KEGG   ENZYME: 1.14.11.4Help
Entry
EC 1.14.11.4                Enzyme                                 
Name
procollagen-lysine 5-dioxygenase;
lysine hydroxylase;
lysine,2-oxoglutarate 5-dioxygenase;
protocollagen lysine dioxygenase;
collagen lysine hydroxylase;
lysine-2-oxoglutarate dioxygenase;
lysyl hydroxylase;
lysylprotocollagen dioxygenase;
protocollagen lysyl hydroxylase;
peptidyl-lysine, 2-oxoglutarate: oxygen oxidoreductase;
peptidyllysine, 2-oxoglutarate:oxygen 5-oxidoreductase;
protocollagen lysine hydroxylase;
procollagen-L-lysine,2-oxoglutarate:oxygen oxidoreductase (5-hydroxylating)
Class
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
BRITE hierarchy
Sysname
L-lysine-[procollagen],2-oxoglutarate:oxygen oxidoreductase (5-hydroxylating)
Reaction(IUBMB)
L-lysine-[procollagen] + 2-oxoglutarate + O2 = (2S,5R)- 5-hydroxy-L-lysine-[procollagen] + succinate + CO2
Reaction(KEGG)
(other) R03376
Show
Substrate
L-lysine-[procollagen];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product
(2S,5R)- 5-hydroxy-L-lysine-[procollagen];
succinate [CPD:C00042];
CO2 [CPD:C00011]
Comment
Requires Fe2+ and ascorbate.
Pathway
Lysine degradation
Orthology
K00473  
procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
K13645  
procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
K13646  
lysyl hydroxylase/galactosyltransferase/glucosyltransferase
K13647  
procollagen-lysine,2-oxoglutarate 5-dioxygenase, invertebrate
Genes
HSA: 
5351(PLOD1) 5352(PLOD2) 8985(PLOD3)
PTR: 
457956(PLOD1) 460754(PLOD2) 463618(PLOD3)
PPS: 
100968399(PLOD3) 100969240(PLOD2) 100973324(PLOD1)
GGO: 
101123821(PLOD2) 101141181(PLOD1) 101151570(PLOD3)
PON: 
100174498(PLOD1) 100189797(DKFZP469F124) 100460115(PLOD2)
MCC: 
MMU: 
18822(Plod1) 26432(Plod2) 26433(Plod3)
RNO: 
116552(Plod1) 288583(Plod3) 300901(Plod2)
CFA: 
479730(PLOD3) 485702(PLOD2) 487440(PLOD1)
AML: 
FCA: 
101085741(PLOD2) 101089668(PLOD3) 101100822(PLOD1)
BTA: 
281409(PLOD1) 514996(PLOD3) 533642(PLOD2)
SSC: 
100525583(PLOD1) 641354(PLOD2)
ECB: 
100050902 100059479(PLOD3) 100061030(PLOD2)
MDO: 
100017782(PLOD3) 100017955 100018666(PLOD2)
SHR: 
100921874(PLOD3) 100928031(PLOD2) 100928370(PLOD1)
OAA: 
100074679(PLOD2) 100076869 100086224(PLOD3)
GGA: 
419485(PLOD1) 424882(PLOD2)
MGP: 
100542606 100544189(PLOD2)
TGU: 
100217784(PLOD1) 100224084(PLOD2)
ACS: 
100558042 100558233(plod2)
XLA: 
380138(plod3) 495112(plod1)
XTR: 
100489636 734090(plod3) 779793(plod1)
DRE: 
100036767(plod2) 322766(fb72h05) 556077(plod3) 777635(plod1a)
TRU: 
100101241(fglh1) 100101242(fglh3) 100101243(fglh2)
OLA: 
101160794 101171207
CIN: 
100178986
SPU: 
576306
DME: 
Dmel_CG6199(Plod)
DPO: 
Dpse_GA19434
DAN: 
Dana_GF24561
DER: 
Dere_GG13929
DPE: 
Dper_GL22837
DSE: 
Dsec_GM24765
DSI: 
Dsim_GD12814
DWI: 
Dwil_GK20548
DYA: 
Dyak_GE20228
DGR: 
Dgri_GH16659
DMO: 
Dmoj_GI11618
DVI: 
Dvir_GJ11296
AGA: 
AgaP_AGAP001507
AAG: 
AaeL_AAEL008099
CQU: 
CpipJ_CPIJ011582
AME: 
100578909
NVI: 
100117467(NV13234)
TCA: 
662642
API: 
100162555
PHU: 
Phum_PHUM397420
ISC: 
IscW_ISCW007221
CEL: 
CELE_F52H3.1(let-268)
CBR: 
CBG13377(Cbr-let-268)
BMY: 
Bm1_42125
TSP: 
Tsp_03029
NVE: 
NEMVE_v1g234891
HMG: 
100212717
TAD: 
TRIADDRAFT_50405
AQU: 
100636459
 » show all
Taxonomy
Reference
1  [PMID:6033801]
  Authors
Hausmann E.
  Title
Cofactor requirements for the enzymatic hydroxylation of lysine in a polypeptide precursor of collagen.
  Journal
Biochim. Biophys. Acta. 133 (1967) 591-3.
  Organism
Gallus gallus [GN:gga]
Reference
2  [PMID:5244754]
  Authors
Rhoads RE, Udenfriend S.
  Title
Decarboxylation of alpha-ketoglutarate coupled to collagen proline hydroxylase.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 60 (1968) 1473-8.
  Organism
Rattus norvegicus [GN:rno]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9059-25-0
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