| Entry |
|
|---|
| Name |
flavone synthase |
|---|
| Class |
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or
reduction of oxygen. The oxygen incorporated need not be derived
from O2;
With 2-oxoglutarate as one donor, and incorporation of one atom of
oxygen into each donor
 |
|---|
| Sysname |
flavanone,2-oxoglutarate:oxygen oxidoreductase (dehydrating) |
|---|
| Reaction(IUBMB) |
a flavanone + 2-oxoglutarate + O2 = a flavone + succinate + CO2 +
H2O [RN:R07367] |
|---|
| Reaction(KEGG) |
R07367 > R02445 R03590 R06551 R08081
 |
|---|
| Substrate |
flavanone [CPD:C00766];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007] |
|---|
| Product |
flavone [CPD:C10043];
succinate [CPD:C00042];
CO2 [CPD:C00011];
H2O [CPD:C00001] |
|---|
| Comment |
Requires ascorbate for full activity and Fe2+. |
|---|
| Pathway |
PATH: ec00941 Flavonoid biosynthesis
PATH: ec00943 Isoflavonoid biosynthesis
PATH: ec01061 Biosynthesis of phenylpropanoids
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K13077 flavone synthase |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:11524111]
Martens S, Forkmann G, Matern U, Lukacin R.
Cloning of parsley flavone synthase I.
Phytochemistry. 58 (2001) 43-6.
Petroselinum crispum |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:11516175]
Lukacin R, Matern U, Junghanns KT, Heskamp ML, Britsch L, Forkmann
G, Martens S.
Purification and antigenicity of flavone synthase I from irradiated
parsley cells.
Arch. Biochem. Biophys. 393 (2001) 177-83.
Apiaceae sp. |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:12782296]
Martens S, Forkmann G, Britsch L, Wellmann F, Matern U, Lukacin R.
Divergent evolution of flavonoid 2-oxoglutarate-dependent
dioxygenases in parsley.
FEBS. Lett. 544 (2003) 93-8.
Apiaceae sp. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.14.11.22
IUBMB Enzyme Nomenclature: 1.14.11.22
ExPASy - ENZYME nomenclature database: 1.14.11.22
BRENDA, the Enzyme Database: 1.14.11.22
CAS: 138263-98-6 |
|---|
