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Entry
EC 1.14.13.114              Enzyme                                 

Name
6-hydroxynicotinate 3-monooxygenase;
NicC;
6HNA monooxygenase;
HNA-3-monooxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
6-hydroxynicotinate,NADH:oxygen oxidoreductase (3-hydroxylating, decarboxylating)
Reaction(IUBMB)
6-hydroxynicotinate + NADH + H+ + O2 = 2,5-dihydroxypyridine + NAD+ + H2O + CO2 [RN:R08764]
Reaction(KEGG)
Substrate
6-hydroxynicotinate [CPD:C01020];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
2,5-dihydroxypyridine [CPD:C01059];
NAD+ [CPD:C00003];
H2O [CPD:C00001];
CO2 [CPD:C00011]
Comment
A flavoprotein (FAD) [1]. The reaction is involved in the aerobic catabolism of nicotinic acid.
History
EC 1.14.13.114 created 2010
Pathway
Nicotinate and nicotinamide metabolism
Microbial metabolism in diverse environments
Orthology
K14974  
6-hydroxynicotinate 3-monooxygenase
Genes
SPE: 
SRR: 
SRL: 
SRY: 
SRS: 
SRA: 
SMW: 
SLQ: 
SERF: 
PAO: 
PPU: 
PP_3944(nahG)
PPF: 
PPG: 
PPW: 
PPB: 
PPI: 
PPX: 
PPUT: 
PPUN: 
PFS: 
PSK: 
ADI: 
RPJ: 
REU: 
REH: 
H16_A0922(h16_A0922)
CNC: 
CTI: 
BCN: 
BCH: 
BCM: 
BCJ: 
BCEN: 
BMU: 
BMJ: 
BMK: 
BCED: 
BGL: 
BGD: 
BUO: 
BPE: 
BPC: 
BPER: 
BPA: 
BBR: 
BBM: 
BBH: 
BPT: 
BAV: 
AXO: 
AXN: 
AXS: 
AMIM: 
AAV: 
AAA: 
DAC: 
DEL: 
CTES: 
HSE: 
RLG: 
RTR: 
BJU: 
HMC: 
GXL: 
APT: 
APW: 
APF: 
APU: 
APG: 
APQ: 
APX: 
APZ: 
APK: 
ALI: 
 » show all
Taxonomy
Reference
1  [PMID:10091591]
  Authors
Nakano H, Wieser M, Hurh B, Kawai T, Yoshida T, Yamane T, Nagasawa T.
  Title
Purification, characterization and gene cloning of 6-hydroxynicotinate 3-monooxygenase from Pseudomonas fluorescens TN5.
  Journal
Eur. J. Biochem. 260 (1999) 120-6.
  Sequence
[up:P86491]
Reference
2  [PMID:18678916]
  Authors
Jimenez JI, Canales A, Jimenez-Barbero J, Ginalski K, Rychlewski L, Garcia JL, Diaz E
  Title
Deciphering the genetic determinants for aerobic nicotinic acid degradation: the  nic cluster from Pseudomonas putida KT2440.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 11329-34.
  Sequence
[ppu:PP_3944]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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