KEGG   ENZYME: 1.14.13.13Help
Entry
EC 1.14.13.13               Enzyme                                 

Name
calcidiol 1-monooxygenase;
25-hydroxycholecalciferol 1-hydroxylase;
25-hydroxycholecalciferol 1-monooxygenase;
1-hydroxylase-25-hydroxyvitamin D3;
25-hydroxy D3-1alpha-hydroxylase;
25-hydroxycholecalciferol 1alpha-hydroxylase;
25-hydroxyvitamin D3 1alpha-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating)
Reaction(IUBMB)
calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O [RN:R03610]
Reaction(KEGG)
Substrate
calcidiol [CPD:C01561];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
calcitriol [CPD:C01673];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
History
EC 1.14.13.13 created 1976
Pathway
Steroid biosynthesis
Metabolic pathways
Orthology
K07438  
25-hydroxyvitamin D3 1alpha-hydroxylase
Genes
HSA: 
1594(CYP27B1)
PTR: 
452027(CYP27B1)
PPS: 
GGO: 
PON: 
NLE: 
MCC: 
715747(CYP27B1)
MCF: 
CJC: 
100388588(CYP27B1)
MMU: 
13115(Cyp27b1)
RNO: 
114700(Cyp27b1)
CGE: 
NGI: 
HGL: 
OCU: 
TUP: 
CFA: 
481133(CYP27B1)
AML: 
UMR: 
FCA: 
100750221(CYP27B1)
PTG: 
BTA: 
539630(CYP27B1)
BOM: 
PHD: 
CHX: 
OAS: 
SSC: 
397055(CYP27B1)
CFR: 
BACU: 
LVE: 
ECB: 
100034100(CYP27B1)
MYB: 
MYD: 
PALE: 
MDO: 
SHR: 
FAB: 
PHI: 
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
PBI: 
XTR: 
448754(cyp27b1)
DRE: 
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
 » show all
Taxonomy
Reference
1  [PMID:4404596]
  Authors
Gray RW, Omdahl JL, Ghazarian JG, DeLuca HF.
  Title
25-Hydroxycholecalciferol-1-hydroxylase. Subcellular location and properties.
  Journal
J. Biol. Chem. 247 (1972) 7528-32.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9081-36-1

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