| Entry |
|
|---|
| Name |
2-chlorobenzoate 1,2-dioxygenase;
2-halobenzoate 1,2-dioxygenase |
|---|
| Class |
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or
reduction of oxygen. The oxygen incorporated need not be derived
from O2;
With NADH or NADPH as one donor, and incorporation of two atoms of
oxygen into the other donor
 |
|---|
| Sysname |
2-chlorobenzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating,
dechlorinating, decarboxylating) |
|---|
| Reaction(IUBMB) |
2-chlorobenzoate + NADH + H+ + O2 = catechol + chloride + NAD+ + CO2
[RN:R01033] |
|---|
| Reaction(KEGG) |
R01033
 |
|---|
| Substrate |
2-chlorobenzoate [CPD:C02357];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007] |
|---|
| Product |
catechol [CPD:C00090];
chloride [CPD:C00698];
NAD+ [CPD:C00003];
CO2 [CPD:C00011] |
|---|
| Cofactor |
Iron [CPD:C00023] |
|---|
| Comment |
Requires Fe2+. |
|---|
| Pathway |
PATH: ec00632 Benzoate degradation via CoA ligation |
|---|
| Orthology |
KO: K08686 2-chlorobenzoate 1,2-dioxygenase |
|---|
| Genes |
PFO: Pfl01_2322
PCR: Pcryo_1266
RPI: Rpic_1365
REU: Reut_B4404
BVI: Bcep1808_5826
BUR: Bcep18194_C7047 Bcep18194_C7073
BCN: Bcen_1305
BCH: Bcen2424_6525
BCJ: BCAS0495(benB)
BAM: Bamb_6583
BMJ: BMULJ_05286(benB)
BXE: Bxe_A1107(ohbB) Bxe_A1108(ohbA)
BPY: Bphyt_1592
PNA: Pnap_2111
PDE: Pden_1178
NAR: Saro_0539
MSM: MSMEG_1907
MGI: Mflv_1354
MMC: Mmcs_1372
MKM: Mkms_1390
MJL: Mjls_1406
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:2610934]
Fetzner S, Muller R, Lingens F.
Degradation of 2-chlorobenzoate by Pseudomonas cepacia 2CBS.
Biol. Chem. Hoppe. Seyler. 370 (1989) 1173-82.
Pseudomonas cepacia |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.14.12.13
IUBMB Enzyme Nomenclature: 1.14.12.13
ExPASy - ENZYME nomenclature database: 1.14.12.13
UM-BBD (Biocatalysis/Biodegradation Database): 1.14.12.13
BRENDA, the Enzyme Database: 1.14.12.13
CAS: 125268-83-9 |
|---|
