: 
BTT: 
BTC: 
BTF: 
BTM: 
BTG: 
BTI: 
BTN: 
BTHT: 
BTHU: 
BWE: 
BTY: 
BMQ: 
BMD: 
BMH: 
BCO: 
BIF: 
HHD: 
BBE: 
PJD: 
TCO: 
SIV: 
AYM: 
SYW: 
SYD: 
SYE: 
HAO: 
 » show all
Taxonomy
Reference
1  [PMID:4346946]
  Authors
Berg RA, Prockop DJ.
  Title
Affinity column purification of protocollagen proline hydroxylase from chick embryos and further characterization of the enzyme.
  Journal
J. Biol. Chem. 248 (1973) 1175-82.
  Organism
Rattus norvegicus
Reference
2
  Authors
Hutton, J.J., Jr., Tappel, A.L. and Udenfriend, S.
  Title
Cofactor and substrate requirements of collagen proline hydroxylase.
  Journal
Arch. Biochem. Biophys. 118 (1967) 231-240.
Reference
3  [PMID:5046811]
  Authors
Kivirikko KI, Kishida Y, Sakakibara S, Prockop DJ.
  Title
Hydroxylation of (X-Pro-Gly)n by protocollagen proline hydroxylase. Effect of chain length, helical conformation and amino acid sequence in the substrate.
  Journal
Biochim. Biophys. Acta. 271 (1972) 347-56.
  Organism
Rattus norvegicus, Gallus gallus
Reference
4
  Authors
Kivirikko, K.I. and Prockop, D.J.
  Title
Purification and partial characterization of the enzyme for the hydroxylation of proline in protocollogen.
  Journal
Arch. Biochem. Biophys. 118 (1967) 611-618.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9028-06-2

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