KEGG   ENZYME: 1.14.13.19Help
Entry
EC 1.14.13.19               Enzyme                                 

Name
taxifolin 8-monooxygenase;
taxifolin hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
taxifolin,NAD(P)H:oxygen oxidoreductase (8-hydroxylating)
Reaction(IUBMB)
taxifolin + NAD(P)H + H+ + O2 = 2,3-dihydrogossypetin + NAD(P)+ + H2O [RN:R03637 R03638]
Reaction(KEGG)
Substrate
taxifolin [CPD:C01617];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
2,3-dihydrogossypetin [CPD:C03052];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
A flavoprotein, converting a flavanol into a flavanone. Also acts on fustin, but not on catechin, quercetin or mollisacidin.
History
EC 1.14.13.19 created 1976
Reference
1  [PMID:4146277]
  Authors
Jeffrey AM, Knight M, Evans WC.
  Title
The bacterial degradation of flavonoids. Hydroxylation of the A-ring of taxifolin by a soil pseudomonad.
  Journal
Biochem. J. 130 (1972) 373-81.
  Organism
Pseudomonas sp.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
39307-19-2

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