KEGG   ENZYME: 1.14.11.4Help
Entry
EC 1.14.11.4                Enzyme                                 

Name
procollagen-lysine 5-dioxygenase;
lysine hydroxylase;
lysine,2-oxoglutarate 5-dioxygenase;
protocollagen lysine dioxygenase;
collagen lysine hydroxylase;
lysine-2-oxoglutarate dioxygenase;
lysyl hydroxylase;
lysylprotocollagen dioxygenase;
protocollagen lysyl hydroxylase;
peptidyl-lysine, 2-oxoglutarate: oxygen oxidoreductase;
peptidyllysine, 2-oxoglutarate:oxygen 5-oxidoreductase;
protocollagen lysine hydroxylase;
procollagen-L-lysine,2-oxoglutarate:oxygen oxidoreductase (5-hydroxylating)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
BRITE hierarchy
Sysname
L-lysine-[procollagen],2-oxoglutarate:oxygen oxidoreductase (5-hydroxylating)
Reaction(IUBMB)
L-lysine-[procollagen] + 2-oxoglutarate + O2 = (2S,5R)- 5-hydroxy-L-lysine-[procollagen] + succinate + CO2
Reaction(KEGG)
(other) R03376
Show
Substrate
L-lysine-[procollagen];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product
(2S,5R)- 5-hydroxy-L-lysine-[procollagen];
succinate [CPD:C00042];
CO2 [CPD:C00011]
Comment
Requires Fe2+ and ascorbate.
History
EC 1.14.11.4 created 1972, modified 1983
Pathway
Lysine degradation
Orthology
K00473  
procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
K13645  
procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
K13646  
lysyl hydroxylase/galactosyltransferase/glucosyltransferase
K13647  
procollagen-lysine,2-oxoglutarate 5-dioxygenase, invertebrate
Genes
HSA: 
5351(PLOD1) 5352(PLOD2) 8985(PLOD3)
PTR: 
457956(PLOD1) 460754(PLOD2) 463618(PLOD3)
PPS: 
100968399(PLOD3) 100969240(PLOD2) 100973324(PLOD1)
GGO: 
101123821(PLOD2) 101141181(PLOD1) 101151570(PLOD3)
PON: 
100174498(PLOD1) 100189797(DKFZP469F124) 100460115(PLOD2)
NLE: 
100597272(PLOD3) 100598845(PLOD1) 100605215(PLOD2)
MCC: 
MCF: 
CJC: 
100390092(PLOD3) 100393790(PLOD1) 100409327(PLOD2)
MMU: 
18822(Plod1) 26432(Plod2) 26433(Plod3)
RNO: 
116552(Plod1) 288583(Plod3) 300901(Plod2)
CGE: 
100762939(Plod2) 100763844(Plod1)
HGL: 
101701075(Plod3) 101708679(Plod2) 101716463(Plod1)
TUP: 
102475334(PLOD1) 102476916(PLOD3) 102495899(PLOD2)
CFA: 
479730(PLOD3) 485702(PLOD2) 487440(PLOD1)
AML: 
UMR: 
103666856(PLOD1) 103670197(PLOD3) 103681519(PLOD2)
FCA: 
101085741(PLOD2) 101089668(PLOD3) 101100822(PLOD1)
PTG: 
102950927(PLOD3) 102968272(PLOD1) 102970252(PLOD2)
BTA: 
281409(PLOD1) 514996(PLOD3) 533642(PLOD2)
BOM: 
102276636(PLOD3) 102281451(PLOD2) 102288243(PLOD1)
PHD: 
102317489(PLOD2) 102321876(PLOD3) 102325667(PLOD1)
CHX: 
OAS: 
101103613(PLOD2) 101111306(PLOD1) 101121738(PLOD3)
SSC: 
100525583(PLOD1) 100624420(PLOD3) 641354(PLOD2)
CFR: 
102505707(PLOD3) 102508417(PLOD1) 102512817(PLOD2)
BACU: 
102997634(PLOD2) 103018042(PLOD3) 103020558(PLOD1)
LVE: 
103080972(PLOD1) 103086765 103090004(PLOD2) 103090807(PLOD3)
ECB: 
100050902(PLOD1) 100059479(PLOD3) 100061030(PLOD2)
MYB: 
102249872(PLOD3) 102257428(PLOD1) 102259135(PLOD2)
MYD: 
102753806(PLOD2) 102755224(PLOD3) 102762645(PLOD1)
PALE: 
102879015(PLOD3) 102881554(PLOD1) 102893099(PLOD2)
MDO: 
100017782(PLOD3) 100017955(PLOD1) 100018666(PLOD2)
SHR: 
100921874(PLOD3) 100928031(PLOD2) 100928370(PLOD1)
OAA: 
100074679(PLOD2) 100076869(PLOD1) 100086224(PLOD3)
GGA: 
419485(PLOD1) 424882(PLOD2)
MGP: 
APLA: 
TGU: 
100217784(PLOD1) 100224084(PLOD2)
FAB: 
101811005(PLOD2) 101816277(PLOD1)
PHI: 
102103019(PLOD2) 102110217(PLOD1)
FPG: 
101910585(PLOD2) 101912951(PLOD1)
FCH: 
102049083(PLOD2) 102058202(PLOD1)
CLV: 
102087276(PLOD2) 102088770(PLOD1)
ASN: 
102368832(PLOD1) 102375469 102376214(PLOD2) 102379166(PLOD3)
AMJ: 
102561107(PLOD3) 102572097(PLOD2) 102572760(PLOD1)
PSS: 
CMY: 
102934230(PLOD1) 102938302(PLOD2)
ACS: 
100558042(plod3) 100558233(plod2) 103282406(plod1)
PBI: 
XLA: 
380138(plod3) 495112(plod1)
XTR: 
100489636(plod2) 734090(plod3) 779793(plod1)
DRE: 
100036767(plod2) 322766(fb72h05) 556077(plod3) 777635(plod1a)
TRU: 
100101241(fglh1) 100101242(fglh3) 100101243(fglh2) 101067748
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
103177516(plod2) 103181397(plod1)
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CELE_F52H3.1(let-268)
CBR: 
CBG13377(Cbr-let-268)
BMY: 
LOA: 
TSP: 
NVE: 
HMG: 
TAD: 
AQU: 
 » show all
Taxonomy
Reference
1  [PMID:6033801]
  Authors
Hausmann E.
  Title
Cofactor requirements for the enzymatic hydroxylation of lysine in a polypeptide precursor of collagen.
  Journal
Biochim. Biophys. Acta. 133 (1967) 591-3.
Reference
2  [PMID:5244754]
  Authors
Rhoads RE, Udenfriend S.
  Title
Decarboxylation of alpha-ketoglutarate coupled to collagen proline hydroxylase.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 60 (1968) 1473-8.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9059-25-0

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