| Entry |
|
|---|
| Name |
3-hydroxy-2-methylpyridinecarboxylate dioxygenase;
methylhydroxypyridinecarboxylate oxidase;
2-methyl-3-hydroxypyridine 5-carboxylic acid dioxygenase;
methylhydroxypyridine carboxylate dioxygenase;
3-hydroxy-3-methylpyridinecarboxylate dioxygenase [incorrect] |
|---|
| Class |
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or
reduction of oxygen. The oxygen incorporated need not be derived
from O2;
With NADH or NADPH as one donor, and incorporation of two atoms of
oxygen into the other donor
 |
|---|
| Sysname |
3-hydroxy-2-methylpyridine-5-carboxylate,NAD(P)H:oxygen
oxidoreductase (decyclizing) |
|---|
| Reaction(IUBMB) |
3-hydroxy-2-methylpyridine-5-carboxylate + NAD(P)H + H+ + O2 =
2-(acetamidomethylene)succinate + NAD(P)+ [RN:R03385 R03386] |
|---|
| Reaction(KEGG) |
R03385 R03386
 |
|---|
| Substrate |
3-hydroxy-2-methylpyridine-5-carboxylate [CPD:C01270];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007] |
|---|
| Product |
2-(acetamidomethylene)succinate [CPD:C01215];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006] |
|---|
| Cofactor |
FAD [CPD:C00016] |
|---|
| Comment |
A flavoprotein (FAD). |
|---|
| Pathway |
PATH: ec00750 Vitamin B6 metabolism |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:4306031]
Sparrow LG, Ho PP, Sundaram TK, Zach D, Nyns EJ, Snell EE.
The bacterial oxidation of vitamin B6. VII. Purification,
properties, and mechanism of action of an oxygenase which cleaves
the 3-hydroxypyridine ring.
J. Biol. Chem. 244 (1969) 2590-600.
Pseudomonas sp. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.14.12.4
IUBMB Enzyme Nomenclature: 1.14.12.4
ExPASy - ENZYME nomenclature database: 1.14.12.4
UM-BBD (Biocatalysis/Biodegradation Database): 1.14.12.4
BRENDA, the Enzyme Database: 1.14.12.4
CAS: 37256-69-2 |
|---|
