| Entry |
|
|---|
| Name |
procollagen-lysine 5-dioxygenase;
lysine hydroxylase;
lysine,2-oxoglutarate 5-dioxygenase;
protocollagen lysine dioxygenase;
collagen lysine hydroxylase;
lysine-2-oxoglutarate dioxygenase;
lysyl hydroxylase;
lysylprotocollagen dioxygenase;
protocollagen lysyl hydroxylase;
peptidyl-lysine, 2-oxoglutarate: oxygen oxidoreductase;
peptidyllysine, 2-oxoglutarate:oxygen 5-oxidoreductase;
protocollagen lysine hydroxylase;
procollagen-L-lysine,2-oxoglutarate:oxygen oxidoreductase
(5-hydroxylating) |
|---|
| Class |
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or
reduction of oxygen. The oxygen incorporated need not be derived
from O2;
With 2-oxoglutarate as one donor, and incorporation of one atom of
oxygen into each donor
 |
|---|
| Sysname |
L-lysine-[procollagen],2-oxoglutarate:oxygen oxidoreductase
(5-hydroxylating) |
|---|
| Reaction(IUBMB) |
L-lysine-[procollagen] + 2-oxoglutarate + O2 = (2S,5R)-
5-hydroxy-L-lysine-[procollagen] + succinate + CO2 |
|---|
| Reaction(KEGG) |
(other) R03376
 |
|---|
| Substrate |
L-lysine-[procollagen];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007] |
|---|
| Product |
(2S,5R)- 5-hydroxy-L-lysine-[procollagen];
succinate [CPD:C00042];
CO2 [CPD:C00011] |
|---|
| Cofactor |
Iron [CPD:C00023];
Ascorbate [CPD:C00072] |
|---|
| Comment |
Requires Fe2+ and ascorbate. |
|---|
| Pathway |
PATH: ec00310 Lysine degradation |
|---|
| Orthology |
KO: K00473 procollagen-lysine,2-oxoglutarate 5-dioxygenase |
|---|
| Genes |
HSA: 5351(PLOD1) 5352(PLOD2) 8985(PLOD3)
PTR: 457956(PLOD1) 460754(PLOD2) 463618(PLOD3)
MMU: 18822(Plod1) 26432(Plod2) 26433(Plod3)
RNO: 116552(Plod1) 288583(Plod3) 300901(Plod2)
CFA: 479730(PLOD3) 485702(PLOD2) 487440(PLOD1)
BTA: 281409(PLOD1) 514996(PLOD3) 533642(PLOD2)
ECB: 100050902 100059479(PLOD3) 100061030
MDO: 100017782 100017955 100018666
OAA: 100074679 100086224
GGA: 419485(PLOD1) 424882(PLOD2)
TGU: 100217784 100224084
XLA: 380138(plod) 495112
XTR: 734090 779793(plod1)
DRE: 100036767(plod2) 556077(plod3) 777635(plod1a)
BFO: BRAFLDRAFT_280606
CIN: 100178986
SPU: 576306
DME: Dmel_CG6199
DPO: Dpse_GA19434
DAN: Dana_GF24561
DER: Dere_GG13929
DSE: Dsec_GM24765
DSI: Dsim_GD12814
DYA: Dyak_GE20228
DGR: Dgri_GH16659
DMO: Dmoj_GI11618
AGA: AgaP_AGAP001507
AAG: AaeL_AAEL008099
CQU: CpipJ_CPIJ011582
NVI: 100117467
TCA: 662642
API: 100162555
ISC: IscW_ISCW007221
CEL: F52H3.1(let-268)
CBR: CBG13377
BMY: Bm1_42125
NVE: NEMVE_v1g234891
HMG: 100212717
TAD: TRIADDRAFT_50405
MBR: MONBRDRAFT_16641 MONBRDRAFT_28874
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:6033801]
Hausmann E.
Cofactor requirements for the enzymatic hydroxylation of lysine in a
polypeptide precursor of collagen.
Biochim. Biophys. Acta. 133 (1967) 591-3.
Gallus gallus [GN:gga] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:5244754]
Rhoads RE, Udenfriend S.
Decarboxylation of alpha-ketoglutarate coupled to collagen proline
hydroxylase.
Proc. Natl. Acad. Sci. U. S. A. 60 (1968) 1473-8.
Rattus norvegicus [GN:rno] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.14.11.4
IUBMB Enzyme Nomenclature: 1.14.11.4
ExPASy - ENZYME nomenclature database: 1.14.11.4
BRENDA, the Enzyme Database: 1.14.11.4
CAS: 9059-25-0 |
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