| Entry |
|
|---|
| Name |
trimethyllysine dioxygenase;
trimethyllysine alpha-ketoglutarate dioxygenase;
TML-alpha-ketoglutarate dioxygenase;
TML hydroxylase;
6-N,6-N,6-N-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase
(3-hydroxylating) |
|---|
| Class |
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or
reduction of oxygen. The oxygen incorporated need not be derived
from O2;
With 2-oxoglutarate as one donor, and incorporation of one atom of
oxygen into each donor
 |
|---|
| Sysname |
N6,N6,N6-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase
(3-hydroxylating) |
|---|
| Reaction(IUBMB) |
N6,N6,N6-trimethyl-L-lysine + 2-oxoglutarate + O2 =
3-hydroxy-N6,N6,N6-trimethyl-L-lysine + succinate + CO2 [RN:R03451] |
|---|
| Reaction(KEGG) |
R03451
 |
|---|
| Substrate |
N6,N6,N6-trimethyl-L-lysine [CPD:C03793];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007] |
|---|
| Product |
3-hydroxy-N6,N6,N6-trimethyl-L-lysine [CPD:C01259];
succinate [CPD:C00042];
CO2 [CPD:C00011] |
|---|
| Cofactor |
Iron [CPD:C00023];
Ascorbate [CPD:C00072];
Fe2+ [CPD:C14818] |
|---|
| Comment |
Requires Fe2+ and ascorbate. |
|---|
| Pathway |
PATH: ec00310 Lysine degradation |
|---|
| Orthology |
KO: K00474 trimethyllysine dioxygenase |
|---|
| Genes |
HSA: 55217(TMLHE)
PTR: 465953(TMLHE)
MCC: 703711(TMLHE)
MMU: 192289(Tmlhe)
RNO: 170898(Tmlhe)
CFA: 481090(TMLHE)
BTA: 535630(TMLHE)
ECB: 100062170
MDO: 100024134
OAA: 100084207
GGA: 422296(TMLHE)
TGU: 100230324
DRE: 555271
NVE: NEMVE_v1g122521
AGO: AGOS_AEL035W
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:627563]
Hulse JD, Ellis SR, Henderson LM.
Carnitine biosynthesis. beta-Hydroxylation of trimethyllysine by an
alpha-ketoglutarate-dependent mitochondrial dioxygenase.
J. Biol. Chem. 253 (1978) 1654-9.
Rattus norvegicus [GN:rno] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.14.11.8
IUBMB Enzyme Nomenclature: 1.14.11.8
ExPASy - ENZYME nomenclature database: 1.14.11.8
BRENDA, the Enzyme Database: 1.14.11.8
CAS: 74622-49-4 |
|---|
