KEGG   ENZYME: 1.14.13.13Help
Entry
EC 1.14.13.13               Enzyme                                 
Name
calcidiol 1-monooxygenase;
25-hydroxycholecalciferol 1-hydroxylase;
25-hydroxycholecalciferol 1-monooxygenase;
1-hydroxylase-25-hydroxyvitamin D3;
25-hydroxy D3-1alpha-hydroxylase;
25-hydroxycholecalciferol 1alpha-hydroxylase;
25-hydroxyvitamin D3 1alpha-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating)
Reaction(IUBMB)
calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O [RN:R03610]
Reaction(KEGG)
Substrate
calcidiol [CPD:C01561];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
calcitriol [CPD:C01673];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Pathway
Steroid biosynthesis
Metabolic pathways
Orthology
K07438  
cytochrome P450, family 27, subfamily B (25-hydroxyvitamin D3 1alpha-hydroxylase)
Genes
HSA: 
1594(CYP27B1)
PTR: 
452027(CYP27B1)
PPS: 
GGO: 
PON: 
MCC: 
715747(CYP27B1)
MMU: 
13115(Cyp27b1)
RNO: 
114700(Cyp27b1)
CFA: 
481133(CYP27B1)
AML: 
FCA: 
100750221(CYP27B1)
BTA: 
539630(CYP27B1)
SSC: 
397055(CYP27B1)
ECB: 
100034100(CYP27B1)
MDO: 
100031497
SHR: 
100913970
ACS: 
100559713
XTR: 
448754(cyp27b1)
DRE: 
793309
TRU: 
101062641
OLA: 
101172325
 » show all
Taxonomy
Reference
1  [PMID:4404596]
  Authors
Gray RW, Omdahl JL, Ghazarian JG, DeLuca HF.
  Title
25-Hydroxycholecalciferol-1-hydroxylase. Subcellular location and properties.
  Journal
J. Biol. Chem. 247 (1972) 7528-32.
  Organism
Gallus gallus [GN:gga]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9081-36-1
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