| Entry |
|
|---|
| Name |
flavanone 3-dioxygenase;
naringenin 3-hydroxylase;
flavanone 3-hydroxylase;
flavanone 3beta-hydroxylase;
flavanone synthase I;
(2S)-flavanone 3-hydroxylase;
naringenin,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) |
|---|
| Class |
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or
reduction of oxygen. The oxygen incorporated need not be derived
from O2;
With 2-oxoglutarate as one donor, and incorporation of one atom of
oxygen into each donor
 |
|---|
| Sysname |
flavanone,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) |
|---|
| Reaction(IUBMB) |
a flavanone + 2-oxoglutarate + O2 = a dihydroflavonol + succinate +
CO2 [RN:R07329] |
|---|
| Reaction(KEGG) |
R07329 > R02444 R03640 R05039 R07993 R07996 R07997
 |
|---|
| Substrate |
flavanone [CPD:C00766];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007] |
|---|
| Product |
dihydroflavonol [CPD:C15570];
succinate [CPD:C00042];
CO2 [CPD:C00011] |
|---|
| Cofactor |
Iron [CPD:C00023];
Ascorbate [CPD:C00072] |
|---|
| Comment |
Requires Fe2+ and ascorbate. |
|---|
| Pathway |
PATH: ec00941 Flavonoid biosynthesis
PATH: ec01061 Biosynthesis of phenylpropanoids
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00475 naringenin 3-dioxygenase |
|---|
| Genes |
ATH: AT3G51240(F3H)
OSA: 4337296(Os04g0662600)
PIC: PICST_32280(NGD3)
 |
|---|
Reference
Authors
Title
Journal
|
1
Forkmann, G., Heller, W. and Grisebach, H.
Anthocyanin biosynthesis in flowers of Matthiola incana flavanone 3-
and flavonoid 3'-hydroxylases.
Z. Naturforsch. C: Biosci. 35 (1980) 691-695. |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:15013767]
Wellmann F, Matern U, Lukacin R.
Significance of C-terminal sequence elements for Petunia flavanone
3beta-hydroxylase activity.
FEBS. Lett. 561 (2004) 149-54.
Citrus unshiu, Petunia hybrida |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.14.11.9
IUBMB Enzyme Nomenclature: 1.14.11.9
ExPASy - ENZYME nomenclature database: 1.14.11.9
BRENDA, the Enzyme Database: 1.14.11.9
CAS: 75991-43-4 |
|---|
